TY  - JOUR
A1  - Wessig, Pablo
A1  - Merkel, Roswitha
A1  - Mueller, Peter
T1  - Articulated rods - a novel class of molecular rods based on oligospiroketals (OSK)
JF  - Beilstein journal of organic chemistry
N2  - We developed a new type of molecular rods consisting of two (or more) rigid units linked by a flexible joint. Consequently we called these constructs articulated rods (ARs). The syntheses of ARs were carried out by a flexible and modular approach providing access to a number of compounds with various functionalizations in terminal positions. First applications were presented with pyrene, cinnamoyl and anthracenyl labelled ARs.
KW  - articulated rods
KW  - click chemistry
KW  - molecular rods
KW  - oligospiroketals
KW  - pyrene excimer
Y1  - 2015
U6  - https://doi.org/10.3762/bjoc.11.11
SN  - 1860-5397
VL  - 11
SP  - 74
EP  - 84
PB  - Beilstein-Institut zur Förderung der Chemischen Wissenschaften
CY  - Frankfurt, Main
ER  - 
TY  - JOUR
A1  - Wessig, Pablo
A1  - Gerngroß, Maik
A1  - Pape, Simon
A1  - Bruhns, Philipp
A1  - Weber, Jens
T1  - Novel porous materials based on oligospiroketals (OSK)
JF  - RSC Advances : an international journal to further the chemical sciences
N2  - New porous materials based on covalently connected monomers are presented. The key step of the synthesis is an acetalisation reaction. In previous years we used acetalisation reactions extensively to build up various molecular rods. Based on this approach, investigations towards porous polymeric materials were conducted by us. Here we wish to present the results of these studies in the synthesis of 1D polyacetals and porous 3D polyacetals. By scrambling experiments with 1D acetals we could prove that exchange reactions occur between different building blocks (evidenced by MALDI-TOF mass spectrometry). Based on these results we synthesized porous 3D polyacetals under the same mild conditions.
KW  - microporous organic polymers
KW  - molecular rods
KW  - construction
KW  - frameworks
KW  - membranes
KW  - sorption
KW  - models
Y1  - 2014
U6  - https://doi.org/10.1039/c4ra04437a
SN  - 2046-2069
VL  - 2014
IS  - 4
SP  - 31123
EP  - 31129
ER  - 
TY  - JOUR
A1  - Wessig, Pablo
A1  - Budach, Dennis B.
A1  - Thünemann, Andreas F.
T1  - Dendrimers with Oligospiroketal (OSK) Building Blocks: Synthesis and Properties
JF  - Chemistry - a European journal
N2  - The development of novel dendrimers containing oligospiroketal (OSK) rods as building blocks is described. The linkage between the core unit (CU), branching units (BU), and OSK rods relies on the CuAAC reaction between terminal alkynes and azides. Two different strategies of dendrimer synthesis were investigated and it was found that the convergent approach is clearly superior to the divergent one. SAXS measurements and MD simulations indicate that the obtained dendrimer features a globular structure with very low density. Obviously, the OSK rods stabilize a rather loose mass-fractal structure.
KW  - click chemistry
KW  - dendrimers
KW  - molecular rods
KW  - oxygen heterocycles
KW  - SAXS
Y1  - 2015
U6  - https://doi.org/10.1002/chem.201501386
SN  - 0947-6539
SN  - 1521-3765
VL  - 21
IS  - 29
SP  - 10466
EP  - 10471
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Grimm, Christiane
A1  - Meyer, Thomas
A1  - Czapla, Sylvia
A1  - Nikolaus, Jörg
A1  - Scheidt, Holger A.
A1  - Vogel, Alexander
A1  - Herrmann, Andreas
A1  - Wessig, Pablo
A1  - Huster, Daniel
A1  - Müller, Peter
T1  - Structure and dynamics of molecular rods in membranes application of a Spin-Labeled rod
JF  - Chemistry - a European journal
N2  - Molecular rods consisting of a hydrophobic backbone and terminally varying functional groups have been synthesized for applications for the functionalization of membranes. In the present study, we employ a spin-labeled analogue of a recently described new class of molecular rods to characterize their dynamic interactions with membranes. By using the different approaches of ESR and NMR spectroscopy, we show that the spin moiety of the membrane-embedded spin-labeled rod is localized in the upper chain/glycerol region of membranes of different compositions. The rod is embedded within the membrane in a tilted orientation to adjust for the varying hydrophobic thicknesses of these bilayers. This orientation does not perturb the membrane structure. The water solubility of the rod is increased significantly in the presence of certain cyclodextrins. These cyclodextrins also allow the rods to be extracted from the membrane and incorporated into preformed membranes. The latter will improve the future applications of these rods in cellular systems as stable membrane-associated anchors for the functionalization of membrane surfaces.
KW  - hydrophobic mismatch
KW  - membranes
KW  - molecular rods
KW  - phospholipids
KW  - spiro compounds
Y1  - 2013
U6  - https://doi.org/10.1002/chem.201202500
SN  - 0947-6539
VL  - 19
IS  - 8
SP  - 2703
EP  - 2710
PB  - Wiley-VCH
CY  - Weinheim
ER  -