TY  - JOUR
A1  - Polley, Nabarun
A1  - Basak, Supratim
A1  - Hass, Roland
A1  - Pacholski, Claudia
T1  - Fiber optic plasmonic sensors
BT  - Providing sensitive biosensor platforms with minimal lab equipment
JF  - Biosensors and bioelectronics : the principal international journal devoted to research, design development and application of biosensors and bioelectronics
N2  - A simple, convenient, and inexpensive method to fabricate optical fiber based biosensors which utilize periodic hole arrays in gold films for signal transduction is reported. The process of hole array formation mainly relies on self-assembly of hydrogel microgels in combination with chemical gold film deposition and subsequent transfer of the perforated film onto an optical fiber tip. In the fabrication process solely chemical wet lab techniques are used, avoiding cost-intensive instrumentation or clean room facilities. The presented method for preparing fiber optic plasmonic sensors provides high throughput and is perfectly suited for commercialization using batch processing. The transfer of the perforated gold film onto an optical fiber tip does not affect the sensitivity of the biosensor ((420 +/- 83) nm/refractive index unit (RIU)), which is comparable to sensitivities of sensor platforms based on periodic hole arrays in gold films prepared by significantly more complex methods. Furthermore, real-time and in-line immunoassay studies with a specially designed 3D printed flow cell are presented exploiting the presented optical fiber based biosensors.
KW  - Surface plasmon resonance
KW  - Optical fiber
KW  - Bottom-up fabrication
KW  - Biosensor
KW  - 3D printed flow-cell
Y1  - 2019
U6  - https://doi.org/10.1016/j.bios.2019.03.020
SN  - 0956-5663
SN  - 1873-4235
VL  - 132
SP  - 368
EP  - 374
PB  - Elsevier
CY  - Oxford
ER  -