TY  - JOUR
A1  - Brunacci, Nadia
A1  - Wischke, Christian
A1  - Naolou, Toufik
A1  - Neffe, Axel T.
A1  - Lendlein, Andreas
T1  - Influence of surfactants on depsipeptide submicron particle formation
JF  - European Journal of Pharmaceutics and Biopharmaceutics
N2  - Surfactants are required for the formation and stabilization of hydrophobic polymeric particles in aqueous environment. In order to form submicron particles of varying sizes from oligo[3-(S)-sec-butylmorpholine-2,5-dione]diols ((OBMD)-diol), different surfactants were investigated. As new surfactants, four-armed star-shaped oligo(ethylene glycol)s of molecular weights of 5-20 kDa functionalized with desamino-tyrosine (sOEG-DAT) resulted in smaller particles with lower PDI than with desaminotyrosyl tyrosine (sOEG-DATT) in an emulsion/solvent evaporation method. In a second set of experiments, sOEG-DAT of M-n= 10 kDa was compared with the commonly employed emulsifiers polyvinylalcohol (PVA), polyoxyethylene (20) sorbitan monolaurate (Tween 20), and D-alpha-tocopherol polyethylene glycol succinate (VIT E-TPGS) for OBMD particle preparation. sOEG-DAT allowed to systematically change sizes in a range of 300 up to 900 nm with narrow polydispersity, while in the other cases, a lower size range (250-400 nm, PVA; 300 nm, Tween 20) or no effective particle formation was observed. The ability of tailoring particle size in a broad range makes sOEG-DAT of particular interest for the formation of oligodepsipeptide particles, which can further be investigated as drug carriers for controlled delivery. (C) 2016 Elsevier B.V. All rights reserved.
KW  - Depsipeptide
KW  - Particle size
KW  - Surfactants
KW  - Submicron particles
Y1  - 2017
U6  - https://doi.org/10.1016/j.ejpb.2016.11.011
SN  - 0939-6411
SN  - 1873-3441
VL  - 116
SP  - 61
EP  - 65
PB  - Elsevier
CY  - Amsterdam
ER  -