TY  - RPRT
A1  - Caliendo, Marco
A1  - Mahlstedt, Robert
A1  - van den Berg, Gerard J.
A1  - Vikström, Johan
T1  - Side Effects of Labor Market Policies
T2  - CEPA Discussion Papers
N2  - Labor market policy tools such as training and sanctions are commonly used to help bring workers back to work. By analogy to medical treatments, the individual exposure to these tools may have side effects. We study effects on health using individual-level population registers on labor market events outcomes, drug prescriptions and sickness absence, comparing outcomes before and after exposure to training and sanctions. We find that training improves cardiovascular and mental health and lowers sickness absence. The results suggest that this is not due to improved employment prospects but rather to instantaneous features of participation such as, perhaps, the adoption of a more rigorous daily routine. Unemployment benefits sanctions cause a short-run deterioration of mental health, possibly due higher stress levels, but this tapers out quickly.
T3  - CEPA Discussion Papers - 22 
KW  - unemployment
KW  - health
KW  - sickness
KW  - prescriptions
KW  - mental health
KW  - drugs
KW  - training
KW  - depression
KW  - cardiovascular disease
KW  - sanctions
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-478839
SN  - 2628-653X
IS  - 22
ER  - 
TY  - THES
A1  - Pérez Chaparro, Camilo Germán Alberto
T1  - Non-HIV comorbidities and exercise in German people living with HIV
T1  - Nicht-HIV-Komorbiditäten und Bewegung bei deutschen Menschen, die mit HIV leben
N2  - The post-antiretroviral therapy era has transformed HIV into a chronic disease and non-HIV comorbidities (i.e., cardiovascular and mental diseases) are more prevalent in PLWH.  The source of these non-HIV comorbidities aside from traditional risk factor include HIV infection, inflammation, distorted immune activation, burden of chronic diseases, and unhealthy lifestyle like sedentarism. Exercise is known for its beneficial effects in mental and physical health; reasons why exercise is recommended to prevent and treat difference cardiovascular and mental diseases in the general population. This cumulative thesis aimed to comprehend the relation exercise has to non-HIV comorbidities in German PLWH. Four studies were conducted to 1) understand exercise effects in cardiorespiratory fitness and muscle strength on PLWH through a systematic review and meta-analyses and 2) determine the likelihood of German PLWH developing non-HIV comorbidities, in a cross-sectional study. Meta-analytic examination indicates PLWH cardiorespiratory fitness (VO2max SMD = 0.61 ml·kg·min-1, 95% CI: 0.35-0.88, z = 4.47, p < 0.001, I2 = 50%) and strength (of remark lowerbody strength by 16.8 kg, 95% CI: 13–20.6, p< 0.001) improves after an exercise intervention in comparison to a control group. Cross-sectional data suggest exercise has a positive effect on German PLWH mental health (less anxiety and depressive symptoms) and protects against the development of anxiety (PR: 0.57, 95%IC: 0.36 – 0.91, p = 0.01) and depression (PR: 0.62, 95%IC: 0.41 – 0.94, p = 0.01). Likewise, exercise duration is related to a lower likelihood of reporting heart arrhythmias (PR: 0.20, 95%IC: 0.10 – 0.60, p < 0.01) and exercise frequency to a lower likelihood of reporting diabetes mellitus (PR: 0.40, 95%IC: 0.10 – 1, p < 0.01) in German PLWH. A preliminary recommendation for German PLWH who want to engage in exercise can be to exercise ≥ 1 time per week, at an intensity of 5 METs per session or > 103 MET·min·day-1, with a duration ≥ 150 minutes per week. Nevertheless, further research is needed to comprehend exercise dose response and protective effect for cardiovascular diseases, anxiety, and depression in German PLWH.
N2  - In der Zeit seit der antiretroviralen Therapie hat sich HIV zu einer chronischen Erkrankung entwickelt und Nicht-HIV-Komorbiditäten, z.B. Herz-Kreislauf-Erkrankungen und psychische Erkrankungen, treten bei Menschen, die mit HIV leben, häufiger auf. Die Herkunft dieser Nicht-HIV-Komorbiditäten, neben den traditionellen Risikofaktoren, sind HIV-Infektion, chronische Entzündung, eine gestörte Immunaktivierung, chronische Erkrankungen und eine ungesunde Lebensweise wie Bewegungsmangel.
Bewegung ist bekannt für seine positive Wirkung auf die mentale und körperliche Gesundheit; das ist der Grund, warum Bewegung in der Prävention und der Behandlung verschiedener Herz-Kreislauf- und psychischer Erkrankungen in der Allgemeinbevölkerung empfohlen wird.
