TY  - JOUR
A1  - Ferir, Geoffrey
A1  - Vermeire, Kurt
A1  - Huskens, Dana
A1  - Balzarini, Jan
A1  - Van Damme, Els J. M.
A1  - Kehr, Jan-Christoph
A1  - Dittmann-Thünemann, Elke
A1  - Swanson, Michael D.
A1  - Markovitz, David M.
A1  - Schols, Dominique
T1  - Synergistic in vitro anti-HIV type 1 activity of tenofovir with carbohydrate-binding agents (CBAs)
JF  - Antiviral research
N2  - Tenofovir, a well-known and highly prescribed anti-HIV-1 drug for the treatment of HIV/AIDS infections, has recently also shown its effectiveness as a potential microbicide drug in the prevention of HIV transmission.
 Here, we evaluated the combination of tenofovir with various members of the class of carbohydrate-binding agents (CBAs) targeting the glycans on the viral envelope gp120 for their anti-HIV efficacy. The tenofovir/CBA combinations predominantly showed synergistic antiviral activity using the median effect principle.
 These findings illustrate that combination of tenofovir with CBAs may increase the antiviral potency of the individual drugs and reducing the risk on potential side-effects.
KW  - Tenofovir
KW  - Carbohydrate-binding agents
KW  - HIV
KW  - Synergy
KW  - Microbicide
Y1  - 2011
U6  - https://doi.org/10.1016/j.antiviral.2011.03.188
SN  - 0166-3542
VL  - 90
IS  - 3
SP  - 200
EP  - 204
PB  - Elsevier
CY  - Amsterdam
ER  -