TY  - JOUR
A1  - Li, Zhengdong
A1  - Xu, Xun
A1  - Wang, Weiwei
A1  - Kratz, Karl
A1  - Sun, Xianlei
A1  - Zou, Jie
A1  - Deng, Zijun
A1  - Jung, Friedrich Wilhelm
A1  - Gossen, Manfred
A1  - Ma, Nan
A1  - Lendlein, Andreas
T1  - Modulation of the mesenchymal stem cell migration capacity via preconditioning with topographic microstructure
JF  - Clinical hemorheology and microcirculation : blood flow and vessels
N2  - Controlling mesenchymal stem cells (MSCs) behavior is necessary to fully exploit their therapeutic potential. Various approaches are employed to effectively influence the migration capacity of MSCs. Here, topographic microstructures with different microscale roughness were created on polystyrene (PS) culture vessel surfaces as a feasible physical preconditioning strategy to modulate MSC migration. By analyzing trajectories of cells migrating after reseeding, we demonstrated that the mobilization velocity of human adipose derived mesenchymal stem cells (hADSCs) could be promoted by and persisted after brief preconditioning with the appropriate microtopography. Moreover, the elevated activation levels of focal adhesion kinase (FAK) and mitogen-activated protein kinase (MAPK) in hADSCs were also observed during and after the preconditioning process. These findings underline the potential enhancement of in vivo therapeutic efficacy in regenerative medicine via transplantation of topographic microstructure preconditioned stem cells.
KW  - Mesenchymal stem cells
KW  - precondition
KW  - microstructure
KW  - migration
KW  - FAK-MAPK
Y1  - 2017
U6  - https://doi.org/10.3233/CH-179208
SN  - 1386-0291
SN  - 1875-8622
VL  - 67
SP  - 267
EP  - 278
PB  - IOS Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Sauter, Tilman
A1  - Kratz, Karl
A1  - Lendlein, Andreas
T1  - Pore-size distribution controls shape-memory properties on the macro- and microscale of polymeric foams
JF  - Macromolecular chemistry and physics
N2  - Open porous foams with identical foam density but different pore-size distributions (bimodal or monomodal) are prepared from a shape-memory polyetherurethane (PEU) by thermally induced phase separation. The shape-memory effect of the two PEU foams is explored by cyclic thermomechanical compression tests and microstructural analysis. The obtained results reveal that the PEU foam with a bimodal pore-size distribution exhibits an increased shape-recovery under stress-free conditions, both on the macro- (foam level) as well as the microscale (pore level). While bimodal pore-size distributions induce microscale bending during compression, buckling occurs in foams with monomodal pore-size distributions, leading to both a reduced and delayed shape recovery.
KW  - microstructure
KW  - morphology
KW  - polymer foams
KW  - pore-size distribution
KW  - shape-memory polymers
Y1  - 2013
U6  - https://doi.org/10.1002/macp.201300062
SN  - 1022-1352
VL  - 214
IS  - 11
SP  - 1184
EP  - 1188
PB  - Wiley-VCH
CY  - Weinheim
ER  -