TY  - JOUR
A1  - Adem, Fozia A.
A1  - Kuete, Victor
A1  - Mbaveng, Armelle T.
A1  - Heydenreich, Matthias
A1  - Koch, Andreas
A1  - Ndakala, Albert
A1  - Irungu, Beatrice
A1  - Yenesew, Abiy
A1  - Efferth, Thomas
T1  - Cytotoxic flavonoids from two Lonchocarpus species
JF  - Natural Product Research
N2  - A new isoflavone, 4′-prenyloxyvigvexin A (1) and a new pterocarpan, (6aR,11aR)-3,8-dimethoxybitucarpin B (2) were isolated from the leaves of Lonchocarpus bussei and the stem bark of Lonchocarpus eriocalyx, respectively. The extract of L. bussei also gave four known isoflavones, maximaisoflavone H, 7,2′-dimethoxy-3′,4′-methylenedioxyisoflavone, 6,7,3′-trimethoxy-4′,5′-methylenedioxyisoflavone, durmillone; a chalcone, 4-hydroxylonchocarpin; a geranylated phenylpropanol, colenemol; and two known pterocarpans, (6aR,11aR)-maackiain and (6aR,11aR)-edunol. (6aR,11aR)-Edunol was also isolated from the stem bark of L. eriocalyx. The structures of the isolated compounds were elucidated by spectroscopy. The cytotoxicity of the compounds was tested by resazurin assay using drug-sensitive and multidrug-resistant cancer cell lines. Significant antiproliferative effects with IC50 values below 10 μM were observed for the isoflavones 6,7,3′-trimethoxy-4′,5′-methylenedioxyisoflavone and durmillone against leukemia CCRF-CEM cells; for the chalcone, 4-hydroxylonchocarpin and durmillone against its resistant counterpart CEM/ADR5000 cells; as well as for durmillone against the resistant breast adenocarcinoma MDA-MB231/BCRP cells and resistant gliobastoma U87MG.ΔEGFR cells.
KW  - Lonchocarpus bussei
KW  - Lonchocarpus eriocalyx
KW  - Leguminosae
KW  - isoflavone
KW  - pterocarpan
KW  - cytotoxicity
Y1  - 2019
U6  - https://doi.org/10.1080/14786419.2018.1462179
SN  - 1478-6419
SN  - 1478-6427
VL  - 33
IS  - 18
SP  - 2609
EP  - 2617
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon
ER  -