TY  - GEN
A1  - Ferenz, Hans-Jürgen
A1  - Peter, Martin G.
A1  - Berg, Dieter
T1  - Inhibition of farnesoic acid methyltransferase by sinefungin
N2  - Sinefungin inhibited the S-adenosylmethionine-dependent farnesoic acid methyltransferase in a cell-free system containing a homogenate of corpora allata from female locusts, Locusta migratoria. The enzyme catalyzed the penultimate step of juvenile hormone biosynthesis in the insects. Culturing corpora allata in the presence of sinefungin greatly suppressed juvenile hormone production. The following in vivo effects were visible after injection of the inhibitor: increase in mortality and reduction of total haemolymph protein liter and ovary fresh weight, as well as length of terminal oocytes. Attempts to reverse these effects by topical application of the juvenile hormone analog ZR-515 (methoprene) were only partly successful. Therefore, the in vivo effects may be due to a general inhibition of methyltransferase enzymes in the insect. Sinefungin appeared to be of potential interest as the first representative of a new class of insect growth regulators.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 077 
KW  - Juvenile hormone analogue
KW  - Orthoptera
KW  - Juvenile hormone
KW  - Biosynthesis
KW  - Enzyme
KW  - Corpora allata
KW  - In vitro
KW  - Biological activity
KW  - Enzyme inhibitor
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-17016
ER  -