TY  - JOUR
A1  - Zou, Hua
A1  - Schlaad, Helmut
T1  - Thermoresponsive PNIPAM/Silica Nanoparticles by Direct Photopolymerization in Aqueous Media
JF  - Journal of polymer science : A, Polymer chemistry
N2  - This article presents a simple and facile method to fabricate thermoresponsive polymer-grafted silica particles by direct surface-initiated photopolymerization of N-isopropylacrylamide (NIPAM). This method is based on silica particles bearing thiol functionalities, which are transformed into thiyl radicals by irradiation with UV light to initiate the polymerization of NIPAM in aqueous media at room temperature. The photopolymerization of NIPAM could be applied to smaller thiol-functionalized particles (approximate to 48 nm) as well as to larger particles (approximate to 692 nm). Hollow poly(NIPAM) capsules could be formed after etching away the silica cores from the composite particles. It is possible to produce tailor-made composite particles or capsules for particular applications by extending this approach to other vinyl monomers. (c) 2015 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 2015, 53, 1260-1267
KW  - nanocomposites
KW  - nanoparticles
KW  - photopolymerization
KW  - silica nanoparticles
KW  - surface-initiated photopolymerization
KW  - thermoresponsive
KW  - thiol
Y1  - 2015
U6  - https://doi.org/10.1002/pola.27593
SN  - 0887-624X
SN  - 1099-0518
VL  - 53
IS  - 10
SP  - 1260
EP  - 1267
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Koshkina, Olga
A1  - Westmeier, Dana
A1  - Lang, Thomas
A1  - Bantz, Christoph
A1  - Hahlbrock, Angelina
A1  - Würth, Christian
A1  - Resch-Genger, Ute
A1  - Braun, Ulrike
A1  - Thiermann, Raphael
A1  - Weise, Christoph
A1  - Eravci, Murat
A1  - Mohr, Benjamin
A1  - Schlaad, Helmut
A1  - Stauber, Roland H.
A1  - Docter, Dominic
A1  - Bertin, Annabelle
A1  - Maskos, Michael
T1  - Tuning the Surface of Nanoparticles: Impact of Poly(2-ethyl-2-oxazoline) on Protein Adsorption in Serum and Cellular Uptake
JF  - Macromolecular bioscience
N2  - Due to the adsorption of biomolecules, the control of the biodistribution of nanoparticles is still one of the major challenges of nanomedicine. Poly(2-ethyl-2-oxazoline) (PEtOx) for surface modification of nanoparticles is applied and both protein adsorption and cellular uptake of PEtOxylated nanoparticles versus nanoparticles coated with poly(ethylene glycol) (PEG) and non-coated positively and negatively charged nanoparticles are compared. Therefore, fluorescent poly(organosiloxane) nanoparticles of 15 nm radius are synthesized, which are used as a scaffold for surface modification in a grafting onto approach. With multi-angle dynamic light scattering, asymmetrical flow field-flow fractionation, gel electrophoresis, and liquid chromatography-mass spectrometry, it is demonstrated that protein adsorption on PEtOxylated nanoparticles is extremely low, similar as on PEGylated nanoparticles. Moreover, quantitative microscopy reveals that PEtOxylation significantly reduces the non-specific cellular uptake, particularly by macrophage-like cells. Collectively, studies demonstrate that PEtOx is a very effective alternative to PEG for stealth modification of the surface of nanoparticles.
KW  - cellular uptake
KW  - nanoparticles
KW  - poly(2-ethyl-2oxazoline)
KW  - poly(ethylene glycol)
KW  - protein adsorption
Y1  - 2016
U6  - https://doi.org/10.1002/mabi.201600074
SN  - 1616-5187
SN  - 1616-5195
VL  - 16
SP  - 1287
EP  - 1300
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Keckeis, Philipp
A1  - Zeller, Enriko
A1  - Jung, Carina
A1  - Besirske, Patricia
A1  - Kirner, Felizitas
A1  - Ruiz-Agudo, Cristina
A1  - Schlaad, Helmut
A1  - Cölfen, Helmut
T1  - Modular toolkit of multifunctional block copoly(2-oxazoline)s for the synthesis of nanoparticles
JF  - Chemistry - a European journal
N2  - Post-polymerization modification provides an elegant way to introduce chemical functionalities onto macromolecules to produce tailor-made materials with superior properties. This concept was adapted to well-defined block copolymers of the poly(2-oxazoline) family and demonstrated the large potential of these macromolecules as universal toolkit for numerous applications. Triblock copolymers with separated water-soluble, alkyne- and alkene-containing segments were synthesized and orthogonally modified with various low-molecular weight functional molecules by copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and thiol-ene (TE) click reactions, respectively. Representative toolkit polymers were used for the synthesis of gold, iron oxide and silica nanoparticles.
KW  - block copolymers
KW  - click chemistry
KW  - nanoparticles
KW  - ring-opening
KW  - polymerization
KW  - surfactants
Y1  - 2021
U6  - https://doi.org/10.1002/chem.202101327
SN  - 0947-6539
SN  - 1521-3765
VL  - 27
IS  - 32
SP  - 8283
EP  - 8287
PB  - Wiley-VCH
CY  - Weinheim
ER  -