TY  - GEN
A1  - Behm, David George
A1  - Mühlbauer, Thomas
A1  - Kibele, Armin
A1  - Granacher, Urs
T1  - Effects of Strength Training Using Unstable Surfaces on Strength, Power and Balance Performance Across the Lifespan: A Systematic Review and Meta-analysis (vol 45, pg 1645, 2015)
T2  - Sports medicine
Y1  - 2016
U6  - https://doi.org/10.1007/s40279-016-0497-x
SN  - 0112-1642
SN  - 1179-2035
VL  - 46
SP  - 451
EP  - 451
PB  - Springer
CY  - Northcote
ER  - 
TY  - GEN
A1  - Anderson, Christopher J.
A1  - Bahnik, Stepan
A1  - Barnett-Cowan, Michael
A1  - Bosco, Frank A.
A1  - Chandler, Jesse
A1  - Chartier, Christopher R.
A1  - Cheung, Felix
A1  - Christopherson, Cody D.
A1  - Cordes, Andreas
A1  - Cremata, Edward J.
A1  - Della Penna, Nicolas
A1  - Estel, Vivien
A1  - Fedor, Anna
A1  - Fitneva, Stanka A.
A1  - Frank, Michael C.
A1  - Grange, James A.
A1  - Hartshorne, Joshua K.
A1  - Hasselman, Fred
A1  - Henninger, Felix
A1  - van der Hulst, Marije
A1  - Jonas, Kai J.
A1  - Lai, Calvin K.
A1  - Levitan, Carmel A.
A1  - Miller, Jeremy K.
A1  - Moore, Katherine S.
A1  - Meixner, Johannes M.
A1  - Munafo, Marcus R.
A1  - Neijenhuijs, Koen I.
A1  - Nilsonne, Gustav
A1  - Nosek, Brian A.
A1  - Plessow, Franziska
A1  - Prenoveau, Jason M.
A1  - Ricker, Ashley A.
A1  - Schmidt, Kathleen
A1  - Spies, Jeffrey R.
A1  - Stieger, Stefan
A1  - Strohminger, Nina
A1  - Sullivan, Gavin B.
A1  - van Aert, Robbie C. M.
A1  - van Assen, Marcel A. L. M.
A1  - Vanpaemel, Wolf
A1  - Vianello, Michelangelo
A1  - Voracek, Martin
A1  - Zuni, Kellylynn
T1  - Response to Comment on "Estimating the reproducibility of psychological science"
T2  - Science
N2  - Gilbert et al. conclude that evidence from the Open Science Collaboration’s Reproducibility Project: Psychology indicates high reproducibility, given the study methodology. Their very optimistic assessment is limited by statistical misconceptions and by causal inferences from selectively interpreted, correlational data. Using the Reproducibility Project: Psychology data, both optimistic and pessimistic conclusions about reproducibility are possible, and neither are yet warranted.
Y1  - 2016
U6  - https://doi.org/10.1126/science.aad9163
SN  - 0036-8075
SN  - 1095-9203
VL  - 351
SP  - 1162
EP  - 1165
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - GEN
A1  - Wippert, Pia-Maria
A1  - Puschmann, Anne-Katrin
A1  - Schiltenwolf, Marcus
A1  - Wiebking, Christine
A1  - Mayer, Frank
T1  - BACK PAIN: THE STUDY OF MECHANISMS AND THE TRANSLATION IN INTERVENTIONS WITHIN THE MISPEX NETWORK
T2  - Psychosomatic medicine
Y1  - 2016
SN  - 0033-3174
SN  - 1534-7796
VL  - 78
SP  - A91
EP  - A91
PB  - Elsevier
CY  - Philadelphia
ER  - 
TY  - GEN
A1  - Puschmann, Anne-Katrin
A1  - Wippert, Pia-Maria
T1  - A LONGITUDINAL INTERDISCIPLINARY APPROACH TO STRESS AND ITS IMPACT ON THE DEVELOPMENT OF CHRONIC PAIN
T2  - Psychosomatic medicine
Y1  - 2016
SN  - 0033-3174
SN  - 1534-7796
VL  - 78
SP  - A91
EP  - A91
PB  - Routledge, Taylor & Francis Group
CY  - Philadelphia
ER  - 
TY  - GEN
A1  - Battiston, Stefano
A1  - Farmer, Doyne
A1  - Flache, Andreas
A1  - Garlaschelli, Diego
A1  - Haldane, Andy
A1  - Heesterbeek, Hans
A1  - Hommes, Cars
A1  - Jaeger, Carlo
A1  - May, Robert
A1  - Scheffer, Marten
T1  - Financial complexity: Accounting for fraud Response
T2  - Science
Y1  - 2016
U6  - https://doi.org/10.1126/science.352.6283.302
SN  - 0036-8075
SN  - 1095-9203
VL  - 352
SP  - 302
EP  - 302
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - GEN
A1  - Levermann, Anders
A1  - Petoukhov, Vladimir
A1  - Schewe, Jacob
A1  - Schellnhuber, Hans Joachim
T1  - Abrupt monsoon transitions as seen in paleorecords can be explained by moisture-advection feedback
T2  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 2016
U6  - https://doi.org/10.1073/pnas.1603130113
SN  - 0027-8424
VL  - 113
SP  - E2348
EP  - E2349
PB  - National Acad. of Sciences
CY  - Washington
ER  - 
TY  - GEN
A1  - Hartmann, Matthias
A1  - Fischer, Martin H.
