TY - JOUR A1 - Kleinpeter, Erich A1 - Pihlaja, Kalevi A1 - Sinkkonen, Jari A1 - Stájer, Gezá A1 - Koch, Andreas T1 - 1-Oxo-1,3-dithiolanesùsynthesis and stereochemistry N2 - 1-Oxo-1,3-dithiolane (4) and its cis- andtrans-2-methyl (5,6), -4-methyl (7,8) and -5-methyl (9,10) derivatives were prepared by oxidizing the corresponding 1,3-dithiolanes (1-3) with NaIO4 in water. The oxides were purified and their isomers separated using thin layer chromatography. The structural characterization was carried out with 1H and 13C NMR spectroscopy and molecular modelling. The sulfoxides 4-6 and 8-10 attain two S(1) type envelopes (sometimes slightly distorted) the S=Oax envelope greatly dominating. Cis-4-methyl-1-oxo-1,3-dithiolane is a special case exhibiting both two closely related S=Oax (30 and 27%) as well as S=Oeq (21 and 22%) forms [S(1) and C(4) envelopes, respectively]. The relative energies of these conformations, the values of 1H-1H coupling constants and 1H and 13C chemical shifts were estimated by computational methods and they support well the conclusions based on the experimental data. Y1 - 2011 SN - 0749-1581 ER - TY - JOUR A1 - Pihlaja, Kalevi A1 - Sinkkonen, Jari A1 - Stajer, Geza A1 - Koch, Andreas A1 - Kleinpeter, Erich T1 - 1-Oxo-1,3-dithiolanes - synthesis and stereochemistry JF - Magnetic resonance in chemistry N2 - 1-Oxo-1,3-dithiolane (4) and its cis- and trans-2-methyl (5,6), -4-methyl (7,8) and -5-methyl (9,10) derivatives were prepared by oxidizing the corresponding 1,3-dithiolanes (1-3) with NaIO(4) in water. The oxides were purified and their isomers separated using thin layer chromatography. The structural characterization was carried out with (1)H and (13)C NMR spectroscopy and molecular modelling. The sulfoxides 4-6 and 8-10 attain two S(1) type envelopes (sometimes slightly distorted) the S=O(ax) envelope greatly dominating. Cis-4-methyl-1-oxo-1,3-dithiolane is a special case exhibiting both two closely related S=O(ax) (30 and 27%) as well as S=O(eq) (21 and 22%) forms [S(1) and C(4) envelopes, respectively]. The relative energies of these conformations, the values of (1)H-(1)H coupling constants and (1)H and (13)C chemical shifts were estimated by computational methods and they support well the conclusions based on the experimental data. KW - NMR KW - (1)H NMR KW - (13)C NMR KW - sulfur heterocycles KW - conformational analysis KW - computational chemistry Y1 - 2011 U6 - https://doi.org/10.1002/mrc.2764 SN - 0749-1581 VL - 49 IS - 7 SP - 443 EP - 449 PB - Wiley-Blackwell CY - Malden ER - TY - JOUR A1 - Zebger-Gong, Hong A1 - Mueller, Dominik A1 - Diercke, Michaela A1 - Haffner, Dieter A1 - Hocher, Berthold A1 - Verberckmoes, Steven A1 - Schmidt, Sven A1 - D'Haese, Patrick C. A1 - Querfeld, Uwe T1 - 1,25-Dihydroxyvitamin D-3-induced aortic calcifications in experimental uremia: up-regulation of osteoblast markers, calcium-transporting proteins and osterix JF - Journal of hypertension N2 - Background and objective Whether treatment with vitamin D receptor activators contributes to cardiovascular disease in patients with chronic kidney disease is a matter of debate. We studied mechanisms involved in vitamin D-related vascular calcifications in vivo and in vitro. Methods Aortic calcifications were induced in subtotally nephrectomized (SNX) rats by treatment with a high dose (0.25 mu g/kg per day) of 1,25-dihydroxyvitamin D-3 (calcitriol) given for 6 weeks. Likewise, primary rat vascular smooth muscle cells (VSMCs) were incubated with calcitriol at concentrations ranging from 10(-11) to 10(-7) mol/l. Immunohistochemistry revealed that the aortic expression of osteopontin, osteocalcin and bone sialoprotein was significantly increased in calcitriol-treated SNX rats compared to untreated SNX controls. In addition, aortic expression of the transient receptor potential vanilloid calcium channel 6 (TRPV6) and calbindin D9k was significantly up-regulated by treatment with calcitriol. Furthermore, calcitriol significantly increased expression of the osteogenic transcription factor osterix. In-vitro studies showed similar results, confirming that these effects could be attributed to treatment with calcitriol. Conclusions High-dose calcitriol treatment induces an osteoblastic phenotype