TY  - JOUR
A1  - Duydu, Yalcin
A1  - Basaran, Nursen
A1  - Aydin, Sevtap
A1  - Ustundag, Aylin
A1  - Yalcin, Can Özgür
A1  - Anlar, Hatice Gul
A1  - Bacanli, Merve
A1  - Aydos, Kaan
A1  - Atabekoglu, Cem Somer
A1  - Golka, Klaus
A1  - Ickstadt, Katja
A1  - Schwerdtle, Tanja
A1  - Werner, Matthias
A1  - Meyer, Sören
A1  - Bolt, Hermann M.
T1  - Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions
JF  - Archives of toxicology : official journal of EUROTOX
N2  - Boric acid and sodium borates are currently classified in the EU-CLP regulation as "toxic to reproduction" under "Category 1B", with hazard statement of H360FD. However, so far field studies on male reproduction in China and in Turkey could not confirm such boron-associated toxic effects. As validation by another independent study is still required, the present study has investigated possible boron-associated effects on male reproduction in workers (n = 212) under different boron exposure conditions. The mean daily boron exposure (DBE) and blood boron concentration of workers in the extreme exposure group (n = 98) were 47.17 +/- 17.47 (7.95-106.8) mg B/day and 570.6 +/- 160.1 (402.6-1100) ng B/g blood, respectively. Nevertheless, boron-associated adverse effects on semen parameters, as well as on FSH, LH and total testosterone levels were not seen, even within the extreme exposure group. With this study, a total body of evidence has accumulated that allows to conclude that male reproductive effects are not relevant to humans, under any feasible and realistic conditions of exposure to inorganic boron compounds.
KW  - Boron exposure
KW  - Boric acid
KW  - Reproductive toxicity
KW  - FSH
KW  - LH
KW  - Testosterone
KW  - Semen parameters
Y1  - 2018
U6  - https://doi.org/10.1007/s00204-018-2296-7
SN  - 0340-5761
SN  - 1432-0738
VL  - 92
IS  - 10
SP  - 3051
EP  - 3059
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - GEN
A1  - Meyer, Sören
A1  - Schulz, Jacqueline
A1  - Jeibmann, Astrid
A1  - Taleshi, Mojtaba S.
A1  - Ebert, Franziska
A1  - Francesconi, Kevin
A1  - Schwerdtle, Tanja
T1  - Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster
N2  - Arsenic-containing hydrocarbons (AsHC) constitute one group of arsenolipids that have been identified in seafood. In this first in vivo toxicity study for AsHCs, we show that AsHCs exert toxic effects in Drosophila melanogaster in a concentration range similar to that of arsenite. In contrast to arsenite, however, AsHCs cause developmental toxicity in the late developmental stages of Drosophila melanogaster. This work illustrates the need for a full characterisation of the toxicity of AsHCs in experimental animals to finally assess the risk to human health related to the presence of arsenolipids in seafood.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 183 
KW  - cod-liver
KW  - arsenolipids present
KW  - fatty-acids
KW  - rp-hplc
KW  - identification
KW  - fish
KW  - oil
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-76819
VL  - 11
IS  - 6
SP  - 2010
EP  - 2014
ER  - 
TY  - JOUR
A1  - Meyer, Sören
A1  - Schulz, Jacqueline
A1  - Jeibmann, Astrid
A1  - Taleshi, Mojtaba S.
A1  - Ebert, Franziska
A1  - Francesconi, Kevin
A1  - Schwerdtle, Tanja
ED  - Schwerdtle, Tanja
T1  - Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster
JF  - Metallomics
N2  - Arsenic-containing hydrocarbons (AsHC) constitute one group of arsenolipids that have been identified in seafood. In this first in vivo toxicity study for AsHCs, we show that AsHCs exert toxic effects in Drosophila melanogaster in a concentration range similar to that of arsenite. In contrast to arsenite, however, AsHCs cause developmental toxicity in the late developmental stages of Drosophila melanogaster. This work illustrates the need for a full characterisation of the toxicity of AsHCs in experimental animals to finally assess the risk to human health related to the presence of arsenolipids in seafood.
