TY  - GEN
A1  - Steinfath, Matthias
A1  - Gärtner, Tanja
A1  - Lisec, Jan
A1  - Meyer, Rhonda C.
A1  - Altmann, Thomas
A1  - Willmitzer, Lothar
A1  - Selbig, Joachim
T1  - Prediction of hybrid biomass in Arabidopsis thaliana by selected parental SNP and metabolic markers
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - A recombinant inbred line (RIL) population, derived from two Arabidopsis thaliana accessions, and the corresponding testcrosses with these two original accessions were used for the development and validation of machine learning models to predict the biomass of hybrids. Genetic and metabolic information of the RILs served as predictors. Feature selection reduced the number of variables (genetic and metabolic markers) in the models by more than 80% without impairing the predictive power. Thus, potential biomarkers have been revealed. Metabolites were shown to bear information on inherited macroscopic phenotypes. This proof of concept could be interesting for breeders. The example population exhibits substantial mid-parent biomass heterosis. The results of feature selection could therefore be used to shed light on the origin of heterosis. In this respect, mainly dominance effects were detected.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1324 
KW  - Quantitative Trait Locus
KW  - feature selection
KW  - Partial Little Square
KW  - recombinant inbred line
KW  - Quantitative Trait Locus analysis
Y1  - 2009
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431115
SN  - 1866-8372
IS  - 1324
ER  - 
TY  - JOUR
A1  - Meyer, Rhonda Christiane
A1  - Kusterer, Barbara
A1  - Lisec, Jan
A1  - Steinfath, Matthias
A1  - Becher, Martina
A1  - Scharr, Hanno
A1  - Melchinger, Albrecht E.
A1  - Selbig, Joachim
A1  - Schurr, Ulrich
A1  - Willmitzer, Lothar
A1  - Altmann, Thomas
T1  - QTL analysis of early stage heterosis for biomass in Arabidopsis
JF  - Theoretical and applied genetics
N2  - The main objective of this study was to identify genomic regions involved in biomass heterosis using QTL, generation means, and mode-of-inheritance classification analyses. In a modified North Carolina Design III we backcrossed 429 recombinant inbred line and 140 introgression line populations to the two parental accessions, C24 and Col-0, whose F 1 hybrid exhibited 44% heterosis for biomass. Mid-parent heterosis in the RILs ranged from −31 to 99% for dry weight and from −58 to 143% for leaf area. We detected ten genomic positions involved in biomass heterosis at an early developmental stage, individually explaining between 2.4 and 15.7% of the phenotypic variation. While overdominant gene action was prevalent in heterotic QTL, our results suggest that a combination of dominance, overdominance and epistasis is involved in biomass heterosis in this Arabidopsis cross.
KW  - Quantitative Trait Locus
KW  - recombinant inbred line
KW  - Quantitative Trait Locus analysis
KW  - dominance effect
KW  - recombinant inbred line population
Y1  - 2009
U6  - https://doi.org/10.1007/s00122-009-1074-6
SN  - 1432-2242
SN  - 0040-5752
VL  - 129
IS  - 2
SP  - 227
EP  - 237
PB  - Springer Nature
CY  - Berlin
ER  - 
TY  - GEN
A1  - Meyer, Rhonda Christiane
A1  - Kusterer, Barbara
A1  - Lisec, Jan
A1  - Steinfath, Matthias
A1  - Becher, Martina
A1  - Scharr, Hanno
A1  - Melchinger, Albrecht E.
A1  - Selbig, Joachim
A1  - Schurr, Ulrich
A1  - Willmitzer, Lothar
A1  - Altmann, Thomas
T1  - QTL analysis of early stage heterosis for biomass in Arabidopsis
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - The main objective of this study was to identify genomic regions involved in biomass heterosis using QTL, generation means, and mode-of-inheritance classification analyses. In a modified North Carolina Design III we backcrossed 429 recombinant inbred line and 140 introgression line populations to the two parental accessions, C24 and Col-0, whose F 1 hybrid exhibited 44% heterosis for biomass. Mid-parent heterosis in the RILs ranged from −31 to 99% for dry weight and from −58 to 143% for leaf area. We detected ten genomic positions involved in biomass heterosis at an early developmental stage, individually explaining between 2.4 and 15.7% of the phenotypic variation. While overdominant gene action was prevalent in heterotic QTL, our results suggest that a combination of dominance, overdominance and epistasis is involved in biomass heterosis in this Arabidopsis cross.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1330 
KW  - Quantitative Trait Locus
KW  - recombinant inbred line
KW  - Quantitative Trait Locus analysis
KW  - dominance effect
KW  - recombinant inbred line population
Y1  - 2009
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431272
SN  - 1866-8372
IS  - 1330
ER  - 
TY  - JOUR
A1  - Steinfath, Matthias
A1  - Gärtner, Tanja
A1  - Lisec, Jan
A1  - Meyer, Rhonda Christiane
A1  - Altmann, Thomas
A1  - Willmitzer, Lothar
A1  - Selbig, Joachim
T1  - Prediction of hybrid biomass in Arabidopsis thaliana by selected parental SNP and metabolic markers
JF  - Theoretical and applied genetics : TAG ; international journal of plant breeding research
N2  - A recombinant inbred line (RIL) population, derived from two Arabidopsis thaliana accessions, and the corresponding testcrosses with these two original accessions were used for the development and validation of machine learning models to predict the biomass of hybrids. Genetic and metabolic information of the RILs served as predictors. Feature selection reduced the number of variables (genetic and metabolic markers) in the models by more than 80% without impairing the predictive power. Thus, potential biomarkers have been revealed. Metabolites were shown to bear information on inherited macroscopic phenotypes. This proof of concept could be interesting for breeders. The example population exhibits substantial mid-parent biomass heterosis. The results of feature selection could therefore be used to shed light on the origin of heterosis. In this respect, mainly dominance effects were detected.
KW  - Quantitative Trait Locus
KW  - feature selection
KW  - Partial Little Square
KW  - recombinant inbred line
KW  - Quantitative Trait Locus analysis
Y1  - 2009
U6  - https://doi.org/10.1007/s00122-009-1191-2
SN  - 0040-5752
SN  - 1432-2242
VL  - 120
SP  - 239
EP  - 247
PB  - Springer
CY  - Berlin
ER  -