TY  - JOUR
A1  - Batsios, Petros
A1  - Peter, Tatjana
A1  - Baumann, Otto
A1  - Stick, Reimer
A1  - Meyer, Irene
A1  - Gräf, Ralph
T1  - A lamin in lower eukaryotes?
JF  - Nucleus
N2  - Lamins are the major components of the nuclear lamina and serve not only as a mechanical support, but are also involved in chromatin organization, epigenetic regulation, transcription and mitotic events. Despite these universal tasks, lamins have so far been found only in metazoans. Yet, recently we have identified Dictyostelium NE81 as the first lamin-like protein in a lower eukaryote. Based on the current knowledge, we draw a model for nuclear envelope organization in Dictyostelium in this Extra View and we review the experimental data that justified this classification. Furthermore we provide unpublished data underscoring the requirement of posttranslational CaaX-box processing for proper protein localization at the nuclear envelope. Sequence comparison of NE81 sequences from four Dictyostelia with bona fide lamins illustrates the evolutional relationship between these proteins. Under certain conditions these usually unicellular social amoebae congregate to form a multicellular body. We propose that the evolution of the lamin-like NE81 went along with the invention of multicellularity.
KW  - dictyostelium
KW  - lamin
KW  - intermediate filament
KW  - centrosome
KW  - nucleus
Y1  - 2012
U6  - https://doi.org/10.4161/nucl.20149
SN  - 1949-1034
VL  - 3
IS  - 3
SP  - 237
EP  - 243
PB  - Landes Bioscience
CY  - Austin
ER  -