TY  - JOUR
A1  - Adem, Fozia A.
A1  - Kuete, Victor
A1  - Mbaveng, Armelle T.
A1  - Heydenreich, Matthias
A1  - Ndakala, Albert
A1  - Irungu, Beatrice
A1  - Efferth, Thomas
A1  - Yenesew, Abiy
T1  - Cytotoxic benzylbenzofuran derivatives from Dorstenia kameruniana
JF  - Fitoterapia
N2  - Chromatographic separation of the extract of the roots of Dorstenia kameruniana (family Moraceae) led to the isolation of three new benzylbenzofuran derivatives, 2-(p-hydroxybenzyl)benzofuran-6-ol (1), 2-(p-hydroxybenzyl)-7-methoxybenzofuran-6-ol (2) and 2-(p-hydroxy)-3-(3-methylbut-2-en-1-yl)benzyl)benzofuran-6-ol (3) (named dorsmerunin A, B and C, respectively), along with the known furanocoumarin, bergapten (4). The twigs of Dorstenia kameruniana also produced compounds 1-4 as well as the known chalcone licoagrochalcone A (5). The structures were elucidated by NMR spectroscopy and mass spectrometry. The isolated compounds displayed cytotoxicity against the sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells, where compounds 4 and 5 had the highest activities (IC50 values of 7.17 mu M and 5.16 mu M, respectively) against CCRF-CEM leukemia cells. Compound 5 also showed cytotoxicity against 7 sensitive or drug-resistant solid tumor cell lines (breast carcinoma, colon carcinoma, glioblastoma), with IC50 below 50 mu M, whilst 4 showed selective activity.
KW  - Dorstenia kameruniana
KW  - Moraceae
KW  - Benzylbenzofuran
KW  - Furanocoumarin
KW  - Chalcone
KW  - Cytotoxicity
Y1  - 2018
U6  - https://doi.org/10.1016/j.fitote.2018.04.019
SN  - 0367-326X
SN  - 1873-6971
VL  - 128
SP  - 26
EP  - 30
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Abdissa, Negera
A1  - Heydenreich, Matthias
A1  - Midiwo, Jacob O.
A1  - Ndakala, Albert
A1  - Majer, Zsuzsanna
A1  - Neumann, Beate
A1  - Stammler, Hans-Georg
A1  - Sewald, Norbert
A1  - Yenesew, Abiy
T1  - A xanthone and a phenylanthraquinone from the roots of Bulbine frutescens, and the revision of six seco-anthraquinones into xanthones
JF  - Phytochemistry letters
N2  - Phytochemical investigation of the dichloromethane/methanol (1:1) extract of the roots of Bulbine frutescens led to the isolation of a new xanthone, 8-hydroxy-6-methylxanthone-1-carboxylic acid (1) and a new phenylanthraquinone, 6',8-O-dimethylknipholone (2) along with six known compounds. The structures were elucidated on the basis of NMR and MS spectral data analyses. The structure of compound 1 was confirmed through X-ray crystallography which was then used as a reference to propose the revision of the structures of six seco-anthraquinones into xanthones. The isolated compounds were evaluated for cytotoxicity against human cervix carcinoma KB-3-1 cells with the phenylanthraquinone knipholone being the most active (IC50 = 0.43 mu M). Two semi-synthetic knipholone derivatives, knipholone Mannich base and knipholone-1,3-oxazine, were prepared and tested for cytotoxic activity; both showed moderate activities (IC50 value of 1.89 and 2.50 mu M, respectively). (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
KW  - Bulbine frutescens
KW  - Xanthone
KW  - seco-Anthraquinone
KW  - Phenylanthraquinone
KW  - Cytotoxicity
KW  - Structure revision
Y1  - 2014
U6  - https://doi.org/10.1016/j.phytol.2014.04.004
SN  - 1874-3900
SN  - 1876-7486
VL  - 9
SP  - 67
EP  - 73
PB  - Elsevier
CY  - Amsterdam
ER  -