TY - GEN A1 - Wippert, Pia-Maria A1 - Wiebking, Christine T1 - Stress and Alterations in the Pain Matrix BT - A Biopsychosocial Perspective on Back Pain and Its Prevention and Treatment T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - The genesis of chronic pain is explained by a biopsychosocial model. It hypothesizes an interdependency between environmental and genetic factors provoking aberrant long-term changes in biological and psychological regulatory systems. Physiological effects of psychological and physical stressors may play a crucial role in these maladaptive processes. Specifically, long-term demands on the stress response system may moderate central pain processing and influence descending serotonergic and noradrenergic signals from the brainstem, regulating nociceptive processing at the spinal level. However, the underlying mechanisms of this pathophysiological interplay still remain unclear. This paper aims to shed light on possible pathways between physical (exercise) and psychological stress and the potential neurobiological consequences in the genesis and treatment of chronic pain, highlighting evolving concepts and promising research directions in the treatment of chronic pain. Two treatment forms (exercise and mindfulness-based stress reduction as exemplary therapies), their interaction, and the dose-response will be discussed in more detail, which might pave the way to a better understanding of alterations in the pain matrix and help to develop future prevention and therapeutic concepts T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 438 KW - stress KW - allostatic load KW - relaxation KW - back pain KW - chronic pain KW - physical activity KW - exercise KW - neuroplasticity KW - pain matrix Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-412058 IS - 438 ER - TY - JOUR A1 - Wippert, Pia-Maria A1 - Wiebking, Christine T1 - Stress and Alterations in the Pain Matrix BT - A Biopsychosocial Perspective on Back Pain and Its Prevention and Treatment JF - International Journal of Environmental Research and Public Health N2 - The genesis of chronic pain is explained by a biopsychosocial model. It hypothesizes an interdependency between environmental and genetic factors provoking aberrant long-term changes in biological and psychological regulatory systems. Physiological effects of psychological and physical stressors may play a crucial role in these maladaptive processes. Specifically, long-term demands on the stress response system may moderate central pain processing and influence descending serotonergic and noradrenergic signals from the brainstem, regulating nociceptive processing at the spinal level. However, the underlying mechanisms of this pathophysiological interplay still remain unclear. This paper aims to shed light on possible pathways between physical (exercise) and psychological stress and the potential neurobiological consequences in the genesis and treatment of chronic pain, highlighting evolving concepts and promising research directions in the treatment of chronic pain. Two treatment forms (exercise and mindfulness-based stress reduction as exemplary therapies), their interaction, and the dose-response will be discussed in more detail, which might pave the way to a better understanding of alterations in the pain matrix and help to develop future prevention and therapeutic concepts KW - stress KW - allostatic load KW - relaxation KW - back pain KW - chronic pain KW - physical activity KW - exercise KW - neuroplasticity KW - pain matrix Y1 - 2018 U6 - https://doi.org/10.3390/ijerph15040785 SN - 1660-4601 SN - 1661-7827 VL - 15 IS - 4 SP - 1 EP - 11 PB - MDPI AG CY - Basel ER - TY - GEN A1 - He, Yangyang A1 - Wuertz-Kozak, Karin A1 - Kuehl, Linn K. A1 - Wippert, Pia-Maria T1 - Extracellular vesicles: potential mediators of psychosocial stress contribution to osteoporosis? T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Osteoporosis is characterized by low bone mass and damage to the bone tissue’s microarchitecture, leading to increased fracture risk. Several studies have provided evidence for associations between psychosocial stress and osteoporosis through various pathways, including the hypothalamic-pituitary-adrenocortical axis, the sympathetic nervous system, and other endocrine factors. As psychosocial stress provokes oxidative cellular stress with consequences for mitochondrial function and cell signaling (e.g., gene expression, inflammation), it