TY - JOUR A1 - Heidler, Maria-Dorothea T1 - Kognitive Störungen bei Patienten mit Herzerkrankungen T1 - Cognitive Deficits in Patiens with Cardiac Disease BT - ein Überblick BT - an Overview JF - Zeitschrift für Neuropsychologie N2 - Patienten mit Herzerkrankung leiden unter zahlreichen kognitiven Defiziten, die mit steigendem Alter und der Schwere der kardialen Erkrankung zunehmen. Die Genese kognitiver Defizite und ihre Wechselwirkung mit Herzerkrankungen ist multifaktoriell, potenziell sind sie jedoch durch eine adäquate medizinische Behandlung der Herzerkrankung modifizierbar. Oft haben neuropsychologische Störungen wie beeinträchtigte Aufmerksamkeits-, Gedächtnis- oder Exekutivfunktionen nachhaltige Auswirkungen auf die Lebensqualität und auf das Outcome kardiologischer Rehabilitationsmaßnahmen und können Herzerkrankungen verschlimmern (bspw. durch die Aufrechterhaltung eines ungesunden Lebensstils oder unzureichende Medikamentenadhärenz). Ein routinemäßig angewandtes neuropsychologisches Screening könnte helfen, kognitiv beeinträchtigte Patienten zu identifizieren, um medizinische und rehabilitative Maßnahmen optimieren zu können. N2 - Cognitive deficits in patients with cardiac disease are common and independent of the type of heart disease present. They increase with severity of the cardiac illness and the patient’s age. The genesis of cognitive impairments and their interactions with cardiac disease is multifactorial, though cognitive deficits are potentially reversible if they receive adequate medical treatment. Yet cognitive impairments like attention deficits, memory disorders, or impairment of executive functions can lower quality of life and the outcome of cardiac rehabilitation programs. They can even aggravate cardiac disease, for example, because of an unhealthy lifestyle or insufficient medication adherence. Routinely applied neuropsychological cognitive screening could help to identify affected patients to adapt medical and rehabilitative treatment. KW - Heart failure KW - coronary heart disease KW - cardiac arrhythmia KW - heart surgery KW - Herzinsuffizienz KW - Koronare Herzkrankheit KW - Herzrhythmussörung KW - Herzoperation Y1 - 2017 U6 - https://doi.org/10.1024/1016-264X/a000193 SN - 1016-264X SN - 1664-2902 VL - 28 IS - 1 SP - 33 EP - 44 PB - Hogrefe CY - Bern ER - TY - JOUR A1 - Perez-Cornago, Aurora A1 - Crowe, Francesca L. A1 - Appleby, Paul N. A1 - Bradbury, Kathryn E. A1 - Wood, Angela M. A1 - Jakobsen, Marianne Uhre A1 - Johnson, Laura A1 - Sacerdote, Carlotta A1 - Steur, Marinka A1 - Weiderpass, Elisabete A1 - Wurtz, Anne Mette L. A1 - Kuhn, Tilman A1 - Katzke, Verena A1 - Trichopoulou, Antonia A1 - Karakatsani, Anna A1 - La Vecchia, Carlo A1 - Masala, Giovanna A1 - Tumino, Rosario A1 - Panico, Salvatore A1 - Sluijs, Ivonne A1 - Skeie, Guri A1 - Imaz, Liher A1 - Petrova, Dafina A1 - Quiros, J. Ramon A1 - Yohar, Sandra Milena Colorado A1 - Jakszyn, Paula A1 - Melander, Olle A1 - Sonestedt, Emily A1 - Andersson, Jonas A1 - Wennberg, Maria A1 - Aune, Dagfinn A1 - Riboli, Elio A1 - Schulze, Matthias Bernd A1 - di Angelantonio, Emanuele A1 - Wareham, Nicholas J. A1 - Danesh, John A1 - Forouhi, Nita G. A1 - Butterworth, Adam S. A1 - Key, Timothy J. T1 - Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort JF - International journal of epidemiology N2 - Background: Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: We conducted a prospective analysis of 490 311 men and women without a history of myocardial infarction or stroke at recruitment (12.6 years of follow-up, n cases = 8504), in 10 European countries. Dietary intake was assessed using validated questionnaires, calibrated with 24-h recalls. Multivariable Cox regressions were used to estimate hazard ratios (HR) of IHD. Results: There was a lower risk of IHD with a higher intake of fruit and vegetables combined [HR per 200 g/day higher intake 0.94, 95% confidence interval (CI): 0.90-0.99, P-trend = 0.009], and with total fruits (per 100 g/day 0.97, 0.95-1.00, P-trend = 0.021). There was no evidence for a reduced risk for fruit subtypes, except for bananas. Risk was lower with higher intakes of nuts and seeds (per 10 g/day 0.90, 0.82-0.98, Ptrend = 0.020), total fibre (per 10 g/day 0.91, 0.85-0.98, P-trend = 0.015), fruit and vegetable fibre (per 4 g/day 0.95, 0.91-0.99, P-trend = 0.022) and fruit fibre (per 2 g/day 0.97, 0.95-1.00, P-trend = 0.045). No associations were observed between vegetables, vegetables subtypes, legumes, cereals and IHD risk. Conclusions: In this large prospective study, we found some small inverse associations between plant foods and IHD risk, with fruit and vegetables combined being the most strongly inversely associated with risk. Whether these small associations are causal remains unclear. KW - fruit KW - vegetables KW - legumes KW - nuts KW - seeds KW - coronary heart disease Y1 - 2021 U6 - https://doi.org/10.1093/ije/dyaa155 SN - 0300-5771 SN - 1464-3685 VL - 50 IS - 1 SP - 212 EP - 222 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Tschorn, Mira A1 - Kuhlmann, Stella Linnea A1 - Rieckmann, Nina A1 - Beer, Katja A1 - Grosse, Laura A1 - Arolt, Volker A1 - Waltenberger, Johannes A1 - Haverkamp, Wilhelm A1 - Müller-Nordhorn, Jacqueline A1 - Hellweg, Rainer A1 - Ströhle, Andreas T1 - Brain-derived neurotrophic factor, depressive symptoms and somatic comorbidity in patients with coronary heart disease JF - Acta Neuropsychiatrica N2 - Objective: Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analysed the relationship between BDNF and depression in a sample of patients with CHD and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS) or congestive heart failure (CHF). Methods: The following variables were assessed for 225 hospitalised patients with CHD: BDNF concentrations, depression [Patient Health Questionnaire-9 (PHQ-9)], somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status and antidepressant treatment. Results: Regression models revealed that BDNF was not associated with severity of depression. Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p = 0.04), this was not statistically significant after controlling for confounders (p = 0.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p = 0.08, p = 0.06, respectively). BDNF was reduced in patients with CHF (p = 0.02). There was no covariate-adjusted, significant association between BDNF and ACS. Conclusion: Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF. KW - depression KW - BDNF KW - coronary heart disease KW - heart failure KW - somatic comorbidity KW - acute coronary syndrome Y1 - 2020 U6 - https://doi.org/10.1017/neu.2020.31 SN - 1601-5215 SN - 0924-2708 VL - 33 IS - 1 SP - 22 EP - 30 PB - Cambridge Univ. Press CY - Cambridge ER -