Ziel dieser kumulativen Arbeit war es, den Zusammenhang zwischen körperlicher Bewegung und nicht-HIV-Komorbiditäten bei deutschen Menschen, die mit HIV leben zu untersuchen. Vier Studien wurden durchgeführt, um 1) die Auswirkungen von Bewegung auf die kardiorespiratorische Fitness und die Muskelkraft von HIV-Infizierten durch eine systematische Übersichtsarbeit und Meta-Analysen zu verstehen und 2) zu bestimmen, ob HIV-positive Menschen, die Bewegung treiben, entwickeln einen Nicht-HIV-Komorbiditäten.
Die metaanalytische Untersuchung zeigt, dass sich die kardiorespiratorische Fitness (VO2max SMD = 0.61 mlkgmin-1, 95 % CI: 0.35-0.88, z = 4.47, p < 0.001, I2 = 50 %) und Kraft (Besonders in den unteren Extremitäten 16.8 kg, 95 % CI: 13–20.6, p< 0.001) nach einer Trainingsintervention im Vergleich zu einer Kontrollgruppe verbessert.
Querschnittdaten deuten darauf hin, dass Bewegung eine positive Wirkung auf die psychische Gesundheit den deutschen Menschen, die mit HIV leben hat (weniger Angst und depressive Symptome) und vor der Entwicklung von Angst (PR: 0,57, 95 % IC: 0,36 - 0,91, p = 0,01) und Depression (PR: 0,62, 95 % IC: 0,41 - 0,94, p = 0,01) schützt. Ebenso geht die Dauer der Bewegung mit einer geringeren Wahrscheinlichkeit für Herzrhythmusstörungen einher, (PR: 0,20, 95 % IC: 0,10 - 0,60, p < 0,01).
Eine vorläufige Empfehlung für deutsche Menschen, die mit HIV leben und die sich sportlich betätigen wollen, kann sein, ³ 1-mal pro Woche mit einer Intensität von 5 METs und einer Dauer von ³ 60 Minuten zu trainieren.
Dennoch sind weitere Forschungen erforderlich, um die Dosiswirkung und die schützende Wirkung von Bewegung auf Herz-Kreislauf-Erkrankungen, Angst und Depression bei deutschen Menschen, die mit HIV leben zu verstehen.
KW  - HIV
KW  - cardiovascular disease
KW  - anxiety
KW  - depression
KW  - exercise
KW  - Menschen, die mit HIV leben
KW  - Angst
KW  - Depression
KW  - kardiovaskuläre Erkrankungen
KW  - Bewegung
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-560842
ER  - 
TY  - GEN
A1  - Müller, Sandra
A1  - Dawczynski, Christine
A1  - Wiest, Johanna
A1  - Lorkowski, Stefan
A1  - Kipp, Anna Patricia
A1  - Schwerdtle, Tanja
T1  - Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Soils in Germany are commonly low in selenium; consequently, a sufficient dietary supply is not always ensured. The extent of such provision adequacy is estimated by the optimal effect range of biomarkers, which often reflects the physiological requirement. Preceding epidemiological studies indicate that low selenium serum concentrations could be related to cardiovascular diseases. Inter alia, risk factors for cardiovascular diseases are physical inactivity, overweight, as well as disadvantageous eating habits. In order to assess whether these risk factors can be modulated, a cardio-protective diet comprising fixed menu plans combined with physical exercise was applied in the German MoKaRi (modulation of cardiovascular risk factors) intervention study. We analyzed serum samples of the MoKaRi cohort (51 participants) for total selenium, GPx activity, and selenoprotein P at different timepoints of the study (0, 10, 20, 40 weeks) to explore the suitability of these selenium-associated markers as indicators of selenium status. Overall, the time-dependent fluctuations in serum selenium concentration suggest a successful change in nutritional and lifestyle behavior. Compared to baseline, a pronounced increase in GPx activity and selenoprotein P was observed, while serum selenium decreased in participants with initially adequate serum selenium content. SELENOP concentration showed a moderate positive monotonic correlation (r = 0.467, p < 0.0001) to total Se concentration, while only a weak linear relationship was observed for GPx activity versus total Se concentration (r = 0.186, p = 0.021). Evidently, other factors apart from the available Se pool must have an impact on the GPx activity, leading to the conclusion that, without having identified these factors, GPx activity should not be used as a status marker for Se
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 878 
KW  - Se
KW  - selenoprotein P
KW  - GPx activity
KW  - cardiovascular disease
KW  - status markers
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-460115
SN  - 1866-8372
IS  - 878
ER  - 
TY  - JOUR
A1  - Müller, Sandra
A1  - Dawczynski, Christine
A1  - Wiest, Johanna
A1  - Lorkowski, Stefan
