TY - CHAP A1 - Démaris, Alise A1 - Grišić, Ana-Marija A1 - Huisinga, Wilhelm A1 - Walter, Reinisch A1 - Kloft, Charlotte T1 - Evaluation of dosing strategies of anti-TNF alpha monoclonal antibodies using pharmacokinetic modelling and simulation T2 - Journal of Crohn's and Colitis N2 - Background: Anti-TNFα monoclonal antibodies (mAbs) are a well-established treatment for patients with Crohn’s disease (CD). However, subtherapeutic concentrations of mAbs have been related to a loss of response during the first year of therapy1. Therefore, an appropriate dosing strategy is crucial to prevent the underexposure of mAbs for those patients. The aim of our study was to assess the impact of different dosing strategies (fixed dose or body size descriptor adapted) on drug exposure and the target concentration attainment for two different anti-TNFα mAbs: infliximab (IFX, body weight (BW)-based dosing) and certolizumab pegol (CZP, fixed dosing). For this purpose, a comprehensive pharmacokinetic (PK) simulation study was performed. Methods: A virtual population of 1000 clinically representative CD patients was generated based on the distribution of CD patient characteristics from an in-house clinical database (n = 116). Seven dosing regimens were investigated: fixed dose and per BW, lean BW (LBW), body surface area, height, body mass index and fat-free mass. The individual body size-adjusted doses were calculated from patient generated body size descriptor values. Then, using published PK models for IFX and CZP in CD patients2,3, for each patient, 1000 concentration–time profiles were simulated to consider the typical profile of a specific patient as well as the range of possible individual profiles due to unexplained PK variability across patients. For each dosing strategy, the variability in maximum and minimum mAb concentrations (Cmax and Cmin, respectively), area under the concentration-time curve (AUC) and the per cent of patients reaching target concentration were assessed during maintenance therapy. Results: For IFX and CZP, Cmin showed the highest variability between patients (CV ≈110% and CV ≈80%, respectively) with a similar extent across all dosing strategies. For IFX, the per cent of patients reaching the target (Cmin = 5 µg/ml) was similar across all dosing strategies (~15%). For CZP, the per cent of patients reaching the target average concentration of 17 µg/ml ranged substantially (52–71%), being the highest for LBW-adjusted dosing. Conclusion: By using a PK simulation approach, different dosing regimen of IFX and CZP revealed the highest variability for Cmin, the most commonly used PK parameter guiding treatment decisions, independent upon dosing regimen. Our results demonstrate similar target attainment with fixed dosing of IFX compared with currently recommended BW-based dosing. For CZP, the current fixed dosing strategy leads to comparable percentage of patients reaching target as the best performing body size-adjusted dosing (66% vs. 71%, respectively). KW - linical databases KW - crohn's disease KW - regimen KW - monoclonal antibodies KW - body surface area KW - infliximab KW - fat-free mass KW - certolizumab pegol KW - body mass index procedure Y1 - 2020 U6 - https://doi.org/10.1093/ecco-jcc/jjz203.201 SN - 1873-9946 SN - 1876-4479 VL - 14 IS - Supp. 1 SP - S171 EP - S172 PB - Oxford Univ. Press CY - Oxford ER - TY - CHAP ED - Radeva-Bork, Teodora ED - Kosta, Peter T1 - Current developments in Slavic linguistics - twenty years after BT - based on selected papers from FDSL 11 T2 - Potsdam linguistic investigations N2 - The book offers a comprehensive overview of current research in Slavic linguistics from a theoretical and experimental perspective and from a variety of languages. The selected papers from the 11th European Conference on Formal Description of Slavic Languages (FDSL 11) that took place at the University of Potsdam in 2015, illustrate the advancement of Slavic linguistic studies and their outreach for the development of general linguistics. The guest paper by Noam Chomsky at the beginning of the book sets a clear sign in this direction and may be taken as an acknowledgement of the field. Y1 - 2020 SN - 978-3-631-67673-8 SN - 978-3-631-70974-0 SN - 978-3-631-70975-7 SN - 978-3-6530-7147-4 U6 - https://doi.org/10.3726/978-3-653-07147-4 SN - 1862-524X VL - 29 PB - Peter Lang CY - Berlin ER - TY - CHAP A1 - Krause, Hannes-Vincent A1 - Große Deters, Fenne A1 - Baumann, Annika T1 - The envy spiral