TY  - JOUR
A1  - Yang, Xiaoping
A1  - Darko, Kwame Oteng
A1  - Huang, Yanjun
A1  - He, Caimei
A1  - Yang, Huansheng
A1  - He, Shanping
A1  - Li, Jianzhong
A1  - Li, Jian
A1  - Hocher, Berthold
A1  - Yin, Yulong
T1  - Resistant starch regulates gut microbiota
BT  - structure, biochemistry and cell signalling
JF  - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology
N2  - Starch is one of the most popular nutritional sources for both human and animals. Due to the variation of its nutritional traits and biochemical specificities, starch has been classified into rapidly digestible, slowly digestible and resistant starch. Resistant starch has its own unique chemical structure, and various forms of resistant starch are commercially available. It has been found being a multiple-functional regulator for treating metabolic dysfunction. Different functions of resistant starch such as modulation of the gut microbiota, gut peptides, circulating growth factors, circulating inflammatory mediators have been characterized by animal studies and clinical trials. In this mini-review, recent remarkable progress in resistant starch on gut microbiota, particularly the effect of structure, biochemistry and cell signaling on nutrition has been summarized, with highlights on its regulatory effect on gut microbiota.
KW  - Resistant starch
KW  - Gut microbiota
KW  - Nutrition
Y1  - 2017
U6  - https://doi.org/10.1159/000477386
SN  - 1015-8987
SN  - 1421-9778
VL  - 42
IS  - 1
SP  - 306
EP  - 318
PB  - Karger
CY  - Basel
ER  - 
TY  - JOUR
A1  - Reichetzeder, Christoph
A1  - Putra, Sulistyo Emantoko Dwi
A1  - Li, Jian
A1  - Hocher, Berthold
T1  - Developmental Origins of Disease - Crisis Precipitates Change
JF  - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology
N2  - The concept of developmental origins of diseases has gained a huge interest in recent years and is a constantly emerging scientific field. First observations hereof originated from epidemiological studies, linking impaired birth outcomes to adult chronic, noncommunicable disease. By now there is a considerable amount of both epidemiological and experimental evidence highlighting the impact of early life events on later life disease susceptibility. Albeit far from being completely understood, more recent studies managed to elucidate underlying mechanisms, with epigenetics having become almost synonymous with developmental programming. The aim of this review was to give a comprehensive overview of various aspects and mechanisms of developmental origins of diseases. Starting from initial research foci mainly centered on a nutritionally impaired intrauterine environment, more recent findings such as postnatal nutrition, preterm birth, paternal programming and putative interventional approaches are summarized. The review outlines general underlying mechanisms and particularly discusses mechanistic explanations for sexual dimorphism in developmental programming. Furthermore, novel hypotheses are presented emphasizing a non-mendelian impact of parental genes on the offspring's phenotype.
KW  - Nutrition
KW  - Thrifty phenotype
KW  - Developmental programming
KW  - Paternal, maternal, sex differences
KW  - Epigenetics
Y1  - 2016
U6  - https://doi.org/10.1159/000447801
SN  - 1015-8987
SN  - 1421-9778
VL  - 39
SP  - 919
EP  - 938
PB  - Karger
CY  - Basel
ER  -