TY  - JOUR
A1  - Mehnert, Jan
A1  - Brunetti, Maddalena
A1  - Steinbrink, Jens
A1  - Niedeggen, Michael
A1  - Dohle, Christian
T1  - Effect of a mirror-like illusion on activation in the precuneus assessed with functional near-infrared spectroscopy
JF  - Journal of biomedical optics
N2  - Mirror therapy is a therapy to treat patients with pain syndromes or hemiparesis after stroke. However, the underlying neurophysiologic mechanisms are not clearly understood. In order to determine the effect of a mirror-like illusion (MIR) on brain activity using functional near-infrared spectroscopy, 20 healthy right-handed subjects were examined. A MIR was induced by a digital horizontal inversion of the subjects' filmed hand. Optodes were placed on the primary motor cortex (M1) and the occipito-parietal cortex (precuneus, PC). Regions of interest (ROI) were defined a priori based on previous results of similar studies and confirmed by the analysis of effect sizes. Analysis of variance of the ROI signal revealed a dissociated pattern: at the PC, the MIR caused a significant inversion of a hemispheric lateralization opposite to the perceived hand, independent of the moving hand. In contrast, activity in M1 showed lateralization opposite to the moving hand, but revealed no mirror effect. These findings extend our understanding on interhemispheric rivalry and indicate that a MIR is integrated into visuomotor coordination similar to normal view, irrespective of the hand that is actually performing the task. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
KW  - functional near-infrared spectroscopy
KW  - optical imaging
KW  - mirror illusion
KW  - mirror therapy
KW  - precuneus
Y1  - 2013
U6  - https://doi.org/10.1117/1.JBO.18.6.066001
SN  - 1083-3668
VL  - 18
IS  - 6
PB  - SPIE
CY  - Bellingham
ER  - 
TY  - JOUR
A1  - Wang, Jing
A1  - Fritzsch, Claire
A1  - Bernarding, Johannes
A1  - Holtze, Susanne
A1  - Mauritz, Karl-Heinz
A1  - Brunetti, Maddalena
A1  - Dohle, Christian
T1  - A comparison of neural mechanisms in mirror therapy and movement observation therapy
JF  - Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine
N2  - Objective: To compare lateralized cerebral activations elicited during self-initiated movement mirroring and observation of movements.
 Subjects: A total of 15 right-handed healthy subjects, age range 22-56 years.
 Methods: Functional imaging study comparing movement mirroring with movement observation, in both hands, in an otherwise identical setting. Imaging data were analysed using statistical parametric mapping software, with significance threshold set at p<0.01 (false discovery rate) and a minimum cluster size of 20 voxels.
 Results: Movement mirroring induced additional activation in primary and higher-order visual areas strictly contralateral to the limb seen by the subject. There was no significant difference of brain activity when comparing movement observation of somebody else's right hand with left hand.
 Conclusion: Lateralized cerebral activations are elicited by inversion of visual feedback (movement mirroring), but not by movement observation.
KW  - fMRI
KW  - mirror
KW  - movement
KW  - observation
KW  - precuneus
Y1  - 2013
U6  - https://doi.org/10.2340/16501977-1127
SN  - 1650-1977
VL  - 45
IS  - 4
SP  - 410
EP  - 413
PB  - Foundation for Rehabilitation Information
CY  - Uppsala
ER  -