TY  - JOUR
A1  - Friedrich, Thomas
A1  - Faivre, Lea
A1  - Bäurle-Lenhard, Isabel
A1  - Schubert, Daniel
T1  - Chromatin-based mechanisms of temperature memory in plants
JF  - Plant, cell & environment : cell physiology, whole-plant physiology, community physiology
N2  - For successful growth and development, plants constantly have to gauge their environment. Plants are capable to monitor their current environmental conditions, and they are also able to integrate environmental conditions over time and store the information induced by the cues. In a developmental context, such an environmental memory is used to align developmental transitions with favourable environmental conditions. One temperature-related example of this is the transition to flowering after experiencing winter conditions, that is, vernalization. In the context of adaptation to stress, such an environmental memory is used to improve stress adaptation even when the stress cues are intermittent. A somatic stress memory has now been described for various stresses, including extreme temperatures, drought, and pathogen infection. At the molecular level, such a memory of the environment is often mediated by epigenetic and chromatin modifications. Histone modifications in particular play an important role. In this review, we will discuss and compare different types of temperature memory and the histone modifications, as well as the reader, writer, and eraser proteins involved.
KW  - chromatin
KW  - cold
KW  - epigenetics
KW  - heat
KW  - memory
KW  - nucleosome remodelling
KW  - polycomb
KW  - priming
KW  - trithorax
Y1  - 2018
U6  - https://doi.org/10.1111/pce.13373
SN  - 0140-7791
SN  - 1365-3040
VL  - 42
IS  - 3
SP  - 762
EP  - 770
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Tian, Mei
A1  - Reichetzeder, Christoph
A1  - Li, Jian
A1  - Hocher, Berthold
T1  - Low birth weight, a risk factor for diseases in later life, is a surrogate of insulin resistance at birth
JF  - Journal of hypertension
N2  - Low birth weight (LBW) is associated with diseases in adulthood. The birthweight attributed risk is independent of confounding such as gestational age, sex of the newborn but also social factors. The birthweight attributed risk for diseases in later life holds for the whole spectrum of birthweight. This raises the question what pathophysiological principle is actually behind the association. In this review, we provide evidence that LBW is a surrogate of insulin resistance. Insulin resistance has been identified as a key factor leading to type 2 diabetes, cardiovascular disease as well as kidney diseases. We first provide evidence linking LBW to insulin resistance during intrauterine life. This might be caused by both genetic (genetic variations of genes controlling glucose homeostasis) and/or environmental factors (due to alterations of macronutrition and micronutrition of the mother during pregnancy, but also effects of paternal nutrition prior to conception) leading via epigenetic modifications to early life insulin resistance and alterations of intrauterine growth, as insulin is a growth factor in early life. LBW is rather a surrogate of insulin resistance in early life - either due to inborn genetic or environmental reasons - rather than a player on its own.
KW  - epigenetics
KW  - fetal programing
KW  - genetics
KW  - insulin resistance
KW  - low birth weight
Y1  - 2019
U6  - https://doi.org/10.1097/HJH.0000000000002156
SN  - 0263-6352
SN  - 1473-5598
VL  - 37
IS  - 11
SP  - 2123
EP  - 2134
PB  - Kluwer
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Li, Jian
A1  - Tsuprykov, Oleg
A1  - Yang, Xiaoping
A1  - Hocher, Berthold
T1  - Paternal programming of offspring cardiometabolic diseases in later life
JF  - Journal of hypertension
KW  - cardiometabolic diseases
KW  - epigenetics
KW  - offspring
KW  - paternal programming
KW  - spermatogenesis
KW  - transgenerational effects
Y1  - 2016
U6  - https://doi.org/10.1097/HJH.0000000000001051
SN  - 0263-6352
SN  - 1473-5598
VL  - 34
SP  - 2111
EP  - 2126
PB  - Wiley-Blackwell
CY  - Philadelphia
ER  -