TY  - JOUR
A1  - Hentrich, Doreen
A1  - Tauer, Klaus
A1  - Espanol, Montserrat
A1  - Ginebra, Maria-Pau
A1  - Taubert, Andreas
T1  - EDTA and NTA effectively tune the mineralization of calcium phosphate from bulk aqueous solution
JF  - Biomimetics
N2  - This study describes the effects of nitrilotriacetic acid (NTA) and ethylenediaminotetraacetic acid (EDTA) on themineralization of calciumphosphate from bulk aqueous solution. Mineralization was performed between pH 6 and 9 and with NTA or EDTA concentrations of 0, 5, 10, and 15 mM. X-ray diffraction and infrared spectroscopy show that at low pH, mainly brushite precipitates and at higher pH, mostly hydroxyapatite forms. Both additives alter the morphology of the precipitates. Without additive, brushite precipitates as large plates. With NTA, the morphology changes to an unusual rod-like shape. With EDTA, the edges of the particles are rounded and disk-like particles form. Conductivity and pH measurements suggest that the final products form through several intermediate steps.
KW  - biomineralization
KW  - biomimetic mineralization
KW  - calcium phosphate
KW  - NTA
KW  - EDTA
KW  - precipitation
KW  - brushite
KW  - hydroxyapatite
Y1  - 2017
U6  - https://doi.org/10.3390/biomimetics2040024
SN  - 2313-7673
VL  - 2
IS  - 4
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Mai, Tobias
A1  - Wolski, Karol
A1  - Puciul-Malinowska, Agnieszka
A1  - Kopyshev, Alexey
A1  - Gräf, Ralph
A1  - Bruns, Michael
A1  - Zapotoczny, Szczepan
A1  - Taubert, Andreas
T1  - Anionic polymer brushes for biomimetic calcium phosphate mineralization
BT  - A surface with application potential in biomaterials
JF  - Polymers
N2  - This article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained via surface-initiated atom transfer radical polymerization. Mineralization with doubly concentrated simulated body fluid yields polymer/inorganic hybrid films containing AB-Type carbonated hydroxyapatite (CHAP), a material resembling the inorganic component of bone. Moreover, growth experiments using Dictyostelium discoideum amoebae demonstrate that the mineral-free and the mineral-containing polymer brushes have a good biocompatibility suggesting their use as biocompatible surfaces in implantology or related fields.
KW  - polymer brushes
KW  - calcium phosphate
KW  - hydroxyapatite
KW  - carbonated apatite
KW  - bone mimic
KW  - biocompatibility
KW  - Dictyostelium discoideum
Y1  - 2018
U6  - https://doi.org/10.3390/polym10101165
SN  - 2073-4360
VL  - 10
IS  - 10
PB  - MDPI
CY  - Basel
ER  -