TY  - JOUR
A1  - Chea, Sany
A1  - Schade, Kristin
A1  - Reinicke, Stefan
A1  - Bleul, Regina
A1  - Rosencrantz, Ruben R.
T1  - Synthesis and self-assembly of cytidine- and guanosine-based copolymers
JF  - Polymer Chemistry
N2  - The base pairing property and the "melting" behavior of oligonucleotides can take advantage to develop new smart thermoresponsive and programmable materials. Complementary cytidine- (C) and guanosine- (G) based monomers were blockcopolymerized using RAFT polymerization technique with poly-(N-(2-hydroxypropyl) methacrylamide) (pHPMA) as the hydrophilic macro chain transfer agent (macro-CTA). C-C, G-G and C-G hydrogen bond interactions of blockcopolymers with respectively C and G moieties have been investigated using SEM, DLS and UV-Vis. Mixing and heating both complementary copolymers resulted in reforming new aggregates. Due to the ribose moiety of the isolated nucleoside-bearing blockcopolymers, the polarity is increased for better solubility. Self-assembly investigations of these bioinspired compounds are the crucial basis for the development of potential future drug delivery systems.
Y1  - 2022
U6  - https://doi.org/10.1039/d2py00615d
SN  - 1759-9954
SN  - 1759-9962
VL  - 13
IS  - 35
SP  - 5058
EP  - 5067
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  -