TY - JOUR A1 - Baur, Heiner A1 - Hirschmüller, Anja A1 - Müller, Steffen A1 - Cassel, Michael A1 - Mayer, Frank T1 - Is EMG of the lower leg dependent on weekly running mileage? JF - International journal of sports medicine N2 - Neuromuscular activity of the lower leg is dependent on the task performed, speed of movement and gender. Whether training volume influences neuromuscular activity is not known. The EMG of physically active persons differing in running mileage was analysed to investigate this. 55 volunteers were allocated to a low (LM: < 30 km), intermediate (IM: > 30 km & < 45 km) or high mileage (HM: > 45 km) group according to their weekly running volume. Neuromuscular activity of the lower leg was measured during running (3.33 m.s(-1)). Mean amplitude values for preactivation, weight acceptance and push-off were calculated and normalised to the mean activity of the entire gait cycle. Higher activity in the gastrocnemius group was observed in weight acceptance in LM compared to IM (+30%) and HM (+25%) but lower activity was present in the push-off for LM compared to IM and HM. For the peroneal muscle, differences were present in the push-off where HM showed increased activity compared to IM (+24%) and LM (+60%). The tibial muscle revealed slightly lower activity during preactivation for the high mileage runners. Neuromuscular activity differs during stance between the high and intermediate group compared to low mileage runners. Slight adaptations in neuromuscular activation indicate a more target-oriented activation strategy possibly due to repetitive training in runners with higher weekly mileage. KW - locomotion KW - neuromuscular control KW - running gait KW - training volume Y1 - 2012 U6 - https://doi.org/10.1055/s-0031-1286250 SN - 0172-4622 VL - 33 IS - 1 SP - 53 EP - 57 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Bonaventura, Klaus A1 - Leber, Alexander W. A1 - Sohns, Christian A1 - Roser, Mattias A1 - Boldt, Leif-Hendrik A1 - Kleber, Franz X. A1 - Haverkamp, Wilhelm A1 - Dorenkamp, Marc T1 - Cost-effectiveness of paclitaxel-coated balloon angioplasty and paclitaxel-eluting stent implantation for treatment of coronary in-stent restenosis in patients with stable coronary artery disease JF - Clinical research in cardiology : official journal of the German Cardiac Society. N2 - Recent studies have demonstrated the safety and efficacy of drug-coated balloon (DCB) angioplasty for the treatment of coronary in-stent restenosis (ISR). The cost-effectiveness of this practice is unknown. A Markov state-transition decision analytic model accounting for varying procedural efficacy rates, complication rates, and cost estimates was developed to compare DCB angioplasty with drug-eluting stent (DES) placement in patients with bare-metal stent (BMS)-ISR. Data on procedural outcomes associated with both treatment strategies were derived from the literature, and the cost analysis was conducted from a health care payer perspective. Effectiveness was expressed as life-years gained. In the base-case analysis, initial procedure costs amounted to a,not sign3,604.14 for DCB angioplasty and to a,not sign3,309.66 for DES implantation. Over a 12-month time horizon, the DCB strategy was found to be less costly (a,not sign4,130.38 vs. a,not sign5,305.30) and slightly more effective in terms of life expectancy (0.983 vs. 0.976 years) than the DES strategy. Extensive sensitivity analyses indicated that, in comparison with DES implantation, the cost advantage of the DCB strategy was robust to clinically plausible variations in the values of key model input parameters. The variables with the greatest impact on base-case results were the duration of dual antiplatelet therapy with acetylsalicylic acid and clopidogrel after DCB angioplasty, the use of generic clopidogrel, and variations in the costs associated with the DCB device. DCB angioplasty is a cost-effective treatment option for coronary BMS-ISR. The higher initial costs of DCB are more than offset by later cost-savings, predominantly as a result of reduced medication costs. KW - Cost-effectiveness KW - Drug-coated balloon KW - Drug-eluting stent KW - Restenosis KW - Revascularization Y1 - 2012 U6 - https://doi.org/10.1007/s00392-012-0428-2 SN - 1861-0684 VL - 101 IS - 7 SP - 573 EP - 584 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Carlsohn, Anja A1 - Nippe, Susanne A1 - Heydenreich, Juliane A1 - Mayer, Frank T1 - Carbohydrate intake and food sources of junior triathletes during a moderate