TY  - JOUR
A1  - Kehr, Jan-Christoph
A1  - Picchi, Douglas Gatte
A1  - Dittmann-Thünemann, Elke
T1  - Natural product biosyntheses in cyanobacteria a treasure trove of unique enzymes
JF  - Beilstein journal of organic chemistry
N2  - Cyanobacteria are prolific producers of natural products. Investigations into the biochemistry responsible for the formation of these compounds have revealed fascinating mechanisms that are not, or only rarely, found in other microorganisms. In this article, we survey the biosynthetic pathways of cyanobacteria isolated from freshwater, marine and terrestrial habitats. We especially emphasize modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) pathways and highlight the unique enzyme mechanisms that were elucidated or can be anticipated for the individual products. We further include ribosomal natural products and UV-absorbing pigments from cyanobacteria. Mechanistic insights obtained from the biochemical studies of cyanobacterial pathways can inspire the development of concepts for the design of bioactive compounds by synthetic-biology approaches in the future.
KW  - cyanobacteria
KW  - natural products
KW  - NRPS
KW  - PKS
KW  - ribosomal peptides
Y1  - 2011
U6  - https://doi.org/10.3762/bjoc.7.191
SN  - 1860-5397
VL  - 7
IS  - 2
SP  - 1622
EP  - 1635
PB  - Beilstein-Institut zur Förderung der Chemischen Wissenschaften
CY  - Frankfurt, Main
ER  -