TY  - GEN
A1  - Weyrich, Alexandra
A1  - Jeschek, Marie
A1  - Schrapers, Katharina T.
A1  - Lenz, Dorina
A1  - Chung, Tzu Hung
A1  - Ruebensam, Kathrin
A1  - Yasar, Sermin
A1  - Schneemann, Markus
A1  - Ortmann, Sylvia
A1  - Jewgenow, Katarina
A1  - Fickel, Jörns
T1  - Diet changes alter paternally inherited epigenetic pattern in male Wild guinea pigs
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Epigenetic modifications, of which DNA methylation is the most stable, are a mechanism conveying environmental information to subsequent generations via parental germ lines. The paternal contribution to adaptive processes in the offspring might be crucial, but has been widely neglected in comparison to the maternal one. To address the paternal impact on the offspring's adaptability to changes in diet composition, we investigated if low protein diet (LPD) in F0 males caused epigenetic alterations in their subsequently sired sons. We therefore fed F0 male Wild guinea pigs with a diet lowered in protein content (LPD) and investigated DNA methylation in sons sired before and after their father's LPD treatment in both, liver and testis tissues. Our results point to a 'heritable epigenetic response' of the sons to the fathers' dietary change. Because we detected methylation changes also in the testis tissue, they are likely to be transmitted to the F2 generation. Gene-network analyses of differentially methylated genes in liver identified main metabolic pathways indicating a metabolic reprogramming ('metabolic shift'). Epigenetic mechanisms, allowing an immediate and inherited adaptation may thus be important for the survival of species in the context of a persistently changing environment, such as climate change.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1065 
KW  - DNA methylation
KW  - exposure
KW  - wild mammal species
KW  - inheritance
KW  - plasticity
KW  - adaptation
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-460031
SN  - 1866-8372
IS  - 1065
ER  -