and an intensive training period JF - International journal of sport nutrition and exercise metabolism N2 - The study was conducted to investigate the quantity and the main food sources of carbohydrate (CHO) intake of junior elite triathletes during a short-term moderate (MOD; 12 km swimming, 100 km cycling, 30 km running per wk) and intensive training period (INT; 23 km swimming, 200 km cycling, 45 km running per wk). Self-reported dietary-intake data accompanied by training protocols of 7 male triathletes (18.1 +/- 2.4 yr, 20.9 +/- 1.4 kg/m(2)) were collected on 7 consecutive days during both training periods in the same competitive season. Total energy and CHO intake were calculated based on the German Food Database. A paired t test was applied to test for differences between the training phases (alpha = .05). CHO intake was slightly higher in INT than in MOD (9.0 +/- 1.6 g . kg(-1) . d(-1) vs. 7.8 +/- 1.6 g . kg(-1) . d(-1); p = .041). Additional CHO in INT was mainly ingested during breakfast (115 +/- 37 g in MOD vs. 175 +/- 23 g in INT; p = .002) and provided by beverages (280.5 +/- 97.3 g/d vs. 174.0 +/- 58.3 g/d CHO; p = .112). Altogether, main meals provided approximately two thirds of the total CHO intake. Pre- and postexercise snacks additionally supplied remarkable amounts of CHO (198.3 +/- 84.3 g/d in INT vs. 185.9 +/- 112 g/d CHO in MOD; p = .231). In conclusion, male German junior triathletes consume CHO in amounts currently recommended for endurance athletes during moderate to intensive training periods. Main meals provide the majority of CHO and should therefore not be skipped. CHO-containing beverages, as well as pre- and postexercise snacks, may provide a substantial amount of CHO intake in training periods with high CHO requirements. KW - carbohydrate sources KW - endurance athletes KW - meal schedule KW - beverages Y1 - 2012 SN - 1526-484X VL - 22 IS - 6 SP - 438 EP - 443 PB - Human Kinetics Publ. CY - Champaign ER - TY - JOUR A1 - Heneghan, Carl A1 - Ward, Alison A1 - Perera, Rafael A1 - Bankhead, Clare A1 - Fuller, Alice A1 - Stevens, Richard A1 - Bradford, Kairen A1 - Tyndel, Sally A1 - Alonso-Coello, Pablo A1 - Ansell, Jack A1 - Beyth, Rebecca A1 - Bernardo, Artur A1 - Christensen, Thomas Decker A1 - Cromheecke, Manon A1 - Edson, Robert G A1 - Fitzmaurice, David A1 - Gadisseur, Alain PA A1 - Garcia-Alamino, Josep M A1 - Gardiner, Chris A1 - Hasenkam, Michael A1 - Jacobson, Alan A1 - Kaatz, Scott A1 - Kamali, Farhad A1 - Khan, Tayyaba Irfan A1 - Knight, Eve A1 - Kortke, Heinrich A1 - Levi, Marcel A1 - Matchar, David Bruce A1 - Menendez-Jandula, Barbara A1 - Rakovac, Ivo A1 - Schaefer, Christian A1 - Siebenhofer, Andrea A1 - Souto, Juan Carlos A1 - Sunderji, Rubina A1 - Gin, Kenneth A1 - Shalansky, Karen A1 - Völler, Heinz A1 - Wagner, Otto A1 - Zittermann, Armin T1 - Self-monitoring of oral anticoagulation systematic review and meta-analysis of individual patient data JF - The lancet N2 - Background Uptake of self-testing and self-management of oral coagulation has remained inconsistent, despite good evidence of their effectiveness. To clarify the value of self-monitoring of oral anticoagulation, we did a meta-analysis of individual patient data addressing several important gaps in the evidence, including an estimate of the effect on time to death, first major haemorrhage, and thromboembolism. Methods We searched Ovid versions of Embase (1980-2009) and Medline (1966-2009), limiting searches to randomised trials with a maximally sensitive strategy. We approached all authors of included trials and requested individual patient data: primary outcomes were time to death, first major haemorrhage, and first thromboembolic event. We did prespecified subgroup analyses according to age, type of control-group care (anticoagulation-clinic care vs primary care), self-testing alone versus self-management, and sex. We analysed patients with mechanical heart valves or atrial fibrillation separately. We used a random-effect model method to calculate pooled hazard ratios and did tests for interaction and heterogeneity, and calculated a time-specific number needed to treat. Findings Of 1357 abstracts, we included 11 trials with data for 6417 participants and 12 800 person-years of follow-up. We reported a significant reduction in thromboembolic events in the self-monitoring group (hazard ratio 0.51; 95% CI 0.31-0.85) but not for major haemorrhagic events (0.88, 0.74-1.06) or death (0.82, 0.62-1.09). Participants younger than 55 years