TY  - JOUR
A1  - Beijersbergen, Chantal M. I.
A1  - Granacher, Urs
A1  - Gaebler, Martijn
A1  - DeVita, Paul
A1  - Hortobagyi, Tibor
T1  - Hip mechanics underlie lower extremity power training-induced increase  in old adults’ fast gait velocity
BT  - the Potsdam Gait Study (POGS)
JF  - Gait & posture
N2  - Methods: As part of the Potsdam Gait Study (POGS), healthy old adults completed a no-intervention control period (69.1 +/- 4A yrs, n =14) or a power training program followed by detraining (72.9 +/- 5.4 yrs, n = 15).We measured isokinetic knee extensor and plantarflexor power and measured hip, knee and ankle kinetics at habitual, fast and standardized walking speeds. Results: Power training significantly increased isokinetic knee extensor power (25%), plantarflexor power (43%), and fast gait velocity (5.9%). Gait mechanics underlying the improved fast gait velocity included increases in hip angular impulse (29%) and H1 work (37%) and no changes in positive knee (K2) and A2 work. Detraining further improved fast gait velocity (4.7%) with reductions in H1(-35%), and increases in K2 (36%) and A2 (7%). Conclusion: Power training increased fast gait velocity in healthy old adults by increasing the reliance on hip muscle function and thus further strengthened the age-related distal-to-proximal shift in muscle function. (C) 2016 Elsevier B.V. All rights reserved.
KW  - Walking
KW  - Biomechanics
KW  - Detraining
KW  - Muscle
KW  - Exercise
Y1  - 2017
U6  - https://doi.org/10.1016/j.gaitpost.2016.12.024
SN  - 0966-6362
SN  - 1879-2219
VL  - 52
SP  - 338
EP  - 344
PB  - Elsevier
CY  - Clare
ER  - 
TY  - JOUR
A1  - Thiem, A.
A1  - Bagheri, M.
A1  - Grosse-Siestrup, C.
A1  - Zehbe, Rolf
T1  - Gelatin-poly(lactic-co-glycolic acid) scaffolds with oriented pore channel architecture - From in vitro to in vivo testing
JF  - Vision research : an international journal for functional aspects of vision.
N2  - A gelatin-poly(lactic-co-glycolic acid), PLGA, composite scaffold, featuring a highly oriented pore channel structure, was developed as a template for articular cartilage regeneration. As a design principle the composite scaffold was optimized to contain only medical grade educts and accordingly no chemical cross linking agents or other toxicological relevant substances or methods were used. Scaffolds were synthesized using a freeze structuring method combined with an electrochemical process followed by freeze-drying. Finally, cross linking was performed using dehydrothermal treatment, which was simultaneously used for sterilization purposes. These composite scaffolds were analyzed in regard to structural and biomechanical properties, and to their degradation behavior. Furthermore, cell culture performance was tested using chondrocytes originated from joint articular cartilage tissue from 6 to 10 months old domestic pigs. Finally, the scaffolds were tested for tissue biocompatibility and their ability for tissue integration in a rat model. The scaffolds showed both excellent functional performance and high biocompatibility in vitro and in vivo. We expect that these gelatin-PLGA scaffolds can effectively support chondrogenesis in vivo demonstrating great potential for the use in cartilage defect treatment. (C) 2016 Elsevier B.V. All rights reserved.
KW  - Gelatin-PLGA Scaffold
KW  - Dehydrothermal cross linking
KW  - Cartilage tissue engineering
KW  - Biomechanics
KW  - Rat model
Y1  - 2016
U6  - https://doi.org/10.1016/j.msec.2016.02.019
SN  - 0928-4931
SN  - 1873-0191
VL  - 62
SP  - 585
EP  - 595
PB  - Elsevier
CY  - Amsterdam
ER  -