TY  - JOUR
A1  - Rumschöttel, Jens
A1  - Baus, Susann
A1  - Kosmella, Sabine
A1  - Appelhans, Dietmar
A1  - Koetz, Joachim
T1  - Incorporation of DNA/PEI polyplexes into gelatin/chitosan hydrogel scaffolds
BT  - a mu-DSC study
JF  - Composite interfaces
N2  - Polyplexes between a double-stranded Salmon DNA and hyperbranched poly(ethyleneimine) (PEI) as well as a maltosylated PEI-Mal were incorporated into a gelatin/chitosan hydrogel scaffold. Calorimetric experiments of the polyplexes show a decrease of the melting temperature in presence of PEI and a peak splitting in presence of PEI-Mal, which can be interpreted to a partial compaction of the DNA strands in presence of PEI-Mal. When the polyplexes are incorporated into a gelatin/chitosan scaffold in the swollen state, the DNA melting peaks at 90 and 93 degrees C, respectively, indicate in both cases the release of the DNA at the surface of the hydrogel scaffold in a more compact form. Specific interactions between the PEI-Mal shell and gelatin are responsible for the tuning of the release properties in presence of the maltose units in the hyperbranched PEI.
KW  - DNA-PEI polyplexes
KW  - maltosylated poly(ethyleneimine)
KW  - mu-DSC
KW  - DNA release
KW  - gelatin/chitosan hydrogel scaffold
Y1  - 2017
U6  - https://doi.org/10.1080/09276440.2017.1302725
SN  - 1568-5543
VL  - 25
IS  - 1
SP  - 1
EP  - 11
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon
ER  -