TY  - JOUR
A1  - Perez-Anes, Alexandra
A1  - Rodrigues, Fernanda
A1  - Caminade, Anne-Marie
A1  - Stefaniu, Cristina
A1  - Tiersch, Brigitte
A1  - Turrin, Cedric-Olivier
A1  - Blanzat, Muriel
T1  - Influence of structural parameters on the self-association properties of anti-HIV catanionic dendrimers
JF  - ChemPhysChem : a European journal of chemical physics and physical chemistry
N2  - The self-association properties of anti-HIV catanionic dendrimers as multivalent galactosylceramide (GalCer)-derived inhibitors are presented. The study was designed to elucidate the origin of the relatively high cytotoxicity values of these antiHIV catanionic dendrimers, which have previously been found to exhibit in vitro anti-HIV activity in the submicromolar range. The physicochemical properties of these catanionic dendrimers were studied to tentatively correlate the structural parameters with self-association and biological properties. We can conclude from this study that the absence of correlation between the hydrophobicity and the cytotoxicity of the catanionic systems could be explained by the partial segregation of the different partners of the catanionic entities.
KW  - anti-HIV
KW  - catanionic surfactants
KW  - dendrimers
KW  - galactosylceramide
KW  - glycolipids
Y1  - 2015
U6  - https://doi.org/10.1002/cphc.201500484
SN  - 1439-4235
SN  - 1439-7641
VL  - 16
IS  - 16
SP  - 3433
EP  - 3437
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Wessig, Pablo
A1  - Budach, Dennis B.
A1  - Thünemann, Andreas F.
T1  - Dendrimers with Oligospiroketal (OSK) Building Blocks: Synthesis and Properties
JF  - Chemistry - a European journal
N2  - The development of novel dendrimers containing oligospiroketal (OSK) rods as building blocks is described. The linkage between the core unit (CU), branching units (BU), and OSK rods relies on the CuAAC reaction between terminal alkynes and azides. Two different strategies of dendrimer synthesis were investigated and it was found that the convergent approach is clearly superior to the divergent one. SAXS measurements and MD simulations indicate that the obtained dendrimer features a globular structure with very low density. Obviously, the OSK rods stabilize a rather loose mass-fractal structure.
KW  - click chemistry
KW  - dendrimers
KW  - molecular rods
KW  - oxygen heterocycles
KW  - SAXS
Y1  - 2015
U6  - https://doi.org/10.1002/chem.201501386
SN  - 0947-6539
SN  - 1521-3765
VL  - 21
IS  - 29
SP  - 10466
EP  - 10471
PB  - Wiley-VCH
CY  - Weinheim
ER  -