in VSMC both in SNX rats and in vitro, associated with up-regulation of proteins regulating mineralization and calcium transport, and of the osteogenic transcription factor osterix. KW - calbindin D9k KW - calcitriol KW - calcium transport KW - osteoblast KW - osterix KW - TRPV5 KW - TRPV6 KW - vascular calcification Y1 - 2011 U6 - https://doi.org/10.1097/HJH.0b013e328340aa30 SN - 0263-6352 VL - 29 IS - 2 SP - 339 EP - 348 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Prickett, David James T1 - 'We will show you Berlin' space, leisure, flanerie and sexuality JF - Leisure studies : the journal of the Leisure Studies Association N2 - Both the seat of the German government and the capitol of queer German culture, Berlin has been that spatial nexus of politics, sexuality and gender, work and leisure that has enabled the development of multifarious sexual and gender identities. This has caused celebration and consternation among Germans and foreigners alike. Contemporary studies of urban homosexual space cite an erosion of its 'authenticity' when cities market homosexual space in order to attract tourists. My literary analysis shows that Berlin's homosexual male culture and space had already been subject to commoditisation in the Weimar period (1918-1933), when Berliners discovered marketing potential in the French slight la vice allemand [the German vice] - male homosexuality. This article's examination of Weimar Berlin's spatial binary as 'sexy space' and 'sexualised place' in literature by Klaus Mann and Curt Moreck engages with current debates in leisure studies on the gendering and sexing of geography and leisure. Central to this re-evaluation of leisure and tourism in Weimar Berlin is my discussion of flanerie: the figure of the flaneuse indicates that flanerie was not the lone dominion of heterosexual men. In the context of urban leisure and male homosexuality, I argue that Weimar Berlin consistently and successfully negotiated its dual function of sexy space (allowing self-fashioning for homosexual men in Berlin) and sexualised place (voyeurism and sexual exploration for Berlin's newcomers and tourists). KW - tourism KW - consumer culture KW - gender KW - geography KW - history KW - arts Y1 - 2011 U6 - https://doi.org/10.1080/02614367.2010.523836 SN - 0261-4367 VL - 30 IS - 2 SP - 157 EP - 177 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Raphael-Hernandez, Heike T1 - "White America graciously giving way to its non-white future" : when Hollywood attempts to go postcolonial Y1 - 2011 SN - 978-3-631-60743-5 ER - TY - JOUR A1 - Kunow, Rüdiger T1 - "Unavoidably side by side" : Mobility Studies-Concepts and Issues Y1 - 2011 SN - 978-3-86956-090-8 ER - TY - JOUR A1 - Kunow, Rüdiger T1 - "Unavoidably side by side" BT - mobility studies – concepts and issues JF - Mobilisierte Kulturen Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-57317 SN - 2192-3019 SN - 2192-3027 IS - 1 SP - 17 EP - 32 ER - TY - JOUR A1 - Weber, Nancy A1 - Tiersch, Brigitte A1 - Unterlass, Miriam M. A1 - Heilig, Anneliese A1 - Tauer, Klaus T1 - "Schizomorphic" Emulsion Copolymerization Particles JF - Macromolecular rapid communications N2 - Cryo-electron microscopy, atomic force microscopy, and light microscopy investigations provide experimental evidence that amphiphilic emulsion copolymerization particles change their morphology in dependence on concentration. The shape of the particles is spherical at solids content above 1%, but it changes to rod-like, ring-like, and web-like structures at lower concentrations. In addition, the shape and morphology of these particles at low concentrations are not fixed but very flexible and vary with time between spheres, flexible pearlnecklace structures, and stretched rods. KW - amphiphilic particles KW - emulsion polymerization KW - morphology Y1 - 2011 U6 - https://doi.org/10.1002/marc.201100491 SN - 1022-1336 VL - 32 IS - 23 SP - 1925 EP - 1929 PB - Wiley-Blackwell CY - Malden ER - TY - JOUR A1 - Petsche, Hans-Joachim T1 - "It's all coming together now..." : converging networks and the network of convergence Y1 - 2011 SN - 978-3-86644-731-8 ER - TY - JOUR A1 - Kunow, Rüdiger A1 - Hartung, Heike T1 - "Introduction : Age Studies " Y1 - 2011 SN - 0340-2827 ER -