is of interest whether extracellular vesicles (EVs) may be a relevant biomarker in this context or act by transporting substances. EVs are intercellular communicators, transfer substances encapsulated in them, modify the phenotype and function of target cells, mediate cell-cell communication, and, therefore, have critical applications in disease progression and clinical diagnosis and therapy. This review summarizes the characteristics of EVs, their role in stress and osteoporosis, and their benefit as biological markers. We demonstrate that EVs are potential mediators of psychosocial stress and osteoporosis and may be beneficial in innovative research settings. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1166 KW - allostatic load KW - bone remodeling KW - microRNA KW - osteoblast KW - osteoclast Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-523007 SN - 1866-8372 IS - 11 ER - TY - JOUR A1 - He, Yangyang A1 - Würtz-Kozak, Karin A1 - Kühl, Linn Kristina A1 - Wippert, Pia-Maria T1 - Extracellular vesicles BT - Potential mediators of psychosocial stress contribution to osteoporosis? JF - International journal of molecular sciences N2 - Osteoporosis is characterized by low bone mass and damage to the bone tissue’s microarchitecture, leading to increased fracture risk. Several studies have provided evidence for associations between psychosocial stress and osteoporosis through various pathways, including the hypothalamic-pituitary-adrenocortical axis, the sympathetic nervous system, and other endocrine factors. As psychosocial stress provokes oxidative cellular stress with consequences for mitochondrial function and cell signaling (e.g., gene expression, inflammation), it is of interest whether extracellular vesicles (EVs) may be a relevant biomarker in this context or act by transporting substances. EVs are intercellular communicators, transfer substances encapsulated in them, modify the phenotype and function of target cells, mediate cell-cell communication, and, therefore, have critical applications in disease progression and clinical diagnosis and therapy. This review summarizes the characteristics of EVs, their role in stress and osteoporosis, and their benefit as biological markers. We demonstrate that EVs are potential mediators of psychosocial stress and osteoporosis and may be beneficial in innovative research settings. KW - allostatic load KW - bone remodeling KW - microRNA KW - osteoblast KW - osteoclast Y1 - 2021 U6 - https://doi.org/10.3390/ijms22115846 SN - 1422-0067 VL - 22 IS - 11 PB - Molecular Diversity Preservation International CY - Basel ER - TY - JOUR A1 - Osei, Francis A1 - Block, Andrea A1 - Wippert, Pia-Maria T1 - Association of primary allostatic load mediators and metabolic syndrome (MetS): A systematic review JF - Frontiers in Endocrinology N2 - Allostatic load (AL) exposure may cause detrimental effects on the neuroendocrine system, leading to metabolic syndrome (MetS). The primary mediators of AL involve serum dehydroepiandrosterone sulfate (DHEAS; a functional HPA axis antagonist); further, cortisol, urinary norepinephrine (NE), and epinephrine (EPI) excretion levels (assessed within 12-h urine as a golden standard for the evaluation of the HPA axis activity and sympathetic nervous system activity). However, the evidence of an association between the primary mediators of AL and MetS is limited. This systematic review aimed to critically examine the association between the primary mediators of AL and MetS. PubMed and Web of Science were searched for articles from January 2010 to December 2021, published in English. The search strategy focused on cross-sectional and case–control studies comprising adult participants with MetS, obesity, overweight, and without chronic diseases. The STROBE checklist was used to assess study quality control. Of 770 studies, twenty-one studies with a total sample size (n = 10,666) met the eligibility criteria. Eighteen studies were cross-sectional, and three were case–control studies. The included studies had a completeness of reporting score of COR % = 87.0 ± 6.4%. It is to be noted, that cortisol as a primary mediator of AL showed an association with MetS in 50% (urinary cortisol), 40% (serum cortisol), 60% (salivary cortisol), and 100% (hair cortisol) of the studies. For DHEAS, it is to conclude that 60% of the studies showed an association with MetS. In contrast, urinary EPI and urinary NE had 100% no association