TY  - JOUR
A1  - Rackwitz, Jenny
A1  - Kopyra, Janina
A1  - Dabkowska, Iwona
A1  - Ebel, Kenny
A1  - Rankovic, MiloS Lj.
A1  - Milosavljevic, Aleksandar R.
A1  - Bald, Ilko
T1  - Sensitizing DNA Towards Low-Energy Electrons with 2-Fluoroadenine
JF  - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition
N2  - 2-Fluoroadenine ((2F)A) is a therapeutic agent, which is suggested for application in cancer radiotherapy. The molecular mechanism of DNA radiation damage can be ascribed to a significant extent to the action of low-energy (<20 eV) electrons (LEEs), which damage DNA by dissociative electron attachment. LEE induced reactions in (2F)A are characterized both isolated in the gas phase and in the condensed phase when it is incorporated into DNA. Information about negative ion resonances and anion-mediated fragmentation reactions is combined with an absolute quantification of DNA strand breaks in (2F)A-containing oligonucleotides upon irradiation with LEEs. The incorporation of (2F)A into DNA results in an enhanced strand breakage. The strand-break cross sections are clearly energy dependent, whereas the strand-break enhancements by (2F)A at 5.5, 10, and 15 eV are very similar. Thus, (2F)A can be considered an effective radiosensitizer operative at a wide range of electron energies.
KW  - ab initio calculations
KW  - dissociative electron attachment
KW  - DNA origami
KW  - DNA radiation damage
KW  - fludarabine
Y1  - 2016
U6  - https://doi.org/10.1002/anie.201603464
SN  - 1433-7851
SN  - 1521-3773
VL  - 55
SP  - 10248
EP  - 10252
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - THES
A1  - Rackwitz, Jenny
T1  - A novel approach to study low-energy electron-induced damage to DNA oligonucleotides
BT  - Influence of DNA sequence, topology and nucleobase modification
Y1  - 2016
ER  -