TY - JOUR A1 - Uhlemann, Erhard A1 - Friedrich, Alwin A1 - Hinsche, Gerald A1 - Mickler, Wulfhard A1 - Schilde, Uwe T1 - Komplexbildung und Metallextraktion mit heterocyclischen ß-Dicarbonylverbindungen im Vergleich : Struktur von 3-Phenyl-4-benzoyl-isoxazol-5-on Y1 - 1995 ER - TY - JOUR A1 - Uhlemann, Erhard A1 - Ludwig, Eberhard A1 - Hefele, Heike A1 - Schilde, Uwe T1 - Komplexe von Vanadium und Titan mit 2,2'-Dihydroxy-azobenzen : Kristallstrukturen von 2,2'- Dihydroxy-azobenzenato(2-)oxo-methoxo-methanol-vanadium(V) und æ-Oxo-bis[2,2'-dihy droxy-azobenzenato(2-)]-oxo- vanadium(V)] Y1 - 1994 ER - TY - JOUR A1 - Uhlemann, Jacqueline A1 - Duvinage, Brigitte A1 - Schilde, Uwe T1 - Kontexte und Kompetenzen : Komplexverbindungen experimentell erkunden Y1 - 2008 SN - 1617-5638 ER - TY - JOUR A1 - Uhlemann, Erhard A1 - Banße, Wolfgang A1 - Ludwig, Eberhard A1 - Schilde, Uwe A1 - Weller, Frank T1 - Ligand Exchange Reactions of Bis(acetyl-acetonato)dioxomolybdenum(VI) and Molybdenum Hexacarbonyl Y1 - 1995 ER - TY - JOUR A1 - Uhlemann, Erhard A1 - Banße, Wolfgang A1 - Ludwig, Eberhard A1 - Schilde, Uwe A1 - Weller, Frank A1 - Lehmann, Andreas T1 - Ligandenaustauschreaktionen von Bis(acetylacetonato)dioxo-molybdän(VI). Kristallstrukturen von Salicyl- aldehyd-benzoylhydrazonato(2-)]dioxom ethanol-molybdän(VI) und [Benzoylacetonbenzoylhydrazonato(2)]dioxo- triphenylphosphan-oxidmolybdän(VI) Y1 - 1995 ER - TY - JOUR A1 - Schwarze, Thomas A1 - Traeger, Juliane A1 - Kelling, Alexandra A1 - Schilde, Uwe A1 - Holdt, Hans-Jürgen T1 - Macrocyclic dithiomaleonitriles for an efficient PdCl2 coordination JF - Inorganica chimica acta : the international inorganic chemistry journal N2 - We have synthesized a set of new unsaturated macrocyclic dithioethers with an increasing number of flexible methylene units 1-7 (Scheme 2) to investigate the correlation between the ring size of these ligands, the chelation effect and the consequences for an efficient PdCl2 coordination. The dithioethers 1-7 and the complex [PdCl2(4)]center dot CHCl3 were characterized by X-ray diffraction analysis. The crystal structures of 1-7 show that 2-7 are better preorganized chelating ligands for an exocyclic PdCl2 coordination than 1. The chelation effect of 1-7, the orientation of the sulfur atoms and the S center dot center dot center dot S donor distances, are influenced by the flexibility of the methylene units. In this series the unsaturated macrocyclic ligands 5 and 6 are the best chelating ligands for an efficient PdCl2 coordination. Comparative solvent extraction experiments with mn-12S(2)O(2) (mn = maleonitrile) reveal that the low interface activity of the new ligands reduces the extraction rate. However, a comparison with open-chain dithiomaleonitriles shows the impact of the macrocyclic effect of 4 and 5 on the extraction yield. KW - Thioether ligands KW - Palladium KW - Synthesis KW - X-ray diffraction KW - Chelation effect KW - Extraction Y1 - 2013 U6 - https://doi.org/10.1016/j.ica.2013.08.020 SN - 0020-1693 SN - 1873-3255 VL - 408 IS - 2 SP - 53 EP - 58 PB - Elsevier CY - Lausanne ER - TY - JOUR A1 - Gonzalez-Chavarria, Ivan A1 - Duprat, Felix A1 - Roa, Francisco J. A1 - Jara, Nery A1 - Toledo, Jorge R. A1 - Miranda, Felipe A1 - Becerra, Jose A1 - Inostroza, Alejandro A1 - Kelling, Alexandra A1 - Schilde, Uwe A1 - Heydenreich, Matthias A1 - Paz, Cristian T1 - Maytenus disticha extract and an isolated β-Dihydroagarofuran induce mitochondrial depolarization and apoptosis in human cancer cells by increasing mitochondrial reactive oxygen species JF - Biomolecules N2 - Maytenus disticha (Hook F.), belonging to the Celastraceae family, is an evergreen shrub, native of the central southern mountains of Chile. Previous studies demonstrated that the total extract of M. disticha (MD) has an acetylcholinesterase inhibitory activity along with growth regulatory and insecticidal activities. beta-Dihydroagarofurans sesquiterpenes are the most active components in the plant. However, its activity in cancer has not been analyzed yet. Here, we demonstrate that MD has a cytotoxic activity on breast (MCF-7), lung (PC9), and prostate (C4-2B) human cancer cells with an IC50 (mu g/mL) of 40, 4.7, and 5 mu g/mL, respectively, an increasing Bax/Bcl2 ratio, and inducing a mitochondrial