TY  - JOUR
A1  - Omole, Ruth Anyango
A1  - Moshi, Mainen Julius
A1  - Heydenreich, Matthias
A1  - Malebo, Hamisi Masanja
A1  - Gathirwa, Jeremiah Waweru
A1  - Ochieng, Sharon Alice
A1  - Omosa, Leonida Kerubo
A1  - Midiwo, Jacob Ogweno
T1  - Two lignans derivatives and two fusicoccane diterpenoids from the whole plant of Hypoestes verticillaris (L.F.) Sol. Ex roem. & schult
JF  - Phytochemistry letters
N2  - Bioassay-guided screening of Hypoestes verticillaris whole plant CH2Cl2: MeOH (1:1) extract for anti-plasmodial activity yielded four new compounds: two lignans 2, 6-dimethoxysavinin (1), 2,6-dimethoxy-(7E)-7,8-dehydroheliobuphthalmin (2); and two fusicoccane diterpenoids: 11(12)-epoxyhypoestenone (3) and 3(11)-epoxyhypoestenone (4). The chemical structures were determined using various spectroscopic techniques: UV-vis, IR, CD, 1D, 2D and MS. Two fractions (RAO-43B and RAO-43D) and the isolated compounds were tested for activity against CQ susceptible (D6) and resistant (W2) Plasmodium falciparum parasite strains, in vitro and the IC50 values determined. While the whole extract and some resultant fractions displayed moderate activity, the isolated compounds exhibited mild anti-plasmodial activity against the both strains ranging from IC50 value of 328 mu M in 1 to 93 mu M in 3 against W2 strain.
KW  - Fusicoccane diterpenes
KW  - Lignans
KW  - Hypoestes verticillaris
KW  - Anti-Plasmodial activity
Y1  - 2019
U6  - https://doi.org/10.1016/j.phytol.2019.02.019
SN  - 1874-3900
SN  - 1876-7486
VL  - 30
SP  - 194
EP  - 200
PB  - Elsevier
CY  - Amsterdam
ER  -