TY  - JOUR
A1  - Mai, Tobias
A1  - Wolski, Karol
A1  - Puciul-Malinowska, Agnieszka
A1  - Kopyshev, Alexey
A1  - Gräf, Ralph
A1  - Bruns, Michael
A1  - Zapotoczny, Szczepan
A1  - Taubert, Andreas
T1  - Anionic polymer brushes for biomimetic calcium phosphate mineralization
BT  - A surface with application potential in biomaterials
JF  - Polymers
N2  - This article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained via surface-initiated atom transfer radical polymerization. Mineralization with doubly concentrated simulated body fluid yields polymer/inorganic hybrid films containing AB-Type carbonated hydroxyapatite (CHAP), a material resembling the inorganic component of bone. Moreover, growth experiments using Dictyostelium discoideum amoebae demonstrate that the mineral-free and the mineral-containing polymer brushes have a good biocompatibility suggesting their use as biocompatible surfaces in implantology or related fields.
KW  - polymer brushes
KW  - calcium phosphate
KW  - hydroxyapatite
KW  - carbonated apatite
KW  - bone mimic
KW  - biocompatibility
KW  - Dictyostelium discoideum
Y1  - 2018
U6  - https://doi.org/10.3390/polym10101165
SN  - 2073-4360
VL  - 10
IS  - 10
PB  - MDPI
CY  - Basel
ER  -