with MetS. In summary, there is a tendency for the association between higher serum cortisol, salivary cortisol, urinary cortisol, hair cortisol, and lower levels of DHEAS with MetS. Future studies focusing on longitudinal data are warranted for clarification and understanding of the association between the primary mediators of AL and MetS. KW - allostatic load KW - cortisol KW - dehydroepiandrosterone sulfate KW - epinephrine KW - norepinephrine KW - metabolic syndrome KW - primary marker Y1 - 2022 U6 - https://doi.org/10.3389/fendo.2022.946740 SN - 1664-2392 VL - 13 PB - Frontiers CY - Lausanne, Schweiz ER - TY - GEN A1 - Osei, Francis A1 - Block, Andrea A1 - Wippert, Pia-Maria T1 - Association of primary allostatic load mediators and metabolic syndrome (MetS): A systematic review T2 - Zweitveröffentlichungen der Universität Potsdam : Gesundheitswissenschaftliche Reihe N2 - Allostatic load (AL) exposure may cause detrimental effects on the neuroendocrine system, leading to metabolic syndrome (MetS). The primary mediators of AL involve serum dehydroepiandrosterone sulfate (DHEAS; a functional HPA axis antagonist); further, cortisol, urinary norepinephrine (NE), and epinephrine (EPI) excretion levels (assessed within 12-h urine as a golden standard for the evaluation of the HPA axis activity and sympathetic nervous system activity). However, the evidence of an association between the primary mediators of AL and MetS is limited. This systematic review aimed to critically examine the association between the primary mediators of AL and MetS. PubMed and Web of Science were searched for articles from January 2010 to December 2021, published in English. The search strategy focused on cross-sectional and case–control studies comprising adult participants with MetS, obesity, overweight, and without chronic diseases. The STROBE checklist was used to assess study quality control. Of 770 studies, twenty-one studies with a total sample size (n = 10,666) met the eligibility criteria. Eighteen studies were cross-sectional, and three were case–control studies. The included studies had a completeness of reporting score of COR % = 87.0 ± 6.4%. It is to be noted, that cortisol as a primary mediator of AL showed an association with MetS in 50% (urinary cortisol), 40% (serum cortisol), 60% (salivary cortisol), and 100% (hair cortisol) of the studies. For DHEAS, it is to conclude that 60% of the studies showed an association with MetS. In contrast, urinary EPI and urinary NE had 100% no association with MetS. In summary, there is a tendency for the association between higher serum cortisol, salivary cortisol, urinary cortisol, hair cortisol, and lower levels of DHEAS with MetS. Future studies focusing on longitudinal data are warranted for clarification and understanding of the association between the primary mediators of AL and MetS. T3 - Zweitveröffentlichungen der Universität Potsdam : Gesundheitswissenschaftliche Reihe - 6 KW - allostatic load KW - cortisol KW - dehydroepiandrosterone sulfate KW - epinephrine KW - norepinephrine KW - metabolic syndrome KW - primary marker Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-581769 IS - 6 ER - TY - THES A1 - He, Yangyang T1 - Extracellular vesicles as the potential mediators of psychosocial stress contribution to osteoporosis T1 - Extrazelluläre Vesikel als potenzielle Mediatoren für den Beitrag von psychosozialem Stress zur Osteoporose BT - a narrative review BT - ein narrativer Überblick N2 - Background: The characteristics of osteoporosis are decreased bone mass and destruction towards the microarchitecture of bone tissue, which raises the risk of fracture. Psychosocialstress and osteoporosis are linked by sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and other endocrine factors. Psychosocial stress causes a series of effects on the organism, and this long-term depletion at the cellular level is considered to be mitochondrial allostatic load, including mitochondrial dysfunction and oxidative stress. Extracellular vesicles (EVs) are involved in the mitochondrial allostatic load process and may as biomarkers in this setting. As critical participants during cell-to-cell communications, EVs serve as transport vehicles for nucleic acid and proteins, alter the phenotypic and functional characteristics of their target cells, and promote cell-to-cell contact. And hence, they play a significant role in the diagnosis and therapy of many diseases, such as