TY  - JOUR
A1  - Chupeerach, Chaowanee
A1  - Tungtrongchitr, Anchalee
A1  - Phonrat, Benjaluck
A1  - Schweigert, Florian J.
A1  - Tungtrongchitr, Rungsunn
A1  - Preutthipan, Sangchai
T1  - Association of Thr420Lys polymorphism in DBP gene with fat-soluble vitamins and low radial bone mineral density in postmenopausal Thai women
JF  - Biomarkers in medicine
N2  - Aims: To investigate the genetic markers for osteoporosis bone mineral density by the genotyping of rs7041, rs4588 and rs1352845 in the DBP gene with either bone mineral density or serum 25-hydroxycholecalciferol, retinol and alpha-tocopherol, among 365 postmenopausal Thai women. Materials & methods: The DBP genotypes were analyzed by a PCR restriction fragment-length polymorphism method. Serum 25-hydroxycholecalciferol was assessed using a commercial chemiluminescent immunoassay. Serum retinol and alpha-tocopherol were measured by reverse-phase high-performance liquid chromatography. Results: After adjustment for age >50 years, elder Thai subjects with low BMI (<= 25 kg/m(2)) and carrying the rs4588 CC genotype had a higher risk of radial bone mineral density osteoporosis (odds ratio: 6.29; p = 0.048). The rs1352845 genotype also had a statistical association with total hip bone mineral density; however, it disappeared after adjustment for age and BMI. No association was found in fat-soluble vitamins with bone mineral density. Conclusion: DBP genotypes may influence the osteoporosis bone mineral density in postmenopausal Thai women.
KW  - bone mineral density
KW  - fat-soluble vitamin
KW  - osteoporosis
KW  - single nucleotide polymorphism
KW  - vitamin D binding protein
Y1  - 2012
U6  - https://doi.org/10.2217/BMM.11.88
SN  - 1752-0363
VL  - 6
IS  - 1
SP  - 103
EP  - 108
PB  - Future Medicine
CY  - London
ER  -