TY  - JOUR
A1  - Omole, Ruth Anyango
A1  - Moshi, Mainen Julius
A1  - Heydenreich, Matthias
A1  - Malebo, Hamisi Masanja
A1  - Gathirwa, Jeremiah Waweru
A1  - Ochieng, Sharon Alice
A1  - Omosa, Leonida Kerubo
A1  - Midiwo, Jacob Ogweno
T1  - Two lignans derivatives and two fusicoccane diterpenoids from the whole plant of Hypoestes verticillaris (L.F.) Sol. Ex roem. & schult
JF  - Phytochemistry letters
N2  - Bioassay-guided screening of Hypoestes verticillaris whole plant CH2Cl2: MeOH (1:1) extract for anti-plasmodial activity yielded four new compounds: two lignans 2, 6-dimethoxysavinin (1), 2,6-dimethoxy-(7E)-7,8-dehydroheliobuphthalmin (2); and two fusicoccane diterpenoids: 11(12)-epoxyhypoestenone (3) and 3(11)-epoxyhypoestenone (4). The chemical structures were determined using various spectroscopic techniques: UV-vis, IR, CD, 1D, 2D and MS. Two fractions (RAO-43B and RAO-43D) and the isolated compounds were tested for activity against CQ susceptible (D6) and resistant (W2) Plasmodium falciparum parasite strains, in vitro and the IC50 values determined. While the whole extract and some resultant fractions displayed moderate activity, the isolated compounds exhibited mild anti-plasmodial activity against the both strains ranging from IC50 value of 328 mu M in 1 to 93 mu M in 3 against W2 strain.
KW  - Fusicoccane diterpenes
KW  - Lignans
KW  - Hypoestes verticillaris
KW  - Anti-Plasmodial activity
Y1  - 2019
U6  - https://doi.org/10.1016/j.phytol.2019.02.019
SN  - 1874-3900
SN  - 1876-7486
VL  - 30
SP  - 194
EP  - 200
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kerubo, Leonidah Omosa
A1  - Midiwo, Jacob Ogweno
A1  - Derese, Solomon
A1  - Langat, Moses K.
A1  - Akala, Hoseah M.
A1  - Waters, Norman C.
A1  - Peter, Martin
A1  - Heydenreich, Matthias
T1  - Antiplasmodial activity of compounds from the surface exudates of senecio roseiflorus
JF  - Natural product communications : an international journal for communications and reviews
N2  - From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 mu g/mL respectively.
KW  - Senecio roseiflorus
KW  - Asteraceae
KW  - Surface exudates
KW  - Antiplasmodial activity
Y1  - 2013
SN  - 1934-578X
VL  - 8
IS  - 2
SP  - 175
EP  - 176
PB  - NPC
CY  - Westerville
ER  -