TY  - JOUR
A1  - Finke, Hannah
A1  - Winkelbeiner, Nicola Lisa
A1  - Lossow, Kristina
A1  - Hertel, Barbara
A1  - Wandt, Viktoria Klara Veronika
A1  - Schwarz, Maria
A1  - Pohl, Gabriele
A1  - Kopp, Johannes Florian
A1  - Ebert, Franziska
A1  - Kipp, Anna Patricia
A1  - Schwerdtle, Tanja
T1  - Effects of a Cumulative, Suboptimal Supply of Multiple Trace Elements in Mice
BT  - trace element status, genomic stability, inflammation, and epigenetics
JF  - Molecular nutrition & food research
N2  - Scope: Trace element (TE) deficiencies often occur accumulated, as nutritional intake is inadequate for several TEs, concurrently. Therefore, the impact of a suboptimal supply of iron, zinc, copper, iodine, and selenium on the TE status, health parameters, epigenetics, and genomic stability in mice are studied. Methods and results: Male mice receive reduced or adequate amounts of TEs for 9 weeks. The TE status is analyzed mass‐spectrometrically in serum and different tissues. Furthermore, gene and protein expression of TE biomarkers are assessed with focus on liver. Iron concentrations are most sensitive toward a reduced supply indicated by increased serum transferrin levels and altered hepatic expression of iron‐related genes. Reduced TE supply results in smaller weight gain but higher spleen and heart weights. Additionally, inflammatory mediators in serum and liver are increased together with hepatic genomic instability. However, global DNA (hydroxy)methylation is unaffected by the TE modulation. Conclusion: Despite homeostatic regulation of most TEs in response to a low intake, this condition still has substantial effects on health parameters. It appears that the liver and immune system react particularly sensitive toward changes in TE intake. The reduced Fe status might be the primary driver for the observed effects.
Y1  - 2020
U6  - https://doi.org/10.1002/mnfr.202000325
SN  - 1613-4125
VL  - 64
IS  - 16
PB  - Wiley-VCH
CY  - Weinheim
ER  -