A1  - Kipp, Anna Patricia
A1  - Schwerdtle, Tanja
T1  - Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study
JF  - Nutrients
N2  - Soils in Germany are commonly low in selenium; consequently, a sufficient dietary supply is not always ensured. The extent of such provision adequacy is estimated by the optimal effect range of biomarkers, which often reflects the physiological requirement. Preceding epidemiological studies indicate that low selenium serum concentrations could be related to cardiovascular diseases. Inter alia, risk factors for cardiovascular diseases are physical inactivity, overweight, as well as disadvantageous eating habits. In order to assess whether these risk factors can be modulated, a cardio-protective diet comprising fixed menu plans combined with physical exercise was applied in the German MoKaRi (modulation of cardiovascular risk factors) intervention study. We analyzed serum samples of the MoKaRi cohort (51 participants) for total selenium, GPx activity, and selenoprotein P at different timepoints of the study (0, 10, 20, 40 weeks) to explore the suitability of these selenium-associated markers as indicators of selenium status. Overall, the time-dependent fluctuations in serum selenium concentration suggest a successful change in nutritional and lifestyle behavior. Compared to baseline, a pronounced increase in GPx activity and selenoprotein P was observed, while serum selenium decreased in participants with initially adequate serum selenium content. SELENOP concentration showed a moderate positive monotonic correlation (r = 0.467, p < 0.0001) to total Se concentration, while only a weak linear relationship was observed for GPx activity versus total Se concentration (r = 0.186, p = 0.021). Evidently, other factors apart from the available Se pool must have an impact on the GPx activity, leading to the conclusion that, without having identified these factors, GPx activity should not be used as a status marker for Se
KW  - Se
KW  - selenoprotein P
KW  - GPx activity
KW  - cardiovascular disease
KW  - status markers
Y1  - 2020
U6  - https://doi.org/10.3390/nu12030676
SN  - 2072-6643
VL  - 12
IS  - 3
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Chen, You-Peng
A1  - Lu, Yong-Ping
A1  - Li, Jian
A1  - Liu, Zhi-Wei
A1  - Chen, Wen-Jing
A1  - Liang, Xu-Jing
A1  - Chen, Xin
A1  - Wen, Wang-Rong
A1  - Xiao, Xiao-Min
A1  - Reichetzeder, Christoph
A1  - Hocher, Berthold
T1  - Fetal and maternal angiotensin (1-7) are associated with preterm birth
JF  - Journal of hypertension
N2  - Background: Recent studies show that preterm birth is associated with hypertension in later life. The renin-angiotensin system (RAS) during pregnancy influences fetal growth and development. In the current study, we investigated the impact of fetal as well as maternal angiotensin (1-7) [Ang (1-7)] and angiotensin II (Ang II) plasma concentrations on the risk of preterm birth.
 Methods: Three hundred and nine pregnant women were prospectively included into the study. The pregnant women were divided into two groups, for example, preterm birth of lower than 37 gestational weeks (n = 17) and full-term birth of 37 gestational weeks or more (n = 292). Maternal and neonatal plasma Ang (1-7) and Ang II concentrations were analyzed at birth from maternal venous blood and umbilical cord blood, respectively. Risk factors for premature birth were determined by multiple logistic regression analysis.
 Results: Fetal and maternal plasma Ang (1-7) concentrations in the preterm group were lower than those of the term group fetal Ang (1-7) preterm birth: 486.15 +/- 337.34 ng/l and fetal Ang (1-7) term birth: 833.84 +/- 698.12 ng/l and maternal Ang (1-7) preterm birth: 399.86 +/- 218.93 ng/l; maternal Ang (1-7) term birth: 710.34 +/- 598.22 ng/l. Multiple logistic regression analysis considering confounding factors revealed that preeclampsia (P < 0.001), premature rupture of membranes (P = 0.001), lower concentration of maternal Ang (1-7) (P = 0.013) and fetal plasma Ang (1-7) (P = 0.032) were independently associated with preterm birth. We could furthermore demonstrate that the maternal Ang (1-7)/Ang II ratio is independently associated with gestational hypertension or preeclampsia, factors causing preterm birth.
 Conclusions: Lower concentrations of maternal and fetal Ang (1-7) are independently associated with preterm birth - a risk factor of hypertension in later life.