osteoporosis. Aim: This narrative review attempts to outline the features of EVs, investigate their involvement in both psychosocial stress and osteoporosis, and analyze if EVs can be potential mediators between both. Methods: The online database from PubMed, Google Scholar, and Science Direct were searched for keywords related to the main topic of this study, and the availability of all the selected studies was verified. Afterward, the findings from the articles were summarized and synthesized. Results: Psychosocial stress affects bone remodeling through increased neurotransmitters such as glucocorticoids and catecholamines, as well as increased glucose metabolism. Furthermore, psychosocial stress leads to mitochondrial allostatic load, including oxidative stress, which may affect bone remodeling. In vitro and in vivo data suggest EVs might involve in the link between psychosocial stress and bone remodeling through the transfer of bioactive substances and thus be a potential mediator of psychosocial stress leading to osteoporosis. Conclusions: According to the included studies, psychosocial stress affects bone remodeling, leading to osteoporosis. By summarizing the specific properties of EVs and the function of EVs in both psychosocial stress and osteoporosis, respectively, it has been demonstrated that EVs are possible mediators of both, and have the prospects to be useful in innovative research areas. N2 - Hintergrund: Kennzeichnend für Osteoporose sind eine verringerte Knochenmasse und die Zerstörung der Mikroarchitektur des Knochengewebes, wodurch sich das Risiko von Knochenbrüchen erhöht. Psychosozialer Stress und Osteoporose sind durch das sympathische Nervensystem, die Hypothalamus-Hypophysen-Nebennieren-Achse und andere endokrine Faktoren miteinander verbunden. Psychosozialer Stress hat eine Reihe von Auswirkungen auf den Organismus, und diese langfristige Erschöpfung auf zellulärer Ebene wird als mitochondriale allostatische Belastung angesehen, die eine mitochondriale Dysfunktion und oxidativen Stress beinhaltet. Extrazelluläre Vesikel (EVs) sind in den mitochondrialen allostatischen Belastungsprozess involviert und können in diesem Zusammenhang als Biomarker dienen. Als kritische Teilnehmer der Zell-zu-Zell-Kommunikation dienen EVs als Transportmittel für Nukleinsäuren und Proteine, verändern die phänotypischen und funktionellen Eigenschaften ihrer Zielzellen und fördern den Zell-zu-Zell-Kontakt. Daher spielen sie eine wichtige Rolle bei der Diagnose und Therapie vieler Krankheiten, wie z. B. Osteoporose. Ziel: Diese Übersichtsarbeit soll die Eigenschaften von EVs und ihre Rolle in Hinblick auf den Zusammenhang zwischen psychosozialen Stress und Osteoporose zusammenfassen. Weiterhin wird untersucht, ob EVs in dem Zusammenhang eine potenzielle Mediatorenrolle zukommt. Methoden Die Online-Datenbanken PubMed, Google Scholar und Science Direct wurden anhand thematischer Stichwörter durchsucht und die Verfügbarkeit aller ausgewählten Studien überprüft. Anschließend wurden die Ergebnisse der Artikel zusammengefasst und miteinander in Verbindung setzen. Ergebnisse: Psychosozialer Stress führt zu einer Erhöhung der Transmitterkonzentrate wie Glukokortikoide und Katecholamine sowie einen erhöhten Glukosestoffwechsel, was jeweils Einfluss auf den Knochenumbau haben kann. Darüber hinaus führt psychosozialer Stress zu mitochondrialer allostatischer Last, einschließlich oxidativem Stress, was sich ebenfalls auf den Knochenumbau auswirken kann. Sowohl in vitro- als auch in vivo-Daten deuten darauf hin, dass EVs hierbei durch ihre Übertragung von bioaktiven Messengern eine relevante Mediatorenrolle einnehmen. Es ist anzunehmen, dass sie potenzielle Vermittler des Zusammenhangs von psychosozialem Stress und osteoporotischen Veränderungen sein können. Schlussfolgerung: Entlang der eingeschlossenen Studien besteht ein Zusammenhang zwischen psychosozialem Stress, dem Knochenumbau und damit der Entstehung von Osteoporose. In der Genese des negativen Einflusses auf die Knochengesundheit scheint EVs durch ihre Aktivität als Messenger-Transporter eine relevante Mediatorenrolle zuzukommen. Dieses Wissen hat das Potenzial für zukünftige innovative Forschungskonzepte. KW - allostatic load KW - allostatische Belastung KW - bone remodeling KW - microRNA KW - osteoblast KW - osteoclast KW - Knochenumbau KW - microRNA KW - Osteoblast KW - Osteoklast Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-594372 ER -