showed a striking reduction in thrombotic events (hazard ratio 0.33, 95% CI 0.17-0.66), as did participants with mechanical heart valve (0.52, 0.35-0.77). Analysis of major outcomes in the very elderly (age >= 85 years, n=99) showed no significant adverse effects of the intervention for all outcomes. Interpretation Our analysis showed that self-monitoring and self-management of oral coagulation is a safe option for suitable patients of all ages. Patients should also be offered the option to self-manage their disease with suitable health-care support as back-up. Y1 - 2012 U6 - https://doi.org/10.1016/S0140-6736(11)61294-4 SN - 0140-6736 VL - 379 IS - 9813 SP - 322 EP - 334 PB - Elsevier CY - New York ER - TY - JOUR A1 - Hirschmueller, Anja A1 - Frey, Victoria A1 - Konstantinidis, Lukas A1 - Baur, Heiner A1 - Dickhuth, Hans-Hermann A1 - Suedkamp, Norbert P. A1 - Helwig, Peter T1 - Prognostic value of achilles tendon doppler sonography in asymptomatic runners JF - Medicine and science in sports and exercise : official journal of the American College of Sports Medicine N2 - HIRSCHMULLER, A., V. FREY, L. KONSTANTINIDIS, H. BAUR, H-H. DICKHUTH, N. P. SUDKAMP, and P. HELWIG. Prognostic Value of Achilles Tendon Doppler Sonography in Asymptomatic Runners. Med. Sci. Sports Exerc., Vol. 44, No. 2, pp. 199-205, 2012. Introduction: Midportion Achilles tendinopathy (MPT) is a common problem in running athletes. Nevertheless, its etiology is not fully understood, and no valid prognostic criterion to predict the development of MPT could be identified to date. The purpose of the present study, therefore, was to evaluate whether power Doppler ultrasonography (PDU) is a suitable method to identify a predisposition to MPT in yet asymptomatic runners. Methods: At 23 major running events, 634 asymptomatic long-distance runners were tested for Achilles tendon thickness, vascularization, and structural abnormalities using a high-resolution PDU device (Toshiba Aplio SSA-770A/80, 12 MHz). In addition, their medical history and anthropometric data were documented. All subjects were contacted 6 and 12 months later and asked about any new symptoms. The collected anamnestic, anthropometric, and ultrasonographic data were subjected to regression analysis to determine their predictive value concerning the manifestation of midportion Achilles tendon complaints (P < 0.05). Results: The highest odds ratio (OR) for manifestation of MPT within 1 yr was found for intratendinous blood flow ("neovascularization,'' OR = 6.9, P < 0.001). An increased risk was also identified for subjects with a positive history of Achilles tendon complaints (OR = 3.8, P < 0.001). A third relevant parameter, just above the level of significance, was a spindle-shaped thickening of the tendon on PDU (Wald chi(2) = 3.42). Conclusions: PDU detection of intratendinous microvessels in the Achilles tendons of healthy runners seems to be a prognostically relevant factor concerning the manifestation of symptomatic MPT. This finding lays the foundation for an early identification of a predisposition to MPT as well as prophylactic intervention in as yet asymptomatic runners. KW - MIDPORTION KW - TENDINOPATHY KW - NEOVASCULARIZATION KW - PROGNOSIS Y1 - 2012 U6 - https://doi.org/10.1249/MSS.0b013e31822b7318 SN - 0195-9131 VL - 44 IS - 2 SP - 199 EP - 205 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Mayer, Frank A1 - Bonaventura, Klaus A1 - Cassel, Michael A1 - Müller, Steffen A1 - Weber, Josefine A1 - Scharhag-Rosenberger, Friederike A1 - Carlsohn, Anja A1 - Baur, Heiner A1 - Scharhag, Jürgen T1 - Medical results of preparticipation examination in adolescent athletes JF - British journal of sports medicine : the journal of sport and exercise medicine N2 - Background Preparticipation examinations (PPE) are frequently used to evaluate eligibility for competitive sports in adolescent athletes. Nevertheless, the effectiveness of these examinations is under debate since costs are high and its validity is discussed controversial. Purpose To analyse medical findings and consequences in adolescent athletes prior to admission to a sports school. Methods In 733 adolescent athletes (318 girls, 415 boys, age 12.3+/-0.4, 16 sports disciplines), history and clinical examination (musculoskeletal, cardiovascular, general medicine) was performed to evaluate eligibility. PPE was completed by determination of blood parameters, ECG at rest and during ergometry, echocardiography and x-rays and ultrasonography if indicated. Eligibility