KW  - angiotensin (1-7)
KW  - angiotensin II
KW  - cardiovascular disease
KW  - fetal programming
KW  - intrauterine fetal growth
KW  - pregnancy
KW  - preterm delivery
Y1  - 2014
U6  - https://doi.org/10.1097/HJH.0000000000000251
SN  - 0263-6352
SN  - 1473-5598
VL  - 32
IS  - 9
SP  - 1833
EP  - 1841
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Behrendt, Tom
A1  - Bielitzki, Robert
A1  - Behrens, Martin
A1  - Herold, Fabian
A1  - Schega, Lutz
T1  - Effects of intermittent hypoxia-hyperoxia on performance- and health-related outcomes in humans
BT  - a systematic review
JF  - Sports medicine - open
N2  - Background: 
Intermittent hypoxia applied at rest or in combination with exercise promotes multiple beneficial adaptations with regard to performance and health in humans. It was hypothesized that replacing normoxia by moderate hyperoxia can increase the adaptive response to the intermittent hypoxic stimulus.

Objective:
Our objective was to systematically review the current state of the literature on the effects of chronic intermittent hypoxia-hyperoxia (IHH) on performance- and health-related outcomes in humans.

Methods:
PubMed, Web of Science (TM), Scopus, and Cochrane Library databases were searched in accordance with PRISMA guidelines (January 2000 to September 2021) using the following inclusion criteria: (1) original research articles involving humans, (2) investigation of the chronic effect of IHH, (3) inclusion of a control group being not exposed to IHH, and (4) articles published in peer-reviewed journals written in English. 

Results:
 Of 1085 articles initially found, eight studies were included. IHH was solely performed at rest in different populations including geriatric patients (n = 1), older patients with cardiovascular (n = 3) and metabolic disease (n = 2) or cognitive impairment (n = 1), and young athletes with overtraining syndrome (n = 1). The included studies confirmed the beneficial effects of chronic exposure to IHH, showing improvements in exercise tolerance, peak oxygen uptake, and global cognitive functions, as well as lowered blood glucose levels. A trend was discernible that chronic exposure to IHH can trigger a reduction in systolic and diastolic blood pressure. The evidence of whether IHH exerts beneficial effects on blood lipid levels and haematological parameters is currently inconclusive. A meta-analysis was not possible because the reviewed studies had a considerable heterogeneity concerning the investigated populations and outcome parameters. 

Conclusion: 
Based on the published literature, it can be suggested that chronic exposure to IHH might be a promising non-pharmacological intervention strategy for improving peak oxygen consumption, exercise tolerance, and cognitive performance as well as reducing blood glucose levels, and systolic and diastolic blood pressure in older patients with cardiovascular and metabolic diseases or cognitive impairment. However, further randomized controlled trials with adequate sample sizes are needed to confirm and extend the evidence. This systematic review was registered on the international prospective register of systematic reviews (PROSPERO-ID: CRD42021281248) (https://www.crd.york.ac.uk/prospero/).
KW  - hypoxic conditioning
KW  - cognitive impairment
KW  - metabolic disease
KW  - cardiovascular disease
KW  - geriatrics
KW  - therapy
Y1  - 2022
U6  - https://doi.org/10.1186/s40798-022-00450-x
SN  - 2199-1170
SN  - 2198-9761
VL  - 8
IS  - 1
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Chaykovska, Lyubov
A1  - Zientara, Alicja
A1  - Reser, Diana
A1  - Weise, Alexander
A1  - Reichert, Wolfgang
A1  - Hocher, Berthold
T1  - Development and validation of a macroarray system - MutaCHIP (R) ARTERO - for the detection of genetic variants involved in the pathogenesis of atherosclerosis
JF  - Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion
N2  - Background: Cardiovascular diseases are the leading cause of death in developed countries. The underlying mechanism is often atherosclerotic remodeling of blood vessels in organs such as heart, kidney, brain, and large arteries in case of peripheral arterial disease. Beside environmental and behavioral factors such as smoking or lack of physical activity, genetic variants in genes involved in lipid metabolism, blood pressure regulation, oxidative stress, and coagulation play a prominent role in the pathogenesis of atherosclerosis.
 Methods: Thus, we developed and validated for clinical use and research a macroarray system for the simultaneous detection of key genetic variants in genes involved in lipid metabolism, blood pressure regulation, oxidative stress, and coagulation.
 Results: When compared with standard PCR technologies to determine all these genetic variants in parallel, the macroarray system (MutaCHIP (R) ARTERO) was as accurate but faster, cheaper, and easier to handle compared to classical real time PCR based technologies.