KW  - arsenolipids present
KW  - cod-liver
KW  - fatty-acids
KW  - identification
KW  - rp-hplc
KW  - fish
KW  - oil
Y1  - 2014
SN  - 1756-5901
SP  - 2010
EP  - 2014
PB  - The Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - GEN
A1  - Meyer, Sören
A1  - Matissek, M.
A1  - Müller, Sandra Marie
A1  - Taleshi, M. S.
A1  - Ebert, Franziska
A1  - Francesconi, Kevin A.
A1  - Schwerdtle, Tanja
T1  - In vitro toxicological characterisation of three arsenic-containing hydrocarbons
N2  - Arsenic-containing hydrocarbons are one group of fat-soluble organic arsenic compounds (arsenolipids) found in marine fish and other seafood. A risk assessment of arsenolipids is urgently needed, but has not been possible because of the total lack of toxicological data. In this study the cellular toxicity of three arsenic-containing hydrocarbons was investigated in cultured human bladder (UROtsa) and liver (HepG2) cells. Cytotoxicity of the arsenic-containing hydrocarbons was comparable to that of arsenite, which was applied as the toxic reference arsenical. A large cellular accumulation of arsenic, as measured by ICP-MS/MS, was observed after incubation of both cell lines with the arsenolipids. Moreover, the toxic mode of action shown by the three arsenic-containing hydrocarbons seemed to differ from that observed for arsenite. Evidence suggests that the high cytotoxic potential of the lipophilic arsenicals results from a decrease in the cellular energy level. This first in vitro based risk assessment cannot exclude a risk to human health related to the presence of arsenolipids in seafood, and indicates the urgent need for further toxicity studies in experimental animals to fully assess this possible risk.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 170 
KW  - cod-liver
KW  - human-cells
KW  - arsenolipids present
KW  - excision-repair
KW  - fatty-acids
KW  - marine oils
KW  - RP-HPLC
KW  - metabolites
KW  - identification
KW  - trivalent
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-74201
SP  - 1023
EP  - 1033
ER  - 
TY  - JOUR
A1  - Meyer, Sören
A1  - Matissek, M.
A1  - Müller, Sandra Marie
A1  - Taleshi, M. S.
A1  - Ebert, Franziska
A1  - Francesconi, Kevin A.
A1  - Schwerdtle, Tanja
T1  - In vitro toxicological characterisation of three arsenic-containing hydrocarbons
JF  - Metallomics
N2  - Arsenic-containing hydrocarbons are one group of fat-soluble organic arsenic compounds (arsenolipids) found in marine fish and other seafood. A risk assessment of arsenolipids is urgently needed, but has not been possible because of the total lack of toxicological data. In this study the cellular toxicity of three arsenic-containing hydrocarbons was investigated in cultured human bladder (UROtsa) and liver (HepG2) cells. Cytotoxicity of the arsenic-containing hydrocarbons was comparable to that of arsenite, which was applied as the toxic reference arsenical. A large cellular accumulation of arsenic, as measured by ICP-MS/MS, was observed after incubation of both cell lines with the arsenolipids. Moreover, the toxic mode of action shown by the three arsenic-containing hydrocarbons seemed to differ from that observed for arsenite. Evidence suggests that the high cytotoxic potential of the lipophilic arsenicals results from a decrease in the cellular energy level. This first in vitro based risk assessment cannot exclude a risk to human health related to the presence of arsenolipids in seafood, and indicates the urgent need for further toxicity studies in experimental animals to fully assess this possible risk.
KW  - cod-liver
KW  - human-cells
KW  - arsenolipids present
KW  - excision-repair
KW  - fatty-acids
KW  - marine oils
KW  - RP-HPLC
KW  - metabolites
KW  - identification
KW  - trivalent
Y1  - 2014
U6  - https://doi.org/10.1039/c4mt00061g
SN  - 1756-591X
SN  - 1756-5901
VL  - 2014
IS  - 6
SP  - 1023
EP  - 1033
ER  -