TY  - JOUR
A1  - Behl, Marc
A1  - Razzaq, Muhammad Yasar
A1  - Mazurek-Budzynska, Magdalena
A1  - Lendlein, Andreas
T1  - Polyetheresterurethane based porous scaffolds with tailorable architectures by supercritical CO2 foaming
JF  - MRS advances
N2  - Porous three-dimensional (3D) scaffolds are promising treatment options in regenerative medicine. Supercritical and dense-phase fluid technologies provide an attractive alternative to solvent-based scaffold fabrication methods. In this work, we report on the fabrication of poly-etheresterurethane (PPDO-PCL) based porous scaffolds with tailorable pore size, porosity, and pore interconnectivity by using supercritical CO2(scCO(2)) fluid-foaming. The influence of the processing parameters such as soaking time, soaking temperature and depressurization on porosity, pore size, and interconnectivity of the foams were investigated. The average pore diameter could be varied between 100-800 mu m along with a porosity in the range from (19 +/- 3 to 61 +/- 6)% and interconnectivity of up to 82%. To demonstrate their applicability as scaffold materials, selected foams were sterilized via ethylene oxide sterilization. They showed negligible cytotoxicity in tests according to DIN EN ISO 10993-5 and 10993-12 using L929 cells. The study demonstrated that the pore size, porosity and the interconnectivity of this multi-phase semicrystalline polymer could be tailored by careful control of the processing parameters during the scCO(2)foaming process. In this way, PPDO-PCL scaffolds with high porosity and interconnectivity are potential candidate materials for regenerative treatment options.
Y1  - 2020
U6  - https://doi.org/10.1557/adv.2020.345
SN  - 2059-8521
VL  - 5
IS  - 45
SP  - 2317
EP  - 2330
PB  - Cambridge University Press
CY  - New York, NY
ER  -