TY  - JOUR
A1  - Karuwanarint, Piyaporn
A1  - Phonrat, Benjaluck
A1  - Tungtrongchitr, Anchalee
A1  - Suriyaprom, Kanjana
A1  - Chuengsamarn, Somlak
A1  - Schweigert, Florian J.
A1  - Tungtrongchitr, Rungsunn
T1  - Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome
JF  - Biomarkers in medicine
N2  - Aim: To investigate the relationship of vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. Materials & methods: GCglobulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. Results: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found. Male participants who carried the GT genotype for rs4588 showed an increased risk of MetS compared with the GG wild-type (odds ratio: 3.25; p = 0.004). Conclusion: GC-globulin concentrations and variation in GC rs4588 were supported as a risk factor for MetS in Thais.
KW  - GC gene
KW  - GC-globulin
KW  - metabolic syndrome
KW  - polymorphism
KW  - Thai population
KW  - vitamin D-binding protein
Y1  - 2018
U6  - https://doi.org/10.2217/bmm-2018-0029
SN  - 1752-0363
SN  - 1752-0371
VL  - 12
IS  - 5
SP  - 465
EP  - 473
PB  - Future Medicine
CY  - London
ER  - 
TY  - CHAP
A1  - Funkeu, A. D. M.
A1  - Gouado, I.
A1  - Schweigert, Florian J.
A1  - Tchounguep, F.
T1  - Serum response to a single dose of dietary carotenoids from steamed, fried and steam-dried squashes pulp (Cucurbita spp)
T2  - Annals of nutrition & metabolism : journal of nutrition, metabolic diseases and dietetics ; an official journal of International Union of Nutritional Sciences (IUNS)
KW  - Squashes pulp
KW  - steamed
KW  - fried
KW  - steam-dried
KW  - carotenoids bioavailability
Y1  - 2013
SN  - 0250-6807
SN  - 1421-9697
VL  - 63
IS  - 3
SP  - 1501
EP  - 1501
PB  - Karger
CY  - Basel
ER  - 
TY  - JOUR
A1  - Henze, Andrea
A1  - Raila, Jens
A1  - Scholze, Alexandra
A1  - Zidek, Walter
A1  - Tepel, Martin
A1  - Schweigert, Florian J.
T1  - Does N-Acetylcysteine modulate post-translational modifications of transthyretin in hemodialysis patients?
JF  - Antioxidants & redox signaling
N2  - It is assumed that effects of the thiol antioxidant N-acetylcysteine (NAC) are mediated by interaction with protein-associated cysteine residues, however, information on protein level in vivo are missing. Therefore, we analyzed NAC-induced modifications of the protein transthyretin (TTR) in plasma of hemodialysis patients in a randomized, placebo-controlled study. TTR was selected due to its low molecular weight and the free cysteine residue in the polypeptide chain, which is known to be extensively modified by formation of mixed disulfides. The intravenous application of NAC during a hemodialysis session resulted in a substantial increase of native TTR from median 15% (range 8.8%-30%) to median 40% (37-50) and reduction of S-cysteinylated TTR [51% (44-60) vs. 6.6% (2.4-10)]. Additionally the pronounced formation of a TTR-NAC adduct was detected. However, all these modifications seemed to be reversible. Additionally, in vitro incubation of plasma with NAC confirmed the in vivo results and indicated that changes in post-translational modification pattern of TTR were a function of NAC concentration. Based on these observations and the essential metabolic and biochemical role of protein-associated cysteine residues we hypothesize that the interaction of NAC with proteins may explain altered protein functions due to modification of cysteine residues. Antioxid. Redox Signal. 19, 1166-1172.
Y1  - 2013
U6  - https://doi.org/10.1089/ars.2012.5125
SN  - 1523-0864
VL  - 19
IS  - 11
SP  - 1166
EP  - 1172
PB  - Liebert
CY  - New Rochelle
ER  - 
TY  - CHAP
A1  - Schweigert, Florian J.
A1  - Raila, Jens
A1  - Mothes, Ralf
A1  - Frey, S.
T1  - Point of care measurements of Vitamin A in blood and breast milk for low resource settings
T2  - Annals of nutrition & metabolism : journal of nutrition, metabolic diseases and dietetics ; an official journal of International Union of Nutritional Sciences (IUNS)
KW  - Blood
KW  - Milk
KW  - Point of Care Assay and Vitamin A
Y1  - 2011
SN  - 0250-6807
VL  - 58
IS  - 2
SP  - 382
EP  - 382
PB  - Karger
CY  - Basel
ER  -