TY  - GEN
A1  - Kaminski, Jakob
A1  - Schlagenhauf, Florian
A1  - Rapp, Michael Armin
A1  - Awasthi, Swapnil
A1  - Ruggeri, Barbara
A1  - Deserno, Lorenz
A1  - Laura, Daedelow
A1  - Banaschewski, Tobias
A1  - Bokde, Arun
A1  - Quinlan, Erin Burke
A1  - Buechel, Christian
A1  - Bromberg, Uli
A1  - Desrivieres, Sylvane
A1  - Flor, Herta
A1  - Frouin, Vincent
A1  - Garavan, Hugh
A1  - Gowland, Penny
A1  - Ittermann, Bernd
A1  - Martinot, Jean-Luc
A1  - Martinot, Marie-Laure Paillere
A1  - Nees, Frauke
A1  - Orfanos, Dimitri Papadopoulos
A1  - Paus, Tomas
A1  - Poustka, Luise
A1  - Smolka, Michael
A1  - Froehner, Juliane
A1  - Walter, Henrik
A1  - Whelan, Robert
A1  - Ripke, Stephan
A1  - Schumann, Gunter
A1  - Heinz, Andreas
T1  - Variance in Dopaminergic Markers
BT  - a possible marker of individual differences in IQ?
T2  - Biological psychiatry : a journal of psychiatric neuroscience and therapeutics ; a publication of the Society of Biological Psychiatry
KW  - Intelligence
KW  - Dopamine
KW  - Epigenetic Biomarkers
KW  - Reward Anticipation
KW  - Polygenic Risk Score
Y1  - 2018
U6  - https://doi.org/10.1016/j.biopsych.2018.02.311
SN  - 0006-3223
SN  - 1873-2402
VL  - 83
IS  - 9
SP  - S118
EP  - S118
PB  - Elsevier
CY  - New York
ER  - 
TY  - JOUR
A1  - Friedel, Eva
A1  - Schlagenhauf, Florian
A1  - Beck, Anne
A1  - Dolan, Raymond J.
A1  - Huys, Quentin J. M.
A1  - Rapp, Michael Armin
A1  - Heinz, Andreas
T1  - The effects of life stress and neural learning signals on fluid intelligence
JF  - European archives of psychiatry and clinical neuroscience : official organ of the German Society for Biological Psychiatry
N2  - Fluid intelligence (fluid IQ), defined as the capacity for rapid problem solving and behavioral adaptation, is known to be modulated by learning and experience. Both stressful life events (SLES) and neural correlates of learning [specifically, a key mediator of adaptive learning in the brain, namely the ventral striatal representation of prediction errors (PE)] have been shown to be associated with individual differences in fluid IQ. Here, we examine the interaction between adaptive learning signals (using a well-characterized probabilistic reversal learning task in combination with fMRI) and SLES on fluid IQ measures. We find that the correlation between ventral striatal BOLD PE and fluid IQ, which we have previously reported, is quantitatively modulated by the amount of reported SLES. Thus, after experiencing adversity, basic neuronal learning signatures appear to align more closely with a general measure of flexible learning (fluid IQ), a finding complementing studies on the effects of acute stress on learning. The results suggest that an understanding of the neurobiological correlates of trait variables like fluid IQ needs to take socioemotional influences such as chronic stress into account.
KW  - Reinforcement learning
KW  - Prediction error signal
KW  - Ventral striatum
KW  - Stress
KW  - Intelligence
Y1  - 2015
U6  - https://doi.org/10.1007/s00406-014-0519-3
SN  - 0940-1334
SN  - 1433-8491
VL  - 265
IS  - 1
SP  - 35
EP  - 43
PB  - Springer
CY  - Heidelberg
ER  -