 Conclusions: MutaCHIP (R) ARTERO is a gene chip for diagnostics of a complex genetic panel involved in the pathogenesis of atherosclerosis. This method is as sensitive and precise as real time PCR and is able to replicate real time PCR data previously validated in evaluation studies.
KW  - cardiovascular disease
KW  - atherosclerosis
KW  - genes
KW  - rapid detection method
KW  - macroarray
Y1  - 2014
U6  - https://doi.org/10.7754/Clin.Lab.2014.140104
SN  - 1433-6510
VL  - 60
IS  - 5
SP  - 873
EP  - 878
PB  - Clin Lab Publ., Verl. Klinisches Labor
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Braune, Steffen
A1  - Gross, M.
A1  - Walter, M.
A1  - Zhou, Shengqiang
A1  - Dietze, Siegfried
A1  - Rutschow, S.
A1  - Lendlein, Andreas
A1  - Tschoepe, C.
A1  - Jung, Friedrich
T1  - Adhesion and activation of platelets from subjects with coronary artery disease and apparently healthy individuals on biomaterials
JF  - Journal of biomedical materials research : an official journal of the Society for Biomaterials, the Japanese Society for Biomaterials; the Australian Society for Biomaterials
N2  - On the basis of the clinical studies in patients with coronary artery disease (CAD) presenting an increased percentage of activated platelets, we hypothesized that hemocompatibility testing utilizing platelets from healthy individuals may result in an underestimation of the materials' thrombogenicity. Therefore, we investigated the interaction of polymer-based biomaterials with platelets from CAD patients in comparison to platelets from apparently healthy individuals. In vitro static thrombogenicity tests revealed that adherent platelet densities and total platelet covered areas were significantly increased for the low (polydimethylsiloxane, PDMS) and medium (Collagen) thrombogenic surfaces in the CAD group compared to the healthy subjects group. The area per single platelet—indicating the spreading and activation of the platelets—was markedly increased on PDMS treated with PRP from CAD subjects. This could not be observed for collagen or polytetrafluoroethylene (PTFE). For the latter material, platelet adhesion and surface coverage did not differ between the two groups. Irrespective of the substrate, the variability of these parameters was increased for CAD patients compared to healthy subjects. This indicates a higher reactivity of platelets from CAD patients compared to the healthy individuals. Our results revealed, for the first time, that utilizing platelets from apparently healthy donors bears the risk of underestimating the thrombogenicity of polymer-based biomaterials.
KW  - platelets
KW  - biomaterials
KW  - hemocompatibility
KW  - cardiovascular disease
KW  - cardiovascular implant
Y1  - 2016
U6  - https://doi.org/10.1002/jbm.b.33366
SN  - 1552-4973
SN  - 1552-4981
VL  - 104
SP  - 210
EP  - 217
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Jannasch, Franziska
A1  - Nickel, Daniela V.
A1  - Bergmann, Manuela M.
A1  - Schulze, Matthias Bernd
T1  - A new evidence-based diet score to capture associations of food consumption and chronic disease risk
JF  - Nutrients / Molecular Diversity Preservation International (MDPI)
N2  - Previously, the attempt to compile German dietary guidelines into a diet score was predominantly not successful with regards to preventing chronic diseases in the EPIC-Potsdam study. Current guidelines were supplemented by the latest evidence from systematic reviews and expert papers published between 2010 and 2020 on the prevention potential of food groups on chronic diseases such as type 2 diabetes, cardiovascular diseases and cancer. A diet score was developed by scoring the food groups according to a recommended low, moderate or high intake. The relative validity and reliability of the diet score, assessed by a food frequency questionnaire, was investigated. The consideration of current evidence resulted in 10 key food groups being preventive of the chronic diseases of interest. They served as components in the diet score and were scored from 0 to 1 point, depending on their recommended intake, resulting in a maximum of 10 points. Both the reliability (r = 0.53) and relative validity (r = 0.43) were deemed sufficient to consider the diet score as a stable construct in future investigations. This new diet score can be a promising tool to investigate dietary intake in etiological research by concentrating on 10 key dietary determinants with evidence-based prevention potential for chronic diseases.
KW  - diet score
KW  - dietary guidelines
KW  - food groups
KW  - chronic disease
KW  - type 2
KW  - diabetes
KW  - cardiovascular disease
KW  - cancer
KW  - prevention
KW  - reliability;
KW  - validity
Y1  - 2022
U6  - https://doi.org/10.3390/nu14112359
SN  - 2072-6643
VL  - 14
IS  - 11
PB  - MDPI
CY  - Basel
ER  -