membrane depolarization. The beta-dihydroagarofuran-type sesquiterpene (MD-6), dihydromyricetin (MD-9), and dihydromyricetin-3-O-beta-glucoside (MD-10) were isolated as the major compounds from MD extracts. From these compounds, only MD-6 showed cytotoxic activity on MCF-7, PC9, and C4-2B with an IC50 of 31.02, 17.58, and 42.19 mu M, respectively. Furthermore, the MD-6 increases cell ROS generation, and MD and MD-6 induce a mitochondrial superoxide generation and apoptosis on MCF-7, PC9, and C4-2B, which suggests that the cytotoxic effect of MD is mediated in part by the beta-dihydroagarofuran-type that induces apoptosis by a mitochondrial dysfunction. KW - Maytenus disticha KW - beta-dihydroagarofuran-type sesquiterpene KW - dihydromyricetin KW - dihydromyricetin-3-O-beta-glucoside KW - cytotoxic KW - activity KW - Mitochondrial ROS Y1 - 2020 U6 - https://doi.org/10.3390/biom10030377 SN - 2218-273X VL - 10 IS - 3 PB - MDPI CY - Basel ER - TY - JOUR A1 - Holdt, Hans-Jürgen A1 - Müller, Holger A1 - Kelling, Alexandra A1 - Drexler, Hans-Joachim A1 - Müller, Thomas A1 - Schwarze, Thomas A1 - Schilde, Uwe A1 - Starke, Ines T1 - Mercury(II) chloride and iodide complexes of dithia- and tetrathiacrown ethers N2 - The complexes [(HgCl2)(2)((ch)(2)30S(4)O(6))] (1), [HgCl,(mn21S(2)O(5))] (2), [HgCl2(ch18S(2)O(4))] (3) and [HgI(meb12S(2)O(2))](2)[Hg2I6] (4) have been synthesized, characterized and their crystal structures were determined. In [(HgCl2)(2)((ch)(2)3OS(4)O(6))] two HgCl2 units are discretely bonded within the ligand cavity of the 30-membered dichinoxaline-tetrathia-30-crown-10 ((ch)(2)30S(4)O(6)) forming a binuclear complex. HgCl2 forms I : I "in-cavity" complexes with the 21-membered maleonitrile-dithia-21-crown-7(mn21S(2)O(5)) ligand and the 18-membered chinoxaline- dithia-18-crown-6 (ch18S(2)O(4)) ligand, respectively. The 12-membered 4-methyl-benzo-dithia-12-crown-4 (meb12S(2)O(2)) ligand gave with two equivalents HgI2 the compound [HgI(meb12S(2)O(2))](2)[Hg2I6]. In the cation [HgI(meb12S(2)O(2))](+) meb12S(2)O(2) forms with the cation HgI+ a half-sandwich complex Y1 - 2006 UR - http://www3.interscience.wiley.com/cgi-bin/jhome/10005159 U6 - https://doi.org/10.1002/zaac.200500281 SN - 0044-2313 ER - TY - JOUR A1 - Sardarian, Ali Reza A1 - Inaloo, Iman Dindarloo A1 - Modarresi-Alam, Ali Reza A1 - Kleinpeter, Erich A1 - Schilde, Uwe T1 - Metal-Free Regioselective Monocyanation of Hydroxy-, Alkoxy-, and Benzyloxyarenes by Potassium Thiocyanate and Silica Sulfuric Acid as a Cyanating Agent JF - The journal of organic chemistry N2 - A novel and efficient metal- and solvent-free regioselective para-C-H cyanation of hydroxy-, alkoxy-, and benzyloxyarene derivatives has been introduced, using nontoxic potassium thiocyanate as a cyanating reagent in the presence of silica sulfuric acid (SSA). The desired products are obtained in good to high yields without any toxic byproducts. Y1 - 2019 U6 - https://doi.org/10.1021/acs.joc.8b02191 SN - 0022-3263 VL - 84 IS - 4 SP - 1748 EP - 1756 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Wessig, Pablo A1 - Gerngross, Maik A1 - Freyse, Daniel A1 - Bruhn, P. A1 - Przezdziak, Marc A1 - Schilde, Uwe A1 - Kelling, Alexandra T1 - Molecular Rods Based on Oligo-spiro-thioketals JF - The journal of organic chemistry N2 - We report on an extension of the previously established concept of oligospiroketal (OSK) rods by replacing a part or all ketal moieties by thioketals leading to oligospirothioketal (OSTK) rods. In this way, some crucial problems arising from the reversible formation of ketals are circumvented. Furthermore, the stability of the rods toward hydrolysis is considerably improved. To successfully implement this concept, we first developed a number of new oligothiol building blocks and improved the synthetic accessibility of known oligothiols, respectively. Another advantage of thioacetals is that terephthalaldehyde (TAA) sleeves, which are too flexible in the case of acetals can be used in OSTK rods. The viability of the OSTK approach was demonstrated by the successful preparation of some OSTK rods with a length of some nanometers. Y1 - 2016 U6 - https://doi.org/10.1021/acs.joc.5b02670 SN - 0022-3263 VL - 81 SP - 1125 EP - 1136 PB - American Chemical Society CY - Washington ER -