was either approved or rated with restriction. Recommendations for therapy and/or prevention were given to the athletes and their parents. Results Historical (h) and clinical (c) findings (eg, pain, verified pathologies) were more frequent regarding the musculoskeletal system (h: 120, 16.4%; c: 247, 33.7%) compared to cardiovascular (h: 9, 1.2%; c: 23, 3.1%) or general medicine findings (h: 116, 15.8%; c: 71, 9.7%). ECG at rest was moderately abnormal in 46 (6.3%) and severely abnormal in 25 athletes (3.4%). Exercise ECG was suspicious in 25 athletes (3.4%). Relevant echocardiographic abnormalities were found in 17 athletes (2.3%). In 52 of 358 cases (14.5%), x-rays led to diagnosis (eg, Spondylolisthesis). Eligibility was temporarily restricted in 41 athletes (5.6%). Three athletes (0.4%) had to be excluded from competitive sports. Therapy (eg, physiotherapy, medication) and/or prevention (sensorimotor training, vaccination) recommendations were deduced due to musculoskeletal (t:n = 76,10.3%; p:n = 71,9.8%) and general medicine findings (t:n = 80, 10.9%; p:n = 104, 14.1%). Conclusion Eligibility for competitive sports is restricted in only 5.5% of adolescent athletes at age 12. Eligibility refusals are rare. However, recommendations for therapy and prevention are frequent, mainly regarding the musculoskeletal system. In spite of time and cost consumption, adolescent preparticipation before entering a career in high-performance sports is supported. Y1 - 2012 U6 - https://doi.org/10.1136/bjsports-2011-090966 SN - 0306-3674 VL - 46 IS - 7 SP - 524 EP - 530 PB - BMJ Publ. Group CY - London ER - TY - JOUR A1 - Mühlbauer, Thomas A1 - Besemer, Carmen A1 - Wehrle, Anja A1 - Gollhofer, Albert A1 - Granacher, Urs T1 - Relationship between strength, power and balance performance in seniors JF - Gerontology N2 - Background: Deficits in strength, power and balance represent important intrinsic risk factors for falls in seniors. Objective: The purpose of this study was to investigate the relationship between variables of lower extremity muscle strength/power and balance, assessed under various task conditions. Methods: Twenty-four healthy and physically active older adults (mean age: 70 8 5 years) were tested for their isometric strength (i.e. maximal isometric force of the leg extensors) and muscle power (i.e. countermovement jump height and power) as well as for their steady-state (i.e. unperturbed standing, 10-meter walk), proactive (i.e. Timed Up & Go test, Functional Reach Test) and reactive (i.e. perturbed standing) balance. Balance tests were conducted under single (i.e. standing or walking alone) and dual task conditions (i.e. standing or walking plus cognitive and motor interference task). Results: Significant positive correlations were found between measures of isometric strength and muscle power of the lower extremities (r values ranged between 0.608 and 0.720, p < 0.01). Hardly any significant associations were found between variables of strength, power and balance (i.e. no significant association in 20 out of 21 cases). Additionally, no significant correlations were found between measures of steady-state, proactive and reactive balance or balance tests performed under single and dual task conditions (all p > 0.05). Conclusion: The predominately nonsignificant correlations between different types of balance imply that balance performance is task specific in healthy and physically active seniors. Further, strength, power and balance as well as balance under single and dual task conditions seem to be independent of each other and may have to be tested and trained complementarily. KW - Steady-state balance KW - Proactive/reactive balance KW - Force production KW - Single/dual tasking KW - Cognitive/motor interference Y1 - 2012 U6 - https://doi.org/10.1159/000341614 SN - 0304-324X VL - 58 IS - 6 SP - 504 EP - 512 PB - Karger CY - Basel ER - TY - JOUR A1 - Mühlbauer, Thomas A1 - Gollhofer, Albert A1 - Granacher, Urs T1 - Sex-related effects in strength training during adolescence a pilot study JF - Perceptual & motor skills N2 - The objective was to investigate the effects of high-velocity strength training on isometric strength of the leg extensors and jump height in female and male adolescents. Twenty-eight students (13 boys, 15 girls) ages 16 to 17 years participated in this study and were assigned to either a strength training group or a control group. Strength training was conducted over 8 weeks (2 times per week). Pre- and post-training