T1  - Exploring the numerical mind by eye-tracking: a special issue
T2  - Psychological research : an international journal of perception, attention, memory, and action
Y1  - 2016
U6  - https://doi.org/10.1007/s00426-016-0759-0
SN  - 0340-0727
SN  - 1430-2772
VL  - 80
SP  - 325
EP  - 333
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - GEN
A1  - Stroehle, Andreas
A1  - Rapp, Michael A.
T1  - Prevention of Cognitive Decline: A Physical Exercise Perspective on Brain Health in the Long Run
T2  - Journal of the American Medical Directors Association
Y1  - 2016
U6  - https://doi.org/10.1016/j.jamda.2016.02.030
SN  - 1525-8610
SN  - 1538-9375
VL  - 17
SP  - 461
EP  - 462
PB  - Elsevier
CY  - New York
ER  - 
TY  - GEN
A1  - Maier, Natalia
A1  - Holzlöhner, Pamela
A1  - Hoenow, Anja
A1  - Scheunemann, Astrid
A1  - Weschke, Daniel
A1  - Hanack, Katja
T1  - Characterization of monoclonal antibodies generated by in vitro immunization
T2  - The journal of immunology
N2  - Monoclonal antibodies are highly valuable tools in biomedicine but the generation by hybridoma technology is very time-consuming and elaborate. In order to circumvent the consisting drawbacks an in vitro immunization approach was established by which murine as well as human monoclonal antibodies against a viral coat protein could be developed. The in vitro immunization process was performed by isolation of murine hematopoietic stem cells or human monocytes and an in vitro differentiation into immature dendritic cells. After antigen loading the cells were co-cultivated with naive T and B lymphocytes for three days in order to obtain antigen-specific B lymphocytes in culture, followed by fusion with murine myeloma cells or human/murine heteromyeloma cells. Antigen-specific hybridomas were selected and the generated antibodies were purified and characterized in this study by ELISA, western blot, gene sequencing, affinity measurements. Further the characteristics were compared to a monoclonal antibody against the same target generated by conventional hybridoma technology. Isotype detection revealed a murine IgM and a human IgG4 antibody in comparison to an IgG1 for the conventionally generated antibody. The antibodies derived from in vitro immunization showed indeed a lower affinity for the antigen as compared to the conventionally generated one, which is probably based on the significantly shorter B cell maturation (3 days) during the immunization process. Nevertheless, they were suitable for building up a sandwich based detection system. Therefore, the in vitro immunization approach seems to be a good and particularly fast alternative to conventional hybridoma technology.
Y1  - 2016
SN  - 0022-1767
SN  - 1550-6606
VL  - 196
PB  - American Assoc. of Immunologists
CY  - Bethesda
ER  - 
TY  - GEN
A1  - Hanack, Katja
A1  - Schloer, Anja
A1  - Holzloehner, Pamela
A1  - Listek, Martin
A1  - Bauer, Cindy
A1  - Butze, Monique
A1  - Micheel, Burkhard
A1  - Hentschel, Christian
A1  - Sowa, Mandy
A1  - Roggenbuck, Dirk
A1  - Schierack, Peter
A1  - Fuener, Jonas
A1  - Schliebs, Erik
A1  - Goihl, Alexander
A1  - Reinhold, Dirk
T1  - Camelid nanobodies specific to human pancreatic glycoprotein 2
T2  - The journal of immunology
N2  - Pancreatic secretory zymogen-granule membrane glycoprotein 2 (GP2) has been identified to be a major autoantigenic target in Crohn’s disease patients. It was discussed recently that a long and a short isoform of GP2 exists whereas the short isoform is often detected by GP2-specific autoantibodies. In the outcome of inflammatory bowel diseases, these GP2-specific autoantibodies are discussed as new serological markers for diagnosis and therapeutic monitoring. To investigate this further, camelid nanobodies were generated by phage display and selected against the short isoform of GP2 in order to isolate specific tools for the discrimination of both isoforms. Nanobodies are single domain antibodies derived from camelid heavy chain only antibodies and characterized by a high stability and solubility. The selected candidates were expressed, purified and validated regarding their binding properties in different enzyme-linked immunosorbent assays formats, immunofluorescence, immunohistochemistry and surface plasmon resonance spectroscopy. Four different nanobodies could be selected whereof three recognize the short isoform of GP2 very specifically and one nanobody showed a high binding capacity for both isoforms. The KD values measured for all nanobodies were between 1.3 nM and 2.3 pM indicating highly specific binders suitable for the application as diagnostic tool in inflammatory bowel disease.
Y1  - 2016
SN  - 0022-1767
SN  - 1550-6606
VL  - 196
SP  - 313
EP  - 328
PB  - American Assoc. of Immunologists
CY  - Bethesda
ER  -