TY  - JOUR
A1  - Woodhouse, Jason Nicholas
A1  - Makower, A. Katharina
A1  - Yeung, Anna C. Y.
A1  - Ongley, Sarah E.
A1  - Micallef, Melinda L.
A1  - Moffitt, Michelle C.
A1  - Neilan, Brett A.
T1  - Advances in genomics, transcriptomics and proteomics of toxin-producing cyanobacteria
JF  - Environmental microbiology reports
N2  - A common misconception persists that the genomes of toxic and non-toxic cyanobacterial strains are largely conserved with the exception of the presence or absence of the genes responsible for toxin production. Implementation of -omics era technologies has challenged this paradigm, with comparative analyses providing increased insight into the differences between strains of the same species. The implementation of genomic, transcriptomic and proteomic approaches has revealed distinct profiles between toxin-producing and non-toxic strains. Further, metagenomics and metaproteomics highlight the genomic potential and functional state of toxic bloom events over time. In this review, we highlight how these technologies have shaped our understanding of the complex relationship between these molecules, their producers and the environment at large within which they persist.
Y1  - 2016
U6  - https://doi.org/10.1111/1758-2229.12366
SN  - 1758-2229
VL  - 8
SP  - 3
EP  - 13
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Neilan, Brett A.
A1  - Pearson, Leanne A.
A1  - Münchhoff, Julia
A1  - Moffitt, Michelle C.
A1  - Dittmann-Thünemann, Elke
T1  - Environmental conditions that influence toxin biosynthesis in cyanobacteria
JF  - Environmental microbiology
N2  - Over the past 15 years, the genetic basis for production of many cyanobacterial bioactive compounds has been described. This knowledge has enabled investigations into the environmental factors that regulate the production of these toxins at the molecular level. Such molecular or systems level studies are also likely to reveal the physiological role of the toxin and contribute to effective water resource management. This review focuses on the environmental regulation of some of the most relevant cyanotoxins, namely the microcystins, nodularin, cylindrospermopsin, saxitoxins, anatoxins and jamaicamides.
Y1  - 2013
U6  - https://doi.org/10.1111/j.1462-2920.2012.02729.x
SN  - 1462-2912
VL  - 15
IS  - 5
SP  - 1239
EP  - 1253
PB  - Wiley-Blackwell
CY  - Hoboken
ER  -