TY  - JOUR
A1  - Eichler, Hans Joachim
A1  - Haase, Alfred
A1  - Menzel, Ralf
A1  - Schwartz, J.
T1  - Depolarization treatment and optimization of high power double pass neodym-rod amplifiers with SBS mirror
Y1  - 1994
ER  - 
TY  - JOUR
A1  - Eichler, Hans Joachim
A1  - Haase, Alfred
A1  - Menzel, Ralf
T1  - SBS-Phase Conjugation for Thermal Lens Compensation in 100 Watt Average Power Solid-State Lasers
Y1  - 1994
ER  - 
TY  - JOUR
A1  - Eichler, Hans Joachim
A1  - Haase, Alfred
A1  - Menzel, Ralf
T1  - 100 watt average output power 1.2*diffraction limited beam from pulsed neodym single rod amplifier with SBS- phaseconjugation
BT  - Onehundred watt average output 1.2*diffraction limited beam from pulsed neodym single rod amplifier with SBS- phaseconjugation
T2  - Hundred watt average output power 1.2*diffraction limited beam from pulsed neodym single rod amplfier with SBS- phaseconjugation
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Eichler, Hans Joachim
A1  - Haase, Alfred
A1  - Menzel, Ralf
T1  - Power enhancement and application of a Nd:YALO rod amplifier with a phase conjugating mirror
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Eichler, Hans Joachim
A1  - Haase, Alfred
A1  - Menzel, Ralf
T1  - Power enhancement and application of a Nd:YALO rod amplifier with a phase conjugating mirror
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Menzel, Ralf
A1  - Eichler, Hans Joachim
A1  - Geinitz, E.
A1  - Haase, Alfred
A1  - Scherrer, R.
T1  - Neodymium-laser with SBS phase conjugation for high beam quality
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Eichler, Hans Joachim
A1  - Haase, Alfred
A1  - Menzel, Ralf
T1  - High beam quality of a single rod neodym amplifier by SBS-phase conjugation up to 140 watt average output
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Draude, F.
A1  - Galla, S.
A1  - Pelster, Axel
A1  - Tentschert, J.
A1  - Jungnickel, H.
A1  - Haase, Alfred
A1  - Mantion, Alexandre
A1  - Thuenemann, Andreas F.
A1  - Taubert, Andreas
A1  - Luch, A.
A1  - Arlinghaus, H. F.
T1  - ToF-SIMS and Laser-SNMS analysis of macrophages after exposure to silver nanoparticles
JF  - Surface and interface analysis : an international journal devoted to the development and application of techniques for the analysis surfaces, interfaces and thin films
N2  - Silver nanoparticles (SNPs) are among the most commercialized nanoparticles because of their antibacterial effects. Besides being employed, e. g. as a coatingmaterial for sterile surfaces in household articles and appliances, the particles are also used in a broad range of medical applications. Their antibacterial properties make SNPs especially useful for wound disinfection or as a coating material for prostheses and surgical instruments. Because of their optical characteristics, the particles are of increasing interest in biodetection as well. Despite the widespread use of SNPs, there is little knowledge of their toxicity. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) and laser post-ionization secondary neutral mass spectrometry (Laser-SNMS) were used to investigate the effects of SNPs on human macrophages derived from THP-1 cells in vitro. For this purpose, macrophages were exposed to SNPs. The SNP concentration ranges were chosen with regard to functional impairments of the macrophages. To optimize the analysis of the macrophages, a special silicon wafer sandwich preparation technique was employed; ToF-SIMS was employed to characterize fragments originating from macrophage cell membranes. With the use of this optimized sample preparation method, the SNP-exposed macrophages were analyzed with ToF-SIMS and with Laser-SNMS. With Laser-SNMS, the three-dimensional distribution of SNPs in cells could be readily detected with very high efficiency, sensitivity, and submicron lateral resolution. We found an accumulation of SNPs directly beneath the cell membrane in a nanoparticular state as well as agglomerations of SNPs inside the cells.
KW  - Laser-SNMS
KW  - ToF-SIMS
KW  - life sciences
KW  - imaging
KW  - nanoparticles
KW  - three-dimensional depth profiling
Y1  - 2013
U6  - https://doi.org/10.1002/sia.4902
SN  - 0142-2421
VL  - 45
IS  - 1
SP  - 286
EP  - 289
PB  - Wiley-Blackwell
CY  - Hoboken
ER  -