TY - JOUR A1 - Haßler, Gerda T1 - Le Trésor des vocabulaires francophones (TVF) : objectif descriptif - réponse normatives? Y1 - 2008 SN - 978-3-631-56596-4 ER - TY - JOUR A1 - Siegmüller, Julia A1 - Fröhling, Astrid A1 - Herrmann, Heike A1 - Gies, Jeannine T1 - Zur Verbesserung des Sprachmodells von Erzieherinnen als Methode zur allgemeinen integrativen Sprachförderung in Kitas - Inputspezifizierung im Kindergarten Y1 - 2008 ER - TY - JOUR A1 - Wick, Ditmar A1 - Möller, Sebastian A1 - Krüger, Tom A1 - Kittel, René T1 - Analyse und Optimierung angriffsspezifischer Technikelemente : individuelle Bewegungsprofile von Spitzenjudoka Y1 - 2010 UR - http://www.bisp.de/nn_113306/DE/Produkte/Publikationen/BISp-Jahrbuch.html ER - TY - JOUR A1 - Gärtner, Ursula T1 - Vom Rausch des praeco immodicus zur Literaturkritik : Heinsius und seine Dissertatio zu Nonnos Y1 - 2008 SN - 978-3-8233-6339-2 ER - TY - JOUR A1 - Creuzberger, Stefan T1 - Das BMG in der frühen Bonner Republik Y1 - 2009 UR - http://www1.bpb.de/publikationen/11SG4B,0,Das_BMG_in_der_fr%FChen_Bonner_Republik.html ER - TY - JOUR A1 - Janz, Norbert A1 - Beckemper, Katharina T1 - Rien ne va plus : zur Strafbarkeit wegen des Anbietens privater Sportwetten nach der Sportwettenentscheidung des BVerfG v. 28.3.2006 Y1 - 2008 ER - TY - JOUR A1 - Peyer, Mathias A1 - Balderjahn, Ingo T1 - Zahlungsbereitschaft für sozialverträgliche Produkte N2 - Studien im Bereich des fairen Handels schätzen oftmals hohe Zahlungsbereitschaften der Kon-sumenten. Die geringen Marktanteile für fair gehandelte Produkte liefern jedoch ein anderes Bild und lassen auf eine hohe soziale Wünschbarkeit in den Antworten schließen. Ziel dieser Studie war es mittels Discrete-Choice-Analyse den Probanden in einer realitätsnahen Kaufsitua-tion sozialverträgliche Produkte anzubieten. Im Rahmen der Diskreten Entscheidungsanalyse wurden Kaufwahrscheinlichkeiten und Marktanteile für die einzelnen Produkte geschätzt. Ins-besondere in Kombination mit einem Markenprodukt lassen die ermittelten Mehrpreisbereit-schaften auf nicht unerhebliche Marktchancen für gesiegelte Produkte schließen. Die Ergebnis-se zeigen auch, dass mehr Informationen und höheres Vertrauen der Konsumenten über Fair Trade zu einer gesteigerten Preisbereitschaft führen. Als Resultat der Zertifizierung mit Fair Trade Siegeln wurden nicht zu unterschätzende Wettbewerbsvorteile für Produzenten von Kon-sumgütern festgestellt. Y1 - 2008 ER - TY - JOUR A1 - Haßler, Gerda T1 - Der unendliche Gebrauch endlicher Mittel : Erklärungen sprachlicher Kreativität des Menschen Y1 - 2008 SN - 978-3-534-17505-5 ER - TY - JOUR A1 - Sellrie, Frank A1 - Warsinke, Axel A1 - Micheel, Burkhard T1 - Homogeneous indirect fluorescence quenching immunoassay for the determination of low molecular weight substances JF - Analytical & bioanalytical chemistry N2 - This paper describes the principle of a homogeneous indirect fluorescence quenching immunoassay that uses monoclonal antibodies. It is a carrier-free assay system that is performed completely in solution. The assay system was established for the determination of a low molecular weight substance (hapten), the herbicide diuron, used as a model analyte. A fluorescein-monuron conjugate together with a fluorescence-quenching monoclonal anti-fluorescein antibody and an anti-analyte antibody (here an anti-diuron/monuron monoclonal antibody) were used as central components of the assay. The fluorescein-monuron conjugate can be bound either by the anti-fluorescein monoclonal antibody or by the anti-diuron/ monuron monoclonal antibody. Due to steric hindrance, binding of both antibodies to the conjugate was not possible at the same time. By selecting the antibody concentrations appropriately, a dynamic equilibrium can be established that permits the preferential binding of the anti-diuron/monuron antibody to the conjugate, which allows the fluorescein in the conjugate to fluoresce. This equilibrium can be easily altered by adding free analyte (diuron), which competes with the conjugate to bind to the anti-diuron/monuron antibody. A reduction of anti-diuron/monuron antibody binding to the conjugate results in an increase in the binding of the anti-fluorescein antibody, which leads to a decrease in the fluorescence of the conjugate. The fluorescence is therefore a direct indicator of the state of equilibrium of the system and thus also the presence of free unconjugated analyte. The determination of an analyte based on this test principle does not require any washing steps. After the test components are mixed, the dynamic equilibrium is rapidly reached and the results can be obtained in less than 5 min by measuring the fluorescence of the fluorescein. We used this test principle for the determination of diuron, which was demonstrated for concentrations of approximately 5 nM. Y1 - 2008 UR - http://www.springerlink.com/content/n7227875454216v7/ VL - 386 IS - 2 SP - 206 EP - 210 ER - TY - JOUR A1 - Schlag, Peter M. A1 - Osterziel, Karl Joseph A1 - Özcelik, Cemil A1 - Scherneck, Siegfried A1 - Wenzel, Katrin A1 - Daskalow, Katjana A1 - Herse, Florian A1 - Seitz, Susanne A1 - Zacharias, Ute A1 - Schenk, Jörg A. A1 - Schulz, Herbert A1 - Hübner, Norbert A1 - Micheel, Burkhard T1 - The protein phosphatase 1 inhibitor KEPI is down regulated in breast cancer cell lines and tissues and involved in the regulation of the tumour suppressor EGR1 via the MEK-ERK pathway N2 - KEPI is a protein kinase C-potentiated inhibitory protein for type 1 Ser/Thr protein phosphatases. We found no or reduced expression of KEPI in breast cancer cell lines, breast tumors and metastases in comparison to normal breast cell lines and tissues, respectively. KEPI protein expression and ubiquitous localization was detected with a newly generated antibody. Ectopic KEPI expression in MCF7 breast cancer cells induced differential expression of 95 genes, including the up-regulation of the tumor suppressors EGR1 (early growth response 1) and PTEN (phosphatase and tensin homolog), which is regulated by EGR1. We further show that the up-regulation of EGR1 in MCF7/KEPI cells is mediated by MEK-ERK signaling. The inhibition of this pathway by the MEK inhibitor UO126 led to a strong decrease in EGR1 expression in MCF7/KEPI cells. These results reveal a novel role for KEPI in the regulation of the tumor suppressor gene EGR1 via activation of the MEK-ERK MAPK pathway. Y1 - 2008 UR - http://www.atypon-link.com/doi/abs/10.1515/BC.2007.062 ER -