TY  - JOUR
A1  - Rödel, Claudia Jasmin
A1  - Otten, Cecile
A1  - Donat, Stefan
A1  - Lourenço, Marta Sofia Rocha
A1  - Fischer, Dorothea
A1  - Kuropka, Benno
A1  - Paolini, Alessio
A1  - Freund, Christian
A1  - Abdelilah-Seyfried, Salim
T1  - Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations
JF  - Circulation Research
N2  - RATIONALE: Pathological biomechanical signaling induces vascular anomalies including cerebral cavernous malformations (CCM), which are caused by a clonal loss of CCM1/KRIT1 (Krev interaction trapped protein 1), CCM2/MGC4607, or CCM3/PDCD10. Why patients typically experience lesions only in lowly perfused venous capillaries of the cerebrovasculature is completely unknown. OBJECTIVE: In contrast, animal models with a complete loss of CCM proteins lack a functional heart and blood flow and exhibit vascular anomalies within major blood vessels as well. This finding raises the possibility that hemodynamics may play a role in the context of this vascular pathology. METHODS AND RESULTS: Here, we used a genetic approach to restore cardiac function and blood flow in a zebrafish model of CCM1. We find that blood flow prevents cardiovascular anomalies including a hyperplastic expansion within a large Ccm1-deficient vascular bed, the lateral dorsal aorta. CONCLUSIONS: This study identifies blood flow as an important physiological factor that is protective in the cause of this devastating vascular pathology.
KW  - animal models
KW  - cerebral cavernous malformations
KW  - endothelial cell
KW  - hemodynamics
KW  - zebrafish
Y1  - 2019
U6  - https://doi.org/10.1161/CIRCRESAHA.119.315076
SN  - 0009-7330
SN  - 1524-4571
VL  - 125
IS  - 10
SP  - E43
EP  - E54
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Lachmuth, Susanne
A1  - Durka, Walter
A1  - Schurr, Frank Martin
T1  - Differentiation of reproductive and competitive ability in the invaded range of Senecio inaequidens  the role of genetic Allee effects, adaptive and nonadaptive evolution
JF  - New phytologist : international journal of plant science
N2  - Genetic differentiation in the competitive and reproductive ability of invading populations can result from genetic Allee effects or r/K selection at the local or range-wide scale. However, the neutral relatedness of populations may either mask or falsely suggest adaptation and genetic Allee effects.
 In a common-garden experiment, we investigated the competitive and reproductive ability of invasive Senecio inaequidens populations that vary in neutral genetic diversity, population age and field vegetation cover. To account for population relatedness, we analysed the experimental results with 'animal models' adopted from quantitative genetics.
 Consistent with adaptive r/K differentiation at local scales, we found that genotypes from low-competition environments invest more in reproduction and are more sensitive to competition. By contrast, apparent effects of large-scale r/K differentiation and apparent genetic Allee effects can largely be explained by neutral population relatedness.
 Invading populations should not be treated as homogeneous groups, as they may adapt quickly to small-scale environmental variation in the invaded range. Furthermore, neutral population differentiation may strongly influence invasion dynamics and should be accounted for in analyses of common-garden experiments.
KW  - animal models
KW  - biological invasions
KW  - genetic Allee effects
KW  - interspecific competition
KW  - life history evolution
KW  - nonadaptive evolution
KW  - r and K selection
KW  - reproduction
Y1  - 2011
U6  - https://doi.org/10.1111/j.1469-8137.2011.03808.x
SN  - 0028-646X
VL  - 192
IS  - 2
SP  - 529
EP  - 541
PB  - Wiley-Blackwell
CY  - Malden
ER  -