TY - JOUR A1 - Bandyopadhyay, Soumyadip A1 - Sarkar, Dipankar A1 - Mandal, Chittaranjan A1 - Giese, Holger T1 - Translation validation of coloured Petri net models of programs on integers JF - Acta informatica N2 - Programs are often subjected to significant optimizing and parallelizing transformations based on extensive dependence analysis. Formal validation of such transformations needs modelling paradigms which can capture both control and data dependences in the program vividly. Being value-based with an inherent scope of capturing parallelism, the untimed coloured Petri net (CPN) models, reported in the literature, fit the bill well; accordingly, they are likely to be more convenient as the intermediate representations (IRs) of both the source and the transformed codes for translation validation than strictly sequential variable-based IRs like sequential control flow graphs (CFGs). In this work, an efficient path-based equivalence checking method for CPN models of programs on integers is presented. Extensive experimentation has been carried out on several sequential and parallel examples. Complexity and correctness issues have been treated rigorously for the method. Y1 - 2022 U6 - https://doi.org/10.1007/s00236-022-00419-z SN - 0001-5903 SN - 1432-0525 VL - 59 IS - 6 SP - 725 EP - 759 PB - Springer CY - New York ER - TY - JOUR A1 - Barnes, Jan A1 - Kennewell, Steve T1 - Teacher Perceptions of Key Competencies in ICT JF - KEYCIT 2014 - Key Competencies in Informatics and ICT N2 - Regardless of what is intended by government curriculum specifications and advised by educational experts, the competencies taught and learned in and out of classrooms can vary considerably. In this paper, we discuss in particular how we can investigate the perceptions that individual teachers have of competencies in ICT, and how these and other factors may influence students’ learning. We report case study research which identifies contradictions within the teaching of ICT competencies as an activity system, highlighting issues concerning the object of the curriculum, the roles of the participants and the school cultures. In a particular case, contradictions in the learning objectives between higher order skills and the use of application tools have been resolved by a change in the teacher’s perceptions which have not led to changes in other aspects of the activity system. We look forward to further investigation of the effects of these contradictions in other case studies and on forthcoming curriculum change. KW - ICT competencies KW - Teacher perceptions KW - Activity Theory KW - Contradictions Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-82604 SN - 1868-0844 SN - 2191-1940 IS - 7 SP - 61 EP - 75 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Bauer, Chris A1 - Herwig, Ralf A1 - Lienhard, Matthias A1 - Prasse, Paul A1 - Scheffer, Tobias A1 - Schuchhardt, Johannes T1 - Large-scale literature mining to assess the relation between anti-cancer drugs and cancer types JF - Journal of translational medicine N2 - Background: There is a huge body of scientific literature describing the relation between tumor types and anti-cancer drugs. The vast amount of scientific literature makes it impossible for researchers and physicians to extract all relevant information manually. Methods: In order to cope with the large amount of literature we applied an automated text mining approach to assess the relations between 30 most frequent cancer types and 270 anti-cancer drugs. We applied two different approaches, a classical text mining based on named entity recognition and an AI-based approach employing word embeddings. The consistency of literature mining results was validated with 3 independent methods: first, using data from FDA approvals, second, using experimentally measured IC-50 cell line data and third, using clinical patient survival data. Results: We demonstrated that the automated text mining was able to successfully assess the relation between cancer types and anti-cancer drugs. All validation methods showed a good correspondence between the results from literature mining and independent confirmatory approaches. The relation between most frequent cancer types and drugs employed for their treatment were visualized in a large heatmap. All results are accessible in an interactive web-based knowledge base using the following link: . Conclusions: Our approach is able to assess the relations between compounds and cancer types in an automated manner. Both, cancer types and compounds could be grouped into different clusters. Researchers can use the interactive knowledge base to inspect the presented results and follow their own research questions, for example the identification of novel indication areas for known drugs. KW - Literature mining KW - Anti-cancer drugs KW - Tumor types KW - Word embeddings KW - Database Y1 - 2021 U6 - https://doi.org/10.1186/s12967-021-02941-z SN - 1479-5876 VL - 19 IS - 1 PB - BioMed Central CY - London ER - TY - BOOK A1 - Becker, Basil T1 - Model-based extension of AUTOSAR for architectural online reconfiguration Y1 - 2010 SN - 978-3-86956-036-6 ER - TY - JOUR A1 - Beerenwinkel, Niko A1 - Sing, Tobias A1 - Lengauer, Thomas A1 - Rahnenfuhrer, Joerg A1 - Roomp, Kirsten A1 - Savenkov, Igor A1 - Fischer, Roman A1 - Hoffmann, Daniel A1 - Selbig, Joachim A1 - Korn, Klaus A1 - Walter, Hauke A1 - Berg, Thomas A1 - Braun, Patrick A1 - Faetkenheuer, Gerd A1 - Oette, Mark A1 - Rockstroh, Juergen A1 - Kupfer, Bernd A1 - Kaiser, Rolf A1 - Daeumer, Martin T1 - Computational methods for the design of effective therapies against drug resistant HIV strains N2 - The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data Y1 - 2005 ER - TY - JOUR A1 - Benhammadi, Farid A1 - Nicolas, Pascal A1 - Schaub, Torsten T1 - Extension calculus and query answering in prioritized default logic Y1 - 1998 SN - 3-540- 64993-X ER - TY - JOUR A1 - Benhammadi, Farid A1 - Nicolas, Pascal A1 - Schaub, Torsten T1 - Extension calculus and query answering in prioritized default logic Y1 - 1998 SN - 3-540-64993-X ER - TY - JOUR A1 - Benhammadi, Farid A1 - Nicolas, Pascal A1 - Schaub, Torsten T1 - Query-answering in prioritized default logic Y1 - 1999 SN - 3-540-66131-X ER - TY - JOUR A1 - Benhammadi, Farid A1 - Nicolas, Pascal A1 - Schaub, Torsten T1 - Query-answering in prioritized default logic Y1 - 1999 SN - 3-540-66131-X ER - TY - THES A1 - Bensch, Suna T1 - Parallel systems as mildly context-sensitive grammar formalisms Y1 - 2008 ER -