TY  - JOUR
A1  - Cherstvy, Andrey G.
A1  - Petrov, Eugene P.
T1  - Modeling DNA condensation on freestanding cationic lipid membranes
JF  - Physical chemistry, chemical physics : a journal of European Chemical Societies
N2  - Motivated by recent experimental observations of a rapid spontaneous DNA coil-globule transition on freestanding cationic lipid bilayers, we propose simple theoretical models for DNA condensation on cationic lipid membranes. First, for a single DNA rod, we examine the conditions of full wrapping of a cylindrical DNA-like semi-flexible polyelectrolyte by an oppositely charged membrane. Then, for two parallel DNA rods, we self-consistently analyze the shape and the extent of the membrane enveloping them, focusing on membrane elastic deformations and the membrane-DNA embracing angle, which enables us to compute the membrane-mediated DNA-DNA interactions. We examine the effects of the membrane composition and its charge density, which are the experimentally tunable parameters. We show that membrane-driven rod-rod attraction is more pronounced for higher charge densities and for smaller surface tensions of the membrane. Thus, we demonstrate that for a long DNA chain adhered to a cationic lipid membrane, such membrane-induced DNA-DNA attraction can trigger compaction of DNA.
Y1  - 2014
U6  - https://doi.org/10.1039/c3cp53433b
SN  - 1463-9076
SN  - 1463-9084
VL  - 16
IS  - 5
SP  - 2020
EP  - 2037
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  -