TY  - INPR
A1  - Hocher, Berthold
A1  - Reichetzeder, Christoph
T1  - Vitamin D and cardiovascular risk in postmenopausal women how to translate preclinical evidence into benefit for patients
T2  - Kidney international : official journal of the International Society of Nephrology
N2  - Preclinical work indicates that calcitriol restores vascular function by normalizing the endothelial expression of cyclooxygenase-2 and thromboxane-prostanoid receptors in conditions of estrogen deficiency and thus prevents the thromboxane-prostanoid receptor activation-induced inhibition of nitric oxide synthase. Since endothelial dysfunction is a key factor in the pathogenesis of cardiovascular diseases, this finding may have an important translational impact. It provides a clear rationale to use endothelial function in clinical trials aiming to find the optimal dose of vitamin D for the prevention of cardiovascular events in postmenopausal women.
Y1  - 2013
U6  - https://doi.org/10.1038/ki.2013.139
SN  - 0085-2538
VL  - 84
IS  - 1
SP  - 9
EP  - 11
PB  - Nature Publ. Group
CY  - New York
ER  -