TY  - JOUR
A1  - Dissmann, R.
A1  - Cromme, L. J.
A1  - Salzwedel, Annett
A1  - Taborski, U.
A1  - Kunath, J.
A1  - Gaebler, F.
A1  - Heyne, K.
A1  - Völler, Heinz
T1  - Computer aided dosage management of phenprocoumon anticoagulation therapy Clinical validation
JF  - Hämostaseologie : Organ der Gesellschaft für Thrombose- und Hämostaseforschung e.V. (GTH)
N2  - A recently developed multiparameter computer-aided expert system (TheMa) for guiding anticoagulation with phenprocoumon (PPC) was validated by a prospective investigation in 22 patients. The PPC-INR-response curve resulting from physician guided dosage was compared to INR values calculated by "twin calculation" from TheMa recommended dosage. Additionally, TheMa was used to predict the optimal time to perform surgery or invasive procedures after interruption of anticogulation therapy. Results: Comparison of physician and TheMa guided anticoagulation showed almost identical accuracy by three quantitative measures: Polygon integration method (area around INR target) 616.17 vs. 607.86, INR hits in the target range 166 vs. 161, and TTR (time in therapeutic range) 63.91 vs. 62.40 %. After discontinuation of anticoagulation therapy, calculating the INR phase-out curve with TheMa INR prognosis of 1.8 was possible with a standard deviation of 0.50 +/- 0.59 days. Conclusion: Guiding anticoagulation with TheMa was as accurate as Physician guided therapy. After interruption of anticoagulant therapy, TheMa may be used for calculating the optimal time performing operations or initiating bridging therapy.
KW  - Oral anticoagulation therapy
KW  - warfarin
KW  - phenprocoumon
KW  - computer aided dosage
KW  - expert system
Y1  - 2014
U6  - https://doi.org/10.5482/HAMO-13-06-0030
SN  - 0720-9355
VL  - 34
IS  - 3
SP  - 226
EP  - 232
PB  - Schattauer
CY  - Stuttgart
ER  -