tests included the measurements of maximal isometric force and rate of force development of the leg extensors as well as countermovement jump height. Both girls (effect size = 1.37) and boys (effect size = 0.61) showed significant improvements in jump height. However, significant increases in maximal isometric force (effect size = 1.85) and rate of force development (effect size = 2.23) were found only in girls. In female and male adolescents, high-velocity strength training is an effective training regimen that produced improvements in countermovement jump height in both sexes but higher gains in maximal isometric force and rate of force development in girls. Y1 - 2012 U6 - https://doi.org/10.2466/06.10.30.PMS.115.6.953-968 SN - 0031-5125 VL - 115 IS - 3 SP - 953 EP - 968 PB - Sage Publ. CY - Missoula ER - TY - JOUR A1 - Mühlbauer, Thomas A1 - Stürchler, M. A1 - Granacher, Urs T1 - Effects of climbing on core strength and mobility in adults JF - International journal of sports medicine N2 - The objective of this study was to examine the impact of an indoor climbing training and detraining program on core/handgrip strength and trunk mobility in men and women. 28 young sedentary adults participated in this study and were assigned to an intervention (30+/-3 years) or a control (29+/-2 years) group. The intervention group participated in 8 weeks (2 times/week) of indoor climbing training, followed by 8 weeks of detraining. Tests included the measurement of maximal isometric strength (MIS) of the trunk flexors/extensors, the assessment of trunk mobility in the sagittal (SAP) and the coronal (CRP) plane as well as testing of handgrip strength. After training, significant improvements were observed in MIS of the trunk flexors/extensors (similar to 19-22 %, all p<0.01), in trunk mobility in SAP/CRP (similar to 14-19 %, all p<0.01), and in handgrip strength (similar to 5 %, p<0.01). During detraining, MIS (similar to 12-13 %, all p<0.01) and trunk mobility (similar to 7-10%, all p<0.01) deteriorated significantly, whereas handgrip strength remained. This indoor climbing training program conducted in sedentary adults proved to be feasible (i.e., attendance rate of 89.4%) and effective. It is suggested that indoor climbing should be permanently conducted to maintain the observed improvements in core muscle strength and trunk mobility. KW - intervention KW - detraining KW - young adults KW - sedentary Y1 - 2012 U6 - https://doi.org/10.1055/s-0031-1301312 SN - 0172-4622 VL - 33 IS - 6 SP - 445 EP - 451 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Müller, Steffen A1 - Carlsohn, Anja A1 - Müller, Juliane A1 - Baur, Heiner A1 - Mayer, Frank T1 - Static and dynamic foot characteristics in children aged 1-13 years a cross-sectional study JF - Gait & posture N2 - The aim of this study was to acquire static and dynamic foot geometry and loading in childhood, and to establish data for age groups of a population of 1-13 year old infants and children. A total of 10,382 children were recruited and 7788 children (48% males and 52% females) were finally included into the data analysis. For static foot geometry foot length and foot width were quantified in a standing position. Dynamic foot geometry and loading were assessed during walking on a walkway with self selected speed (Novel Emed X, 100 Hz, 4 sensors/cm(2)). Contact area (CA), peak pressure (PP), force time integral (FTI) and the arch index were calculated for the total, fore-, mid- and hindfoot. Results show that most static and dynamic foot characteristics change continuously during growth and maturation. Static foot length and width increased with age from 13.1 +/- 0.8 cm (length) and 5.7 +/- 0.4 cm (width) in the youngest to 24.4 +/- 1.5 cm (length) and 8.9 +/- 0.6 cm (width) in the oldest. A mean walking velocity of 0.94 +/- 0.25 m/s was observed. Arch-index ranged from 0.32 +/- 0.04 [a.u.] in the one-year old to 0.21 +/- 0.13 [a.u.] in the 5-year olds and remains constant afterwards. This study provides data for static and dynamic foot characteristics in children based on a cohort of 7788 subjects. Static and dynamic foot measures change differently during growth and maturation. Dynamic foot measurements provide additional information about the children's foot compared to static measures. KW - Children KW - Foot KW - Geometry KW - Arch-index KW - Plantar pressure Y1 - 2012 U6 - https://doi.org/10.1016/j.gaitpost.2011.10.357 SN - 0966-6362 VL - 35 IS - 3 SP - 389 EP - 394 PB - Elsevier CY - Clare ER -