TY  - JOUR
A1  - Hohmann, Sarah
A1  - Hohm, Erika
A1  - Treutlein, Jens
A1  - Blomeyer, Dorothea
A1  - Jennen-Steinmetz, Christine
A1  - Schmidt, Martin H.
A1  - Esser, Günter
A1  - Banaschewski, Tobias
A1  - Brandeis, Daniel
A1  - Laucht, Manfred
T1  - Association of norepinephrine transporter (NET, SLC6A2) genotype with ADHD-related phenotypes: Findings of a longitudinal study from birth to adolescence
JF  - Psychiatry research : the official publication of the International Society for Neuroimaging in Psychiatry
N2  - Variation in the gene encoding for the norepinephrine transporter (NET, SLC6A2) has repeatedly been linked with ADHD, although there is some inconsistency regarding the association with specific genes. The variants for which most consistent association has been found are the NET variants rs3785157 and rs28386840. Here, we tested for their association with ADHD diagnosis and ADHD-related phenotypes during development in a longitudinal German community sample. Children were followed from age 4 to age 15, using diagnostic interviews to assess ADHD. Between the ages of 8 and 15 years, the Child Behavior Checklist (CBCL) was administered to the primary caregivers. The continuous performance task (CPT) was performed at age 15. Controlling for possible confounders, we found that homozygous carriers of the major A allele of the functional promoter variant rs28386840 displayed a higher rate of ADHD lifetime diagnosis. Moreover, homozygous carriers of the minor T allele of rs3785157 were more likely to develop ADHD and showed higher scores on the CBCL externalizing behavior scales. Additionally, we found that individuals heterozygous for rs3785157 made fewer omission errors in the CPT than homozygotes. This is the first longitudinal study to report associations between specific NET variants and ADHD-related phenotypes during the course of development. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
KW  - Attention-deficit/hyperactivity disorder
KW  - Norepinephrine transporter
KW  - Genetic association
KW  - Polymorphism
KW  - Molecular heterosis
KW  - Continuous performance task
Y1  - 2015
U6  - https://doi.org/10.1016/j.psychres.2014.12.029
SN  - 0165-1781
VL  - 226
IS  - 2-3
SP  - 425
EP  - 433
PB  - Elsevier
CY  - Clare
ER  -