TY  - JOUR
A1  - Matkovic, Aleksandar
A1  - Vasic, Borislav
A1  - Pesic, Jelena
A1  - Prinz, Julia
A1  - Bald, Ilko
A1  - Milosavljevic, Aleksandar R.
A1  - Gajic, Rados
T1  - Enhanced structural stability of DNA origami nanostructures by graphene encapsulation
JF  - NEW JOURNAL OF PHYSICS
N2  - We demonstrate that a single-layer graphene replicates the shape of DNA origami nanostructures very well. It can be employed as a protective layer for the enhancement of structural stability of DNA origami nanostructures. Using the AFM based manipulation, we show that the normal force required to damage graphene encapsulated DNA origami nanostructures is over an order of magnitude greater than for the unprotected ones. In addition, we show that graphene encapsulation offers protection to the DNA origami nanostructures against prolonged exposure to deionized water, and multiple immersions. Through these results we demonstrate that graphene encapsulated DNA origami nanostructures are strong enough to sustain various solution phase processing, lithography and transfer steps, thus extending the limits of DNA-mediated bottom-up fabrication.
KW  - graphene
KW  - DNA origami nanostructures
KW  - atomic force microscopy
Y1  - 2016
U6  - https://doi.org/10.1088/1367-2630/18/2/025016
SN  - 1367-2630
VL  - 18
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - GEN
A1  - Bald, Ilko
A1  - Keller, Adrian
T1  - Molecular processes studied at a single-molecule level using DNA origami nanostructures and atomic force microscopy
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - DNA origami nanostructures allow for the arrangement of different functionalities such as proteins, specific DNA structures, nanoparticles, and various chemical modifications with unprecedented precision. The arranged functional entities can be visualized by atomic force microscopy (AFM) which enables the study of molecular processes at a single-molecular level. Examples comprise the investigation of chemical reactions, electron-induced bond breaking, enzymatic binding and cleavage events, and conformational transitions in DNA. In this paper, we provide an overview of the advances achieved in the field of single-molecule investigations by applying atomic force microscopy to functionalized DNA origami substrates.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1146 
KW  - DNA origami
KW  - atomic force microscopy
KW  - single-molecule analysis
KW  - DNA radiation damage
KW  - protein binding
KW  - enzyme reactions
KW  - G quadruplexes
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-475843
SN  - 1866-8372
IS  - 9
SP  - 13803
EP  - 13823
ER  - 
TY  - JOUR
A1  - Bald, Ilko
A1  - Keller, Adrian
T1  - Molecular processes studied at a single-molecule level using DNA origami nanostructures and atomic force microscopy
JF  - Molecules
N2  - DNA origami nanostructures allow for the arrangement of different functionalities such as proteins, specific DNA structures, nanoparticles, and various chemical modifications with unprecedented precision. The arranged functional entities can be visualized by atomic force microscopy (AFM) which enables the study of molecular processes at a single-molecular level. Examples comprise the investigation of chemical reactions, electron-induced bond breaking, enzymatic binding and cleavage events, and conformational transitions in DNA. In this paper, we provide an overview of the advances achieved in the field of single-molecule investigations by applying atomic force microscopy to functionalized DNA origami substrates.
KW  - DNA origami
KW  - atomic force microscopy
KW  - single-molecule analysis
KW  - DNA radiation damage
KW  - protein binding
KW  - enzyme reactions
KW  - G quadruplexes
Y1  - 2014
U6  - https://doi.org/10.3390/molecules190913803
SN  - 1420-3049
VL  - 19
IS  - 9
SP  - 13803
EP  - 13823
PB  - MDPI
CY  - Basel
ER  -