BT - unraveling the black box of social media positivityorganizations T2 - Proceedings of the 28th European Conference on Information Systems (ECIS) : ECIS 2020 Research-in-Progress Papers N2 - On Social Networking Sites (SNS) users disclose mostly positive and often self-enhancing information. Scholars refer to this phenomenon as the positivity bias in SNS communication (PBSC). However, while theoretical explanations for this phenomenon have been proposed, an empirical proof of these theorized mechanisms is still missing. The project presented in this Research-in-Progress paper aims at explaining the PBSC with the mechanism specified in the self-enhancement envy spiral. Specifically, we hypothesize that feelings of envy drive people to post positive and self-enhancing content on SNS. To test this hypothesis, we developed an experimental design allowing to examine the causal effect of envy on the positivity of users’ subsequently posted content. In a preliminary study, we tested our manipulation of envy and could show its effectiveness in inducing different levels of envy between our groups. Our project will help to broaden the understanding of the complex dynamics of SNS and the potentially adverse driving forces underlying them. Y1 - 2020 UR - https://aisel.aisnet.org/ecis2020_rip/68 SN - 978-1-7336325-1-5 PB - AIS Electronic Library (AISeL) CY - [Erscheinungsort nicht ermittelbar] ER - TY - CHAP A1 - Vladova, Gergana A1 - Rüdian, Sylvio Leo T1 - From learners to educators BT - development of online courses by students for students T2 - The future of education N2 - The rapid growth of technology and its evolving potential to support the transformation of teaching and learning in post-secondary institutions is a major challenge to the basic understanding of both the university and the communities it serves. In higher education, the standard forms of learning and teaching are increasingly being challenged and a more comprehensive process of differentiation is taking place. Student-centered teaching methods are becoming increasingly important in course design and the role of the lecturer is changing from the knowledge mediator to moderator and learning companion. However, this is accelerating the need for strategically planned faculty support and a reassessment of the role of teaching and learning. Even though the benefits of experience-based learning approaches for the development of life skills are well known, most knowledge transfer is still realized through lectures in higher education. Teachers have the goal to design the curriculum, new assignments, and share insights into evolving pedagogy. Student engagement could be the most important factor in the learning success of university students, regardless of the university program or teaching format. Against this background, this article presents the development, application, and initial findings of an innovative learning concept. In this concept, students are allowed to deal with a scientific topic, but instead of a presentation and a written elaboration, their examination consists of developing an online course in terms of content, didactics, and concept to implement it in a learning environment, which is state of the art. The online courses include both self-created teaching material and interactive tasks. The courses are created to be available to other students as learning material after a review process and are thus incorporated into the curriculum. KW - future curriculum KW - digitalization KW - online courses KW - COVID-19 Y1 - 2020 UR - https://conference.pixel-online.net/files/foe/ed0010/FP/6824-CUD4792-FP-FOE10.pdf SN - 978-88-85813-87-8 U6 - https://doi.org/10.26352/E618_2384-9509 SN - 2420-9732 VL - 10 PB - Pixel CY - Florenz ER - TY - CHAP A1 - Grum, Marcus A1 - Blunk, Oliver A1 - Rojahn, Marcel A1 - Fettke, Peter A1 - Gronau, Norbert T1 - Research challenges of knowledge modelling and the outline of a research agenda T2 - Knowledge in digital age : IFKAD 2020 KW - knowledge management KW - process modelling KW - research challenges Y1 - 2020 SN - 978-88-96687-13-0 SN - 2280-787X PB - The Arts of Business Institute CY - Matera, Italy ER - TY - CHAP A1 - Schenke, Maren A1 - Schjeide, Brit-Maren A1 - Püschel, Gerhard A1 - Seeger, Bettina T1 - Human motor neurons diffentiated from plutipotent stem cells as superior traged cells for botulinum neuotoxin potency testing BT - In: German Pharm-Tox Summit 2020: abstracts of the 86th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) T2 - Naunyn-Schmiedeberg's archives of pharmacology Y1 - 2020 U6 - https://doi.org/10.1007/s00210-020-01828-y SN - 0028-1298 SN - 1432-1912 VL - 393 IS - SUPPL 1 SP - 10 EP - 10 PB - Springer CY - Berlin ; Heidelberg ER - TY - CHAP A1 - Abramova, Olga T1 - Does a smile open all doors? BT - understanding the impact of appearance disclosure on accommodation sharing platforms T2 - Proceedings of the 53rd Hawaii International Conference on System Sciences N2 - Online photographs govern an individual’s choices across a variety of contexts. In sharing arrangements, facial appearance has been shown to affect the desire to collaborate, interest to explore a listing, and even willingness to pay for a stay. Because of the ubiquity of online images and their influence on social attitudes, it seems crucial to be able to control these aspects. The present study examines the effect of different photographic self-disclosures on the provider’s perceptions and willingness to accept a potential co-sharer. The findings from our experiment in the accommodation-sharing context suggest social attraction mediates the effect of photographic self-disclosures on willingness to host. Implications of the results for IS research and practitioners are discussed. KW - The Sharing Economy KW - airbnb KW - online photographs KW - self-disclosure KW - sharing economy KW - social attraction Y1 - 2020 SN - 978-0-9981331-3-3 SP - 831 EP - 840 PB - HICSS Conference Office University of Hawaii at Manoa CY - Honolulu ER - TY - CHAP A1 - Rungrottheera, Wannarut A1 - Chang, Der-Chen A1 - Schulze, Bert-Wolfgang T1 - The edge calculus of singularity order >3 T2 - Journal of nonlinear and convex analysis : an international journal N2 - We study Mellin pseudo-differential algebras on singular straight cones and manifolds with singularity of order >= 3. Those are necessary to express parametrices of elliptic differential operators with a corresponding cornerdegenerate behavior, and we obtain regularity in weighted spaces. KW - Pseudo-differential algebras KW - symbols KW - singular manifolds KW - Mellin KW - operator calculus Y1 - 2020 SN - 1345-4773 SN - 1880-5221 VL - 21 IS - 2 SP - 387 EP - 401 PB - Yokohama Publishers CY - Yokohama ER - TY - CHAP A1 - Baum, Katharina A1 - Köster, Antonia A1 - Krasnova, Hanna A1 - Tarafdar, Monideepa T1 - Living in a world of plenty? BT - how social network sites use distorts perceptions of wealth inequality T2 - Proceedings of the 28th European Conference on Information Systems (ECIS) : ECIS 2020 Research Papers N2 - Inequality in the distribution of economic wealth within populations has been rising steadily over the past century, having reached unprecedented highs in many Western societies. However, this development is not reflected in people’s perceptions of wealth inequality, as the public tends to underestimate it. Research suggests that inequality estimates are derived from personal reference groups, which, as we propose, are expanded by social network site (SNS) use. As content on SNSs frequently revolves around events of consumption, signaling enhanced overall population wealth, this study tests the hypothesis that SNS use distorts inequality perceptions downward, i.e., increases the perception of societal equality. Responses of 534 survey participants in the United States confirm that SNS use negatively predicts perceived inequality. The relationship is stronger the more SNS users perceive the content they encounter online as real, supporting the assumption that observing other people’s behavior online lowers estimates of nationwide wealth inequality. These findings provide novel insights on inequality misperceptions by suggesting individuals’ SNS use as a new predictor of perceived wealth inequality. Y1 - 2020 UR - https://aisel.aisnet.org/ecis2020_rp/199 PB - AIS Electronic Library (AISeL) CY - [Erscheinungsort nicht ermittelbar] ER - TY - CHAP A1 - Risch, Lucie A1 - Bashford, Greg A1 - Kulig, Kornelia A1 - Kaplick, Hannes A1 - Mayer, Frank A1 - Cassel, Michael T1 - Spatial frequency analysis identifies altered local Micromorphology in adolescent athletes with Achilles tendinopathy T2 - Medicine and science in sports and exercise : MSSE ; official journal of the American College of Sports Medicine Y1 - 2020 U6 - https://doi.org/10.1249/01.mss.0000670932.99564.57 SN - 0195-9131 SN - 1530-0315 VL - 52 SP - 82 EP - 82 PB - Lippincott Williams & Wilkins CY - Philadelphia ER -