TY  - JOUR
A1  - Park, H.
A1  - Walta, S.
A1  - Rosencrantz, Ruben R.
A1  - Koerner, A.
A1  - Schulte, Christoph
A1  - Elling, L.
A1  - Richtering, Walter
A1  - Böker, Alexander
T1  - Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding
JF  - Polymer Chemistry
N2  - We introduce a novel double-hydrophilic hydroxyethylmethacrylate (HEMA) based diblock glycopolymer which self-assembles into homogeneous spherical micellar structures in water. The micellar structure renders surface-oriented N-acetylglucocosamine (GlcNAc) sugar moieties for strong multivalent glycan-mediated lectin binding. Structural analysis and lectin binding is performed by microscopy methods, dynamic light scattering (DLS) and two-focus fluorescence correlation spectroscopy (2fFCS), revealing a novel micellar type of multivalent sugar binding scaffold with high potential for biomedical applications.
Y1  - 2016
U6  - https://doi.org/10.1039/c5py00797f
SN  - 1759-9954
SN  - 1759-9962
VL  - 7
SP  